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    Mov10 Mov10 RISC complex RNA helicase [ Mus musculus (house mouse) ]

    Gene ID: 17454, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Mov10provided by MGI
    Official Full Name
    Mov10 RISC complex RNA helicaseprovided by MGI
    Primary source
    MGI:MGI:97054
    See related
    Ensembl:ENSMUSG00000002227 AllianceGenome:MGI:97054
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mov-10
    Summary
    Predicted to enable 5'-3' RNA helicase activity and RNA binding activity. Involved in negative regulation of transposition, RNA-mediated and regulation of neuron projection arborization. Located in cytosol and nucleus. Is expressed in brain; gut; sensory organ; testis; and turbinate bone primordium. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human MOV10 (Mov10 RISC complex RNA helicase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 17.0), small intestine adult (RPKM 14.9) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mov10 in Genome Data Viewer
    Location:
    3 F2.2; 3 45.87 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (104702144..104725935, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (104794828..104818619, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08620 Neighboring gene protein phosphatase 1J Neighboring gene ras homolog family member C Neighboring gene STARR-seq mESC enhancer starr_08622 Neighboring gene capping actin protein of muscle Z-line subunit alpha 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:104667925-104668034 Neighboring gene suppression of tumorigenicity 7-like Neighboring gene ribosomal protein S27 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Host MOV10 is induced to restrict herpes simplex virus 1 lytic infection by promoting type I interferon response. Yang X, et al. PLoS Pathog, 2022 Feb. PMID 35157734, Free PMC Article
    2. Unwinding the roles of RNA helicase MOV10. Nawaz A, et al. Wiley Interdiscip Rev RNA, 2022 Mar. PMID 34327836, Free PMC Article
    3. Interaction of several related GC-box- and GT-box-binding proteins with the intronic enhancer is required for differential expression of the gb110 gene in embryonal carcinoma cells. Hamann L, et al. Mol Cell Biol, 1994 Sep. PMID 8065313, Free PMC Article
    4. Endogenous Moloney leukemia virus in nonviremic Mov substrains of mice carries defects in the proviral genome. Schnieke A, et al. J Virol, 1983 Feb. PMID 6834466, Free PMC Article
    5. Infectivity and structure of molecular clones obtained from two genetically transmitted Moloney leukemia proviral genomes. Harbers K, et al. Nucleic Acids Res, 1982 Apr 24. PMID 6281733, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The MOV10 RNA helicase is a dosage-dependent host restriction factor for LINE1 retrotransposition in mice.
      Title: The MOV10 RNA helicase is a dosage-dependent host restriction factor for LINE1 retrotransposition in mice.
    2. Unwinding the roles of RNA helicase MOV10.
      Title: Unwinding the roles of RNA helicase MOV10.
    3. Host MOV10 is induced to restrict herpes simplex virus 1 lytic infection by promoting type I interferon response.
      Title: Host MOV10 is induced to restrict herpes simplex virus 1 lytic infection by promoting type I interferon response.
    4. FMRP and MOV10 regulate Dicer1 expression and dendrite development.
      Title: FMRP and MOV10 regulate Dicer1 expression and dendrite development.
    5. Mov10 is essential for normal neuronal development and brain function. Mov10 preferentially binds RNAs involved in actin binding, neuronal projection, and cytoskeleton. This is a completely new and critically important function for Mov10 in neuronal development.
      Title: Mov10 suppresses retroelements and regulates neuronal development and function in the developing brain.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2)  1 citation
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 5'-3' RNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 3'-UTR-mediated mRNA destabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in miRNA-mediated gene silencing by mRNA destabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in miRNA-mediated post-transcriptional gene silencing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neuron projection arborization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulatory ncRNA-mediated gene silencing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrotransposon silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in retrotransposon silencing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrotransposon silencing by mRNA destabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in P granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in P-body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putative helicase MOV-10
    Names
    moloney leukemia virus 10 protein
    NP_001156912.2
    NP_001156913.1
    NP_001397354.1
    NP_001397355.1
    NP_001397356.1
    NP_001397357.1
    NP_032645.2
    XP_006501163.1
    XP_006501164.1
    XP_030108315.1
    XP_036018811.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163440.2 → NP_001156912.2  putative helicase MOV-10 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC171110
      Consensus CDS
      CCDS51033.1
      UniProtKB/Swiss-Prot
      P23249, Q9DC64
      Related
      ENSMUSP00000126897.2, ENSMUST00000166979.8

    2. NM_001163441.2 → NP_001156913.1  putative helicase MOV-10 isoform b

      See identical proteins and their annotated locations for NP_001156913.1

      Status: VALIDATED

      Source sequence(s)
      AC171110
      Consensus CDS
      CCDS38579.1
      UniProtKB/Swiss-Prot
      P23249, Q9DC64
      UniProtKB/TrEMBL
      D3Z3E8, Q3TFC0, Q3UD86
      Related
      ENSMUSP00000128246.2, ENSMUST00000168015.8
      Conserved Domains (2) summary
      cd18808
      Location:735 → 940
      SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
      cd18038
      Location:499 → 734
      DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase

    3. NM_001410425.1 → NP_001397354.1  putative helicase MOV-10 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC171110

    4. NM_001410426.1 → NP_001397355.1  putative helicase MOV-10 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC171110

    5. NM_001410427.1 → NP_001397356.1  putative helicase MOV-10 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC171110

    6. NM_001410428.1 → NP_001397357.1  putative helicase MOV-10 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC171110

    7. NM_008619.3 → NP_032645.2  putative helicase MOV-10 isoform b

      See identical proteins and their annotated locations for NP_032645.2

      Status: VALIDATED

      Source sequence(s)
      AC171110
      Consensus CDS
      CCDS38579.1
      UniProtKB/Swiss-Prot
      P23249, Q9DC64
      UniProtKB/TrEMBL
      D3Z3E8, Q3TFC0, Q3UD86
      Related
      ENSMUSP00000002297.6, ENSMUST00000002297.12
      Conserved Domains (2) summary
      cd18808
      Location:735 → 940
      SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
      cd18038
      Location:499 → 734
      DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      104702144..104725935 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252455.1 → XP_030108315.1  putative helicase MOV-10 isoform X2

      UniProtKB/TrEMBL
      D3Z3E8, Q3TFC0, Q3UD86
      Conserved Domains (2) summary
      cd18808
      Location:679 → 884
      SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
      cd18038
      Location:443 → 678
      DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase

    2. XM_036162918.1 → XP_036018811.1  putative helicase MOV-10 isoform X2

      UniProtKB/TrEMBL
      D3Z3E8, Q3TFC0, Q3UD86
      Conserved Domains (2) summary
      cd18808
      Location:679 → 884
      SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
      cd18038
      Location:443 → 678
      DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase

    3. XM_006501100.1 → XP_006501163.1  putative helicase MOV-10 isoform X1

      See identical proteins and their annotated locations for XP_006501163.1

      UniProtKB/Swiss-Prot
      P23249, Q9DC64
      UniProtKB/TrEMBL
      D3Z3E8, Q3TFC0, Q3UD86
      Conserved Domains (2) summary
      cd18808
      Location:735 → 940
      SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
      cd18038
      Location:499 → 734
      DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase

    4. XM_006501101.4 → XP_006501164.1  putative helicase MOV-10 isoform X1

      See identical proteins and their annotated locations for XP_006501164.1

      UniProtKB/Swiss-Prot
      P23249, Q9DC64
      UniProtKB/TrEMBL
      D3Z3E8, Q3TFC0, Q3UD86
      Conserved Domains (2) summary
      cd18808
      Location:735 → 940
      SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
      cd18038
      Location:499 → 734
      DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase

    RNA

    1. XR_375493.4 RNA Sequence

      Related
      ENSMUST00000106774.8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P23249.2 GenPept UniProtKB/Swiss-Prot:P23249

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