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    Mitf melanogenesis associated transcription factor [ Mus musculus (house mouse) ]

    Gene ID: 17342, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Mitfprovided by MGI
    Official Full Name
    melanogenesis associated transcription factorprovided by MGI
    Primary source
    MGI:MGI:104554
    See related
    Ensembl:ENSMUSG00000035158 AllianceGenome:MGI:104554
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Wh; bw; mi; vit; BCC2; Bhlhe32; Gsfbcc2; Vitiligo
    Summary
    This transcription factor serves at a critical point between extracellular signaling and downstream targets in cell specification in early eye and neural crest development. Mutant alleles have been identified that generate distinct phenotypes. Some of these alleles are being used to model the human diseases Waardenburg syndrome IIa and Tietz syndrome. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in placenta adult (RPKM 9.0), heart adult (RPKM 4.3) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 D3; 6 45.05 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (97783966..97998321)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (97807002..98021360)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr6:97690206-97690507 Neighboring gene predicted gene, 24565 Neighboring gene predicted gene, 23703 Neighboring gene ribosomal protein S27 pseudogene Neighboring gene STARR-seq mESC enhancer starr_16804 Neighboring gene STARR-seq mESC enhancer starr_16808 Neighboring gene predicted gene, 53321 Neighboring gene predicted gene, 53320 Neighboring gene STARR-seq mESC enhancer starr_16809 Neighboring gene VISTA enhancer mm60 Neighboring gene predicted gene, 32592 Neighboring gene MyoD family inhibitor domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse microphthalmia-associated transcription factor (Mitf) mutations affect the structure of the retinal vasculature. Daníelsson SB, et al. Acta Ophthalmol, 2022 Dec. PMID 35348289, Free PMC Article
    2. Mitf is required for T cell maturation by regulating dendritic cell homing to the thymus. Karigane D, et al. Biochem Biophys Res Commun, 2022 Mar 12. PMID 35108651
    3. Mitf Links Neuronal Activity and Long-Term Homeostatic Intrinsic Plasticity. Atacho DAM, et al. eNeuro, 2020 Mar/Apr. PMID 32193365, Free PMC Article
    4. Mechanism of conditional partner selectivity in MITF/TFE family transcription factors with a conserved coiled coil stammer motif. Pogenberg V, et al. Nucleic Acids Res, 2020 Jan 24. PMID 31777941, Free PMC Article
    5. The microphthalmia-associated transcription factor (Mitf) gene and its role in regulating eye function. García-Llorca A, et al. Sci Rep, 2019 Oct 28. PMID 31659211, Free PMC Article

    See all (519) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mitf regulates gene expression networks implicated in B cell homeostasis, germinal center responses, and tolerance.
      Title: Mitf regulates gene expression networks implicated in B cell homeostasis, germinal center responses, and tolerance.
    2. Melanogrit potentiates melanogenesis by escalating cellular tyrosinase activity and MITF levels via pERK inhibition.
      Title: Melanogrit potentiates melanogenesis by escalating cellular tyrosinase activity and MITF levels via pERK inhibition.
    3. Ataxia Telangiectasia Mutated Signaling Delays Skin Pigmentation upon UV Exposure by Mediating MITF Function toward DNA Repair Mode.
      Title: Ataxia Telangiectasia Mutated Signaling Delays Skin Pigmentation upon UV Exposure by Mediating MITF Function toward DNA Repair Mode.
    4. Progressive Cone-Rod Dystrophy and RPE Dysfunction in Mitf[mi/+] Mice.
      Title: Progressive Cone-Rod Dystrophy and RPE Dysfunction in Mitf(mi/+) Mice.
    5. DAPL1 deficiency in mice impairs antioxidant defenses in the RPE and leads to retinal degeneration with AMD-like features.
      Title: DAPL1 deficiency in mice impairs antioxidant defenses in the RPE and leads to retinal degeneration with AMD-like features.
    6. Novel role of microphthalmia-associated transcription factor in modulating the differentiation and immunosuppressive functions of myeloid-derived suppressor cells.
      Title: Novel role of microphthalmia-associated transcription factor in modulating the differentiation and immunosuppressive functions of myeloid-derived suppressor cells.
    7. Mouse microphthalmia-associated transcription factor (Mitf) mutations affect the structure of the retinal vasculature.
      Title: Mouse microphthalmia-associated transcription factor (Mitf) mutations affect the structure of the retinal vasculature.
    8. MicroRNA-183-5p regulates MITF expression in vitiligo skin depigmentation.
      Title: MicroRNA-183-5p regulates MITF expression in vitiligo skin depigmentation.
    9. Mitf is required for T cell maturation by regulating dendritic cell homing to the thymus.
      Title: Mitf is required for T cell maturation by regulating dendritic cell homing to the thymus.
    10. Circadian clock protein BMAL1 regulates melanogenesis through MITF in melanoma cells.
      Title: Circadian clock protein BMAL1 regulates melanogenesis through MITF in melanoma cells.
    Submit: New GeneRIF Correction See all GeneRIFs (158)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124309, MGC124310

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables E-box binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables E-box binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein dimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within bone remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within camera-type eye development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of melanocyte apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in melanocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within melanocyte differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within melanocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within osteoclast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pigmentation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within pigmentation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of RNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of osteoclast differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of osteoclast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    microphthalmia-associated transcription factor
    Names
    black eyed white
    microphtalmia-associated transcription factor

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113198.2 → NP_001106669.1  microphthalmia-associated transcription factor isoform 1

      See identical proteins and their annotated locations for NP_001106669.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1, also known as Mitf-A).
      Source sequence(s)
      AC131676, AC157098, AC158650
      Consensus CDS
      CCDS51861.1
      UniProtKB/Swiss-Prot
      A0A0N4SVJ5, O08885, O88203, Q08843, Q08874, Q3U2D2, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9
      UniProtKB/TrEMBL
      E9PZ28
      Related
      ENSMUSP00000044938.8, ENSMUST00000043637.14
      Conserved Domains (3) summary
      cd18926
      Location:300 → 403
      bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
      pfam11851
      Location:397 → 522
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:56 → 194
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    2. NM_001178049.2 → NP_001171520.1  microphthalmia-associated transcription factor isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3, also known as Mitf-H) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC157098, AC158650
      Consensus CDS
      CCDS51862.1
      UniProtKB/TrEMBL
      E9PZ28
      Related
      ENSMUSP00000098683.4, ENSMUST00000101123.10
      Conserved Domains (3) summary
      cd00083
      Location:293 → 353
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam11851
      Location:381 → 506
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:40 → 178
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    3. NM_001410051.1 → NP_001396980.1  microphthalmia-associated transcription factor isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC131676, AC157098, AC158650

    4. NM_001410052.1 → NP_001396981.1  microphthalmia-associated transcription factor isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC131676, AC157098, AC158650
      UniProtKB/TrEMBL
      A0A5H1ZRM6
      Related
      ENSMUSP00000145132.2, ENSMUST00000203884.3

    5. NM_001410053.1 → NP_001396982.1  microphthalmia-associated transcription factor isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC157098, AC158650

    6. NM_001410054.1 → NP_001396983.1  microphthalmia-associated transcription factor isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC131676, AC157098, AC158650

    7. NM_001410055.1 → NP_001396984.1  microphthalmia-associated transcription factor isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC131676, AC157098, AC158650

    8. NM_001410056.1 → NP_001396985.1  microphthalmia-associated transcription factor isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC131676, AC157098, AC158650

    9. NM_001410057.1 → NP_001396986.1  microphthalmia-associated transcription factor isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC131676, AC157098, AC158650

    10. NM_001410058.1 → NP_001396987.1  microphthalmia-associated transcription factor isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC131676, AC158650

    11. NM_001410059.1 → NP_001396988.1  microphthalmia-associated transcription factor isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC158650
      UniProtKB/TrEMBL
      I6L9I6

    12. NM_008601.4 → NP_032627.1  microphthalmia-associated transcription factor isoform 2

      See identical proteins and their annotated locations for NP_032627.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2, also known as Mitf-M) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC158650
      Consensus CDS
      CCDS20385.1
      UniProtKB/TrEMBL
      A0A0N4SV79, Q32MU7
      Related
      ENSMUSP00000044459.7, ENSMUST00000043628.13
      Conserved Domains (3) summary
      cd00083
      Location:202 → 262
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam11851
      Location:290 → 415
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:11 → 87
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      97783966..97998321
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165905.1 → XP_036021798.1  microphthalmia-associated transcription factor isoform X11

      Conserved Domains (3) summary
      cd18926
      Location:164 → 267
      bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
      pfam11851
      Location:261 → 386
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:56 → 118
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    2. XM_030255210.2 → XP_030111070.1  microphthalmia-associated transcription factor isoform X3

      UniProtKB/TrEMBL
      E9PZ28
      Conserved Domains (3) summary
      pfam11851
      Location:390 → 515
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:55 → 193
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
      cd18926
      Location:293 → 396
      bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins

    3. XM_030255214.2 → XP_030111074.1  microphthalmia-associated transcription factor isoform X9

      UniProtKB/TrEMBL
      E9PZ28
      Conserved Domains (3) summary
      pfam11851
      Location:339 → 464
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:4 → 142
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
      cd18926
      Location:242 → 345
      bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins

    4. XM_030255213.2 → XP_030111073.1  microphthalmia-associated transcription factor isoform X8

      UniProtKB/TrEMBL
      E9PZ28
      Conserved Domains (3) summary
      cd18926
      Location:248 → 351
      bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
      pfam11851
      Location:345 → 470
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:4 → 142
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    5. XM_006505692.5 → XP_006505755.1  microphthalmia-associated transcription factor isoform X8

      See identical proteins and their annotated locations for XP_006505755.1

      UniProtKB/TrEMBL
      E9PZ28
      Conserved Domains (3) summary
      cd18926
      Location:248 → 351
      bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
      pfam11851
      Location:345 → 470
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:4 → 142
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    6. XM_006505691.5 → XP_006505754.1  microphthalmia-associated transcription factor isoform X6

      UniProtKB/TrEMBL
      E9PZ28
      Conserved Domains (3) summary
      pfam11851
      Location:369 → 494
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:28 → 166
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
      cd18926
      Location:272 → 375
      bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins

    7. XM_017321428.3 → XP_017176917.1  microphthalmia-associated transcription factor isoform X7

      UniProtKB/TrEMBL
      E9PZ28
      Conserved Domains (3) summary
      pfam11851
      Location:368 → 493
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:27 → 165
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
      cd18926
      Location:271 → 374
      bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins

    8. XM_006505689.5 → XP_006505752.1  microphthalmia-associated transcription factor isoform X4

      UniProtKB/TrEMBL
      E9PZ28
      Conserved Domains (3) summary
      pfam11851
      Location:380 → 505
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:39 → 177
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
      cd18926
      Location:283 → 386
      bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins

    9. XM_006505694.1 → XP_006505757.1  microphthalmia-associated transcription factor isoform X8

      See identical proteins and their annotated locations for XP_006505757.1

      UniProtKB/TrEMBL
      E9PZ28
      Related
      ENSMUSP00000108965.2, ENSMUST00000113339.8
      Conserved Domains (3) summary
      cd18926
      Location:248 → 351
      bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
      pfam11851
      Location:345 → 470
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:4 → 142
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    10. XM_036165907.1 → XP_036021800.1  microphthalmia-associated transcription factor isoform X12

      UniProtKB/TrEMBL
      A0A0N4SV79
      Conserved Domains (3) summary
      cd18926
      Location:132 → 235
      bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
      pfam11851
      Location:229 → 354
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:1 → 26
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    11. XM_036165906.1 → XP_036021799.1  microphthalmia-associated transcription factor isoform X12

      UniProtKB/TrEMBL
      A0A0N4SV79
      Conserved Domains (3) summary
      cd18926
      Location:132 → 235
      bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
      pfam11851
      Location:229 → 354
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:1 → 26
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    12. XM_006505695.5 → XP_006505758.1  microphthalmia-associated transcription factor isoform X10

      UniProtKB/TrEMBL
      A0A0N4SV79
      Related
      ENSMUSP00000144988.2, ENSMUST00000203938.2
      Conserved Domains (3) summary
      pfam11851
      Location:284 → 409
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:11 → 87
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
      cd18926
      Location:187 → 290
      bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08874.4 GenPept UniProtKB/Swiss-Prot:Q08874

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