Meox2 mesenchyme homeobox 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Meox2provided by MGI
Official Full Name: mesenchyme homeobox 2provided by MGI
Primary source: MGI:MGI:103219
See related: Ensembl:ENSMUSG00000036144 AllianceGenome:MGI:103219
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gax; Mox2; Mox-2
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including angiogenesis; skeletal muscle tissue development; and somite specification. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; heart; and musculoskeletal system. Orthologous to human MEOX2 (mesenchyme homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in limb E14.5 (RPKM 32.3), mammary gland adult (RPKM 9.3) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 A3; 12 16.84 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (37158539..37229533)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (37108540..37179534)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transcription factor mesenchyme homeobox protein 2 (MEOX2) modulates nociceptor function.
Title: Transcription factor mesenchyme homeobox protein 2 (MEOX2) modulates nociceptor function.
Facilitation of Bone Healing Processes Based on the Developmental Function of Meox2 in Tooth Loss Lesion.
Title: Facilitation of Bone Healing Processes Based on the Developmental Function of Meox2 in Tooth Loss Lesion.
Chemerin-CMKLR1 activates Akt/mTOR and ERK pathways and facilitates preadipocyte proliferation, adipogenesis, and angiogenesis. Gax weakens the effect of chemerin on preadipocyte biofunctions.
Title: Gax suppresses chemerin/CMKLR1-induced preadipocyte biofunctions through the inhibition of Akt/mTOR and ERK signaling pathways.
Meox2 haploinsufficiency increases neuronal cell loss in Alzheimer's disease.
Title: Meox2 haploinsufficiency increases neuronal cell loss in a mouse model of Alzheimer's disease.
Microarray profiling on freshly isolated ECs had a genetic signature for microvascular heart ECs and identified Meox2/Tcf15 heterodimers as novel transcriptional determinants. This signature was similar in skeletal muscle and adipose tissue endothelium.
Title: Meox2/Tcf15 heterodimers program the heart capillary endothelium for cardiac fatty acid uptake.
The miRNA family miR-130/301/721 enhances induced pluripotent stem cells generation via repression of Meox2.
Title: miRNA screening reveals a new miRNA family stimulating iPS cell generation via regulation of Meox2.
ectopic Meox2 suppressed epithelial cell proliferation in cooperation with TGF-beta1, and mediated induction of the cell cycle inhibitor gene p21.
Title: Functional role of Meox2 during the epithelial cytostatic response to TGF-beta.
Meox2 binding to RNF10 protein, human, was characterized.
Title: Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10.
reduction of Meox-2 function is associated with susceptibility to cleft palate
Title: Analysis of Meox-2 mutant mice reveals a novel postfusion-based cleft palate.
Results demonstrate that Meox1 and Meox2 genes function together and upstream of several genetic hierarchies that are required for the development of somites.
Title: The concerted action of Meox homeobox genes is required upstream of genetic pathways essential for the formation, patterning and differentiation of somites.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1)
Targeted (3) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI528662 (e-PCR)
- UniSTS:180387

Z16406 (e-PCR)
- UniSTS:163523

Z16406 (e-PCR)
- UniSTS:125916

MEOX2 (e-PCR)
- UniSTS:23282

Meox2 (e-PCR), detects polymorphism
- UniSTS:143865

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fibroblast proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within limb development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell migration involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within roof of mouth development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in somite development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within somite specification	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: homeobox protein MOX-2

Names: growth arrest-specific homeobox

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.