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    Rdh11 retinol dehydrogenase 11 [ Mus musculus (house mouse) ]

    Gene ID: 17252, updated on 21-Apr-2024

    Summary

    Official Symbol
    Rdh11provided by MGI
    Official Full Name
    retinol dehydrogenase 11provided by MGI
    Primary source
    MGI:MGI:102581
    See related
    Ensembl:ENSMUSG00000066441 AllianceGenome:MGI:102581
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mdt1; Psdr1; SCALD; ralR1; Arsdr1; CGI-82; HCBP12; M42C60; Ube-1c; UBE-1c1; 2610319N22Rik
    Summary
    Enables aldehyde dehydrogenase (NADP+) activity. Involved in cellular detoxification of aldehyde; retinol metabolic process; and visual perception. Acts upstream of or within adaptation of rhodopsin mediated signaling. Located in photoreceptor inner segment. Is expressed in cerebral cortex ventricular layer and diencephalon. Orthologous to human RDH11 (retinol dehydrogenase 11). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 59.5), liver E18 (RPKM 35.6) and 22 other tissues See more
    Orthologs
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    Genomic context

    Location:
    12 C3; 12 35.51 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (79221007..79238629, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (79174233..79191855, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene arginase type II Neighboring gene predicted gene, 40462 Neighboring gene vesicle transport through interaction with t-SNAREs 1B Neighboring gene STARR-positive B cell enhancer ABC_E10761 Neighboring gene STARR-positive B cell enhancer ABC_E11514 Neighboring gene retinol dehydrogenase 12 Neighboring gene zinc finger, FYVE domain containing 26 Neighboring gene STARR-seq mESC enhancer starr_32594 Neighboring gene STARR-positive B cell enhancer ABC_E920

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aldehyde dehydrogenase (NADP+) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables all-trans-retinol dehydrogenase (NADP+) activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cellular detoxification of aldehyde IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular detoxification of aldehyde ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within retinal metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in retinoid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retinol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in visual perception IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in photoreceptor inner segment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT located_in photoreceptor outer segment membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    retinol dehydrogenase 11
    Names
    all-trans and 9-cis
    androgen-regulated short-chain dehydrogenase/reductase 1
    cell line MC/9.IL4 derived transcript 1
    cell line MC/9.IL4-derived protein 1
    prostate short-chain dehydrogenase/reductase 1
    retinal reductase 1
    short-chain aldehyde dehydrogenase
    NP_001349198.1
    NP_001349199.1
    NP_067532.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362269.1NP_001349198.1  retinol dehydrogenase 11 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154585
      Consensus CDS
      CCDS88359.1
      UniProtKB/TrEMBL
      Q9R1R8, Q9R1R9
      Related
      ENSMUSP00000082352.7, ENSMUST00000085254.7
      Conserved Domains (1) summary
      cl25409
      Location:22290
      SDR; Short-chain dehydrogenases/reductases (SDR)
    2. NM_001362270.1NP_001349199.1  retinol dehydrogenase 11 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154585
      UniProtKB/TrEMBL
      Q9R1R5
      Conserved Domains (1) summary
      cl25409
      Location:1179
      SDR; Short-chain dehydrogenases/reductases (SDR)
    3. NM_021557.6NP_067532.2  retinol dehydrogenase 11 isoform 1

      See identical proteins and their annotated locations for NP_067532.2

      Status: VALIDATED

      Source sequence(s)
      AK004413, AK135443, BU053368
      Consensus CDS
      CCDS36480.1
      UniProtKB/Swiss-Prot
      Q3UXM9, Q9D0U5, Q9QYF1
      UniProtKB/TrEMBL
      Q9R1R9
      Related
      ENSMUSP00000124066.2, ENSMUST00000161204.8
      Conserved Domains (2) summary
      PRK06197
      Location:38311
      PRK06197; short chain dehydrogenase; Provisional
      cl21454
      Location:38306
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      79221007..79238629 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)