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    Mdfi MyoD family inhibitor [ Mus musculus (house mouse) ]

    Gene ID: 17240, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Mdfiprovided by MGI
    Official Full Name
    MyoD family inhibitorprovided by MGI
    Primary source
    MGI:MGI:107687
    See related
    Ensembl:ENSMUSG00000032717 AllianceGenome:MGI:107687
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    I-mf; I-mfa
    Summary
    Enables DNA-binding transcription factor binding activity. Involved in several processes, including dorsal/ventral axis specification; negative regulation of transcription by RNA polymerase II; and regulation of signal transduction. Acts upstream of or within embryonic skeletal system morphogenesis and trophoblast giant cell differentiation. Located in nucleus. Is expressed in medulla oblongata basal plate mantle layer; placenta; sensory organ; skeleton; and trophectoderm. Orthologous to human MDFI (MyoD family inhibitor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in limb E14.5 (RPKM 46.3), ovary adult (RPKM 39.9) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mdfi in Genome Data Viewer
    Location:
    17 C; 17 23.99 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (48126253..48145616, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (47815328..47834691, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10960 Neighboring gene STARR-positive B cell enhancer ABC_E5617 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:47876786-47876895 Neighboring gene progastricsin (pepsinogen C) Neighboring gene transcription factor EB Neighboring gene STARR-positive B cell enhancer ABC_E2491 Neighboring gene STARR-positive B cell enhancer ABC_E5618 Neighboring gene STARR-seq mESC enhancer starr_42729 Neighboring gene predicted gene, 25201 Neighboring gene nuclear encoded rRNA 5S 28

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The inhibitor of MyoD Family A (I-MFA) regulates megakaryocyte lineage commitment and terminal differentiation. Houser JS, et al. Blood Cells Mol Dis, 2023 Sep. PMID 37267696
    2. Inhibitor of myogenic differentiation family isoform a, a new positive regulator of fibronectin production by glomerular mesangial cells. Shotorbani PY, et al. Am J Physiol Renal Physiol, 2020 Mar 1. PMID 31984795, Free PMC Article
    3. A TRPC1 protein-dependent pathway regulates osteoclast formation and function. Ong EC, et al. J Biol Chem, 2013 Aug 2. PMID 23770672, Free PMC Article
    4. Beta-catenin relieves I-mfa-mediated suppression of LEF-1 in mammalian cells. Pan W, et al. J Cell Sci, 2006 Dec 1. PMID 17090604
    5. The gene encoding I-mf (Mdfi) maps to human chromosome 6p21 and mouse chromosome 17. Kraut N. Mamm Genome, 1997 Aug. PMID 9250874

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The inhibitor of MyoD Family A (I-MFA) regulates megakaryocyte lineage commitment and terminal differentiation.
      Title: The inhibitor of MyoD Family A (I-MFA) regulates megakaryocyte lineage commitment and terminal differentiation.
    2. These results suggest that I-mfa, increased by high glucose/diabetes through the production of reactive oxygen species, stimulates fibronectin production by mesangial cells.
      Title: Inhibitor of myogenic differentiation family isoform a, a new positive regulator of fibronectin production by glomerular mesangial cells.
    3. I-mfa functions as a molecular switch to suppress the store dependence of TRPC1
      Title: Inhibitor of myogenic family, a novel suppressor of store-operated currents through an interaction with TRPC1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dorsal/ventral axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryonic skeletal system morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of JNK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within trophoblast giant cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    myoD family inhibitor
    Names
    myogenic repressor I-mf

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109973.2 → NP_001103443.1  myoD family inhibitor isoform 1

      See identical proteins and their annotated locations for NP_001103443.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longest transcript. Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AA048074, AA049446, AC113536, AI325040, AV360686, BY097762, CX564914, W65565
      Consensus CDS
      CCDS50134.1
      UniProtKB/Swiss-Prot
      P70331
      Related
      ENSMUSP00000069915.7, ENSMUST00000066368.13
      Conserved Domains (1) summary
      pfam15316
      Location:87 → 246
      MDFI; MyoD family inhibitor

    2. NM_001276390.1 → NP_001263319.1  myoD family inhibitor isoform 1

      See identical proteins and their annotated locations for NP_001263319.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 5' exon structure and differs in the 5' UTR compared to variant 2. Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AA049446, AC113536, AI325040, BQ832230, CX564914, W54345, W65565
      Consensus CDS
      CCDS50134.1
      UniProtKB/Swiss-Prot
      P70331
      Conserved Domains (1) summary
      pfam15316
      Location:87 → 246
      MDFI; MyoD family inhibitor

    3. NM_001276391.1 → NP_001263320.1  myoD family inhibitor isoform 2 precursor

      See identical proteins and their annotated locations for NP_001263320.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate 5' exon structure, differs in the 5' UTR, contains an alternate exon in the 5' coding region and uses a downstream start codon compared to variant 2. It encodes isoform 2 which is longer and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AA049446, AC113536, AI325040, CX564914, W54345, W65565
      Conserved Domains (1) summary
      pfam15316
      Location:73 → 250
      MDFI; MyoD family inhibitor

    4. NM_010783.3 → NP_034913.2  myoD family inhibitor isoform 1

      See identical proteins and their annotated locations for NP_034913.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate 5' exon structure and differs in the 5' UTR compared to variant 2. Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AA049446, AC113536, AI325040, CX564914, W54345, W65565
      Consensus CDS
      CCDS50134.1
      UniProtKB/Swiss-Prot
      P70331
      Related
      ENSMUSP00000037888.8, ENSMUST00000035375.14
      Conserved Domains (1) summary
      pfam15316
      Location:87 → 246
      MDFI; MyoD family inhibitor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      48126253..48145616 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523742.2 → XP_006523805.2  myoD family inhibitor isoform X1

      See identical proteins and their annotated locations for XP_006523805.2

      Conserved Domains (1) summary
      pfam15316
      Location:73 → 250
      MDFI; MyoD family inhibitor

    2. XM_006523744.5 → XP_006523807.1  myoD family inhibitor isoform X2

      See identical proteins and their annotated locations for XP_006523807.1

      UniProtKB/Swiss-Prot
      P70330, P70331, P70332, Q5XK64, Q99JM9
      Conserved Domains (1) summary
      pfam15316
      Location:68 → 158
      MDFI; MyoD family inhibitor

    3. XM_006523745.5 → XP_006523808.1  myoD family inhibitor isoform X2

      See identical proteins and their annotated locations for XP_006523808.1

      UniProtKB/Swiss-Prot
      P70330, P70331, P70332, Q5XK64, Q99JM9
      Conserved Domains (1) summary
      pfam15316
      Location:68 → 158
      MDFI; MyoD family inhibitor

    4. XM_006523743.5 → XP_006523806.1  myoD family inhibitor isoform X2

      See identical proteins and their annotated locations for XP_006523806.1

      UniProtKB/Swiss-Prot
      P70330, P70331, P70332, Q5XK64, Q99JM9
      Related
      ENSMUST00000140234.2
      Conserved Domains (1) summary
      pfam15316
      Location:68 → 158
      MDFI; MyoD family inhibitor
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P70331.1 GenPept UniProtKB/Swiss-Prot:P70331

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