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    Mcm6 minichromosome maintenance complex component 6 [ Mus musculus (house mouse) ]

    Gene ID: 17219, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Mcm6provided by MGI
    Official Full Name
    minichromosome maintenance complex component 6provided by MGI
    Primary source
    MGI:MGI:1298227
    See related
    Ensembl:ENSMUSG00000026355 AllianceGenome:MGI:1298227
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mcmd6; ASP-l1; D1Wsu22e
    Summary
    Enables single-stranded DNA binding activity. Contributes to DNA helicase activity. Acts upstream of or within DNA unwinding involved in DNA replication. Located in nucleus. Is expressed in several structures, including brain; eye; future brain; genitourinary system; and limb. Orthologous to human MCM6 (minichromosome maintenance complex component 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver E14 (RPKM 53.6), liver E14.5 (RPKM 45.3) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 E3; 1 55.8 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (128259312..128287442, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (128331575..128359705, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41949 Neighboring gene UBX domain protein 4 Neighboring gene lactase Neighboring gene STARR-positive B cell enhancer ABC_E7743 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:130255918-130256027 Neighboring gene STARR-positive B cell enhancer ABC_E2006 Neighboring gene STARR-positive B cell enhancer ABC_E8774 Neighboring gene STARR-positive B cell enhancer mm9_chr1:130268768-130269068 Neighboring gene aspartyl-tRNA synthetase 1 Neighboring gene STARR-seq mESC enhancer starr_02162 Neighboring gene STARR-seq mESC enhancer starr_02163 Neighboring gene STARR-positive B cell enhancer ABC_E1229 Neighboring gene predicted gene, 23902

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Accumulation and dynamics of proteins of the MCM family during mouse oogenesis and the first embryonic cell cycle. Swiech L, et al. Int J Dev Biol, 2007. PMID 17554680
    2. Structural basis for inhibition of the replication licensing factor Cdt1 by geminin. Lee C, et al. Nature, 2004 Aug 19. PMID 15286659
    3. Mouse MCM proteins: complex formation and transportation to the nucleus. Kimura H, et al. Genes Cells, 1996 Nov. PMID 9077461
    4. Deregulated Cdc6 inhibits DNA replication and suppresses Cdc7-mediated phosphorylation of Mcm2-7 complex. Kundu LR, et al. Nucleic Acids Res, 2010 Sep. PMID 20421204, Free PMC Article
    5. Cdt1 forms a complex with the minichromosome maintenance protein (MCM) and activates its helicase activity. You Z, et al. J Biol Chem, 2008 Sep 5. PMID 18606811, Free PMC Article

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. UBE3A and MCM6 synergistically regulate the proliferation and migration of lung adenocarcinoma cells.
      Title: UBE3A and MCM6 synergistically regulate the proliferation and migration of lung adenocarcinoma cells.
    2. DNA binding and helicase activities of Mcm4/6/7 are significantly stimulated by Cdt1
      Title: Cdt1 forms a complex with the minichromosome maintenance protein (MCM) and activates its helicase activity.
    3. Accumulation and dynamics of Mcm6 are described during oogenesis and the first embryonic cell cycle.
      Title: Accumulation and dynamics of proteins of the MCM family during mouse oogenesis and the first embryonic cell cycle.
    4. Substrate preference and helicase actions of mouse MCM4/6/7 helicase complexes.
      Title: DNA binding and helicase actions of mouse MCM4/6/7 helicase.
    5. role of subunits in dna helicase activity
      Title: Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to DNA helicase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to DNA helicase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    contributes_to DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to single-stranded 3'-5' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to single-stranded DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables single-stranded DNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA unwinding involved in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within DNA unwinding involved in DNA replication IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in DNA unwinding involved in DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via break-induced replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in premeiotic DNA replication NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CMG complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of MCM complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MCM complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of MCM complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA replication licensing factor MCM6
    Names
    mini chromosome maintenance deficient 6
    minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe)
    NP_001300624.1
    NP_032593.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313695.1 → NP_001300624.1  DNA replication licensing factor MCM6 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate segment in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a shorter, distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK078126, AK145520, BE447550, BY073760, CX202118
      Consensus CDS
      CCDS83586.1
      UniProtKB/TrEMBL
      Q3UC10, Q3ULG5
      Related
      ENSMUSP00000140308.2, ENSMUST00000190495.2
      Conserved Domains (3) summary
      smart00350
      Location:119 → 657
      MCM; minichromosome maintenance proteins
      pfam14551
      Location:29 → 139
      MCM_N; MCM N-terminal domain
      cl21455
      Location:447 → 534
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_008567.2 → NP_032593.1  DNA replication licensing factor MCM6 isoform 1

      See identical proteins and their annotated locations for NP_032593.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK146770, BE447550, BY073760
      Consensus CDS
      CCDS15252.1
      UniProtKB/Swiss-Prot
      P97311, Q80YQ7
      UniProtKB/TrEMBL
      Q3UC10, Q542I2
      Related
      ENSMUSP00000027601.5, ENSMUST00000027601.11
      Conserved Domains (3) summary
      smart00350
      Location:119 → 657
      MCM; minichromosome maintenance proteins
      pfam14551
      Location:29 → 139
      MCM_N; MCM N-terminal domain
      cl21455
      Location:447 → 534
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      128259312..128287442 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97311.1 GenPept UniProtKB/Swiss-Prot:P97311

    Gene LinkOut

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