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    Maz MYC-associated zinc finger protein (purine-binding transcription factor) [ Mus musculus (house mouse) ]

    Gene ID: 17188, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Mazprovided by MGI
    Official Full Name
    MYC-associated zinc finger protein (purine-binding transcription factor)provided by MGI
    Primary source
    MGI:MGI:1338823
    See related
    Ensembl:ENSMUSG00000030678 AllianceGenome:MGI:1338823
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MAZI; PUR1; Pur-1; SAF-1; SAF-2
    Summary
    Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including genitourinary system; hemolymphoid system; limb; nervous system; and retina. Orthologous to human MAZ (MYC associated zinc finger protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 242.4), adrenal adult (RPKM 140.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 F3; 7 69.28 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126621306..126626177, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127021450..127027188, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2850 Neighboring gene PAXIP1 associated glutamate rich protein 1A Neighboring gene proline-rich transmembrane protein 2 Neighboring gene predicted gene, 53372 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134167876-134168063 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134170996-134171192 Neighboring gene STARR-seq mESC enhancer starr_20164 Neighboring gene kinesin family member 22 Neighboring gene STARR-positive B cell enhancer ABC_E9708 Neighboring gene zymogen granule protein 16

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Structural organization and expression of the mouse gene for Pur-1, a highly conserved homolog of the human MAZ gene. Song J, et al. Eur J Biochem, 1999 Feb. PMID 10092852
    2. CRISPR and biochemical screens identify MAZ as a cofactor in CTCF-mediated insulation at Hox clusters. Ortabozkoyun H, et al. Nat Genet, 2022 Feb. PMID 35145304, Free PMC Article
    3. Regulation of neural stem cell differentiation by transcription factors HNF4-1 and MAZ-1. Wang J, et al. Mol Neurobiol, 2013 Feb. PMID 22944911
    4. Quantitative proteomic identification of MAZ as a transcriptional regulator of muscle-specific genes in skeletal and cardiac myocytes. Himeda CL, et al. Mol Cell Biol, 2008 Oct. PMID 18710939, Free PMC Article
    5. Pur-1, a zinc-finger protein that binds to purine-rich sequences, transactivates an insulin promoter in heterologous cells. Kennedy GC, et al. Proc Natl Acad Sci U S A, 1992 Dec 1. PMID 1454839, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CRISPR and biochemical screens identify MAZ as a cofactor in CTCF-mediated insulation at Hox clusters.
      Title: CRISPR and biochemical screens identify MAZ as a cofactor in CTCF-mediated insulation at Hox clusters.
    2. The transcription factor Maz is essential for normal eye development.
      Title: The transcription factor Maz is essential for normal eye development.
    3. myc-associated zinc finger (MAZ) protein was essential for HIF2alpha activation of the Cav1 promoter.
      Title: Hypoxia-inducible factor/MAZ-dependent induction of caveolin-1 regulates colon permeability through suppression of occludin, leading to hypoxia-induced inflammation.
    4. HNF4-1 and MAZ-1 regulate the expression of Rho-GDIgamma and contribute to the differentiation of neural stem cells.
      Title: Regulation of neural stem cell differentiation by transcription factors HNF4-1 and MAZ-1.
    5. These data support a transcription mechanism for murine KRAS that involves MAZ, PARP-1 and duplex-quadruplex conformational changes in the promoter G-rich nuclease hypersensitive element.
      Title: The KRAS promoter responds to Myc-associated zinc finger and poly(ADP-ribose) polymerase 1 proteins, which recognize a critical quadruplex-forming GA-element.
    6. These findings are consistent with a previously unrecognized role for MAZ in muscle gene regulation.
      Title: Quantitative proteomic identification of MAZ as a transcriptional regulator of muscle-specific genes in skeletal and cardiac myocytes.
    7. SAF-1 induces VEGF transcription by directly binding to its promoter; markedly higher levels of SAF-1 interaction with the VEGF promoter was detected in the cartilage tissues of arthritic mice as well as human osteoarthritic patients.
      Title: Vascular endothelial growth factor expression in arthritic joint is regulated by SAF-1 transcription factor.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in termination of RNA polymerase II transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    myc-associated zinc finger protein
    Names
    purine-binding transcription factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001372521.1 → NP_001359450.1  myc-associated zinc finger protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC122863
      UniProtKB/Swiss-Prot
      P56671, Q9R1W0
      UniProtKB/TrEMBL
      A0A0U1RNL1
      Related
      ENSMUSP00000145610.2, ENSMUST00000206254.2
      Conserved Domains (3) summary
      COG5048
      Location:254 → 302
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:280 → 337
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:258 → 278
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001372522.1 → NP_001359451.1  myc-associated zinc finger protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122863
      Consensus CDS
      CCDS90332.1
      UniProtKB/Swiss-Prot
      P56671, Q9R1W0
      UniProtKB/TrEMBL
      A0A0U1RNL9
      Conserved Domains (2) summary
      COG5189
      Location:303 → 360
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:281 → 301
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001372523.1 → NP_001359452.1  myc-associated zinc finger protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122863
      Consensus CDS
      CCDS90332.1
      UniProtKB/Swiss-Prot
      P56671, Q9R1W0
      UniProtKB/TrEMBL
      A0A0U1RNL9
      Related
      ENSMUSP00000145619.2, ENSMUST00000205568.2
      Conserved Domains (2) summary
      COG5189
      Location:303 → 360
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:281 → 301
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. NM_001412678.1 → NP_001399607.1  myc-associated zinc finger protein isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC122863

    5. NM_001412679.1 → NP_001399608.1  myc-associated zinc finger protein isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC122863

    6. NM_001412680.1 → NP_001399609.1  myc-associated zinc finger protein isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC122863

    7. NM_001412681.1 → NP_001399610.1  myc-associated zinc finger protein isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC122863

    8. NM_010772.2 → NP_034902.1  myc-associated zinc finger protein isoform 1

      See identical proteins and their annotated locations for NP_034902.1

      Status: VALIDATED

      Source sequence(s)
      AC122863
      Consensus CDS
      CCDS40137.1
      UniProtKB/Swiss-Prot
      P56671, Q9R1W0
      UniProtKB/TrEMBL
      F8VPK3
      Related
      ENSMUSP00000032916.5, ENSMUST00000032916.6
      Conserved Domains (2) summary
      COG5189
      Location:303 → 360
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:281 → 301
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RNA

    1. NR_164184.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC122863

    2. NR_182025.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC122863

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      126621306..126626177 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A47236 GenPept UniProt:A47236
    P56671.1 GenPept UniProtKB/Swiss-Prot:P56671

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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