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    Matn4 matrilin 4 [ Mus musculus (house mouse) ]

    Gene ID: 17183, updated on 16-Apr-2024

    Summary

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    Official Symbol
    Matn4provided by MGI
    Official Full Name
    matrilin 4provided by MGI
    Primary source
    MGI:MGI:1328314
    See related
    Ensembl:ENSMUSG00000016995 AllianceGenome:MGI:1328314
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    matrilin-4
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be an extracellular matrix structural constituent. Acts upstream of or within response to axon injury. Located in collagen-containing extracellular matrix. Is expressed in several structures, including bone; brain; connective tissue; respiratory system; and sensory organ. Orthologous to human MATN4 (matrilin 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in limb E14.5 (RPKM 116.8), lung adult (RPKM 38.5) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 H3; 2 85.16 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (164231313..164247080, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (164389393..164405160, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene seminal vesicle secretory protein 5 Neighboring gene microRNA 7678 Neighboring gene STARR-seq mESC enhancer starr_06324 Neighboring gene secretory leukocyte peptidase inhibitor Neighboring gene STARR-positive B cell enhancer ABC_E6015 Neighboring gene recombination signal binding protein for immunoglobulin kappa J region-like Neighboring gene STARR-positive B cell enhancer ABC_E4517 Neighboring gene STARR-positive B cell enhancer ABC_E6016 Neighboring gene STARR-seq mESC enhancer starr_06326 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:164266728-164266915 Neighboring gene syndecan 4 Neighboring gene STARR-seq mESC enhancer starr_06330 Neighboring gene STARR-positive B cell enhancer ABC_E7884 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:164286295-164286478 Neighboring gene SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae) Neighboring gene transformation related protein 53 target 5 Neighboring gene dysbindin domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Matrilin-4, a new member of the matrilin family of extracellular matrix proteins. Wagener R, et al. FEBS Lett, 1998 Sep 25. PMID 9771906
    2. Matrilin-4 is processed by ADAMTS-5 in late Golgi vesicles present in growth plate chondrocytes of defined differentiation state. Groma G, et al. Matrix Biol, 2011 May. PMID 21539915
    3. Genomic organisation, alternative splicing and primary structure of human matrilin-4. Wagener R, et al. FEBS Lett, 1998 Nov 6. PMID 9827539
    4. Mice Lacking the Matrilin Family of Extracellular Matrix Proteins Develop Mild Skeletal Abnormalities and Are Susceptible to Age-Associated Osteoarthritis. Li P, et al. Int J Mol Sci, 2020 Jan 19. PMID 31963938, Free PMC Article
    5. Expression of matrilins during maturation of mouse skeletal tissues. Klatt AR, et al. Matrix Biol, 2002 Apr. PMID 12009334

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Matn4 and cytokine receptor CXCR4 involved in the regulation of hematopoietic stem cell proliferation and expansion under acute stress.
      Title: Extracellular matrix protein Matrilin-4 regulates stress-induced HSC proliferation via CXCR4.
    2. Matrilin-4 is processed by ADAMTS-5 in late Golgi vesicles present in growth plate chondrocytes of defined differentiation state
      Title: Matrilin-4 is processed by ADAMTS-5 in late Golgi vesicles present in growth plate chondrocytes of defined differentiation state.
    3. Expression of matrilin-4 during maturation of mouse skeletal tissues
      Title: Expression of matrilins during maturation of mouse skeletal tissues.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables extracellular matrix structural constituent RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in extracellular matrix organization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to axon injury IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix HDA PubMed 
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in collagen-containing extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of matrilin complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    matrilin-4
    Names
    MAT-4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252563.1 → NP_001239492.1  matrilin-4 precursor

      See identical proteins and their annotated locations for NP_001239492.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK041073, AL590429, BC036558
      Consensus CDS
      CCDS17034.1
      UniProtKB/Swiss-Prot
      O89029, O89030, Q9QWS3
      UniProtKB/TrEMBL
      F2Z3U4
      Related
      ENSMUSP00000099393.2, ENSMUST00000103104.2
      Conserved Domains (2) summary
      cd01475
      Location:33 → 255
      vWA_Matrilin; VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. ...
      pfam14670
      Location:262 → 297
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    2. NM_013592.4 → NP_038620.2  matrilin-4 precursor

      See identical proteins and their annotated locations for NP_038620.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK041073, AL590429
      Consensus CDS
      CCDS17034.1
      UniProtKB/Swiss-Prot
      O89029, O89030, Q9QWS3
      UniProtKB/TrEMBL
      F2Z3U4
      Related
      ENSMUSP00000099392.4, ENSMUST00000103103.10
      Conserved Domains (2) summary
      cd01475
      Location:33 → 255
      vWA_Matrilin; VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. ...
      pfam14670
      Location:262 → 297
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      164231313..164247080 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O89029.1 GenPept UniProtKB/Swiss-Prot:O89029

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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