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    Matk megakaryocyte-associated tyrosine kinase [ Mus musculus (house mouse) ]

    Gene ID: 17179, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Matkprovided by MGI
    Official Full Name
    megakaryocyte-associated tyrosine kinaseprovided by MGI
    Primary source
    MGI:MGI:99259
    See related
    Ensembl:ENSMUSG00000004933 AllianceGenome:MGI:99259
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CHK; HYL; Ntk; p56ntk
    Summary
    Predicted to enable non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in protein phosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be located in cytoplasm and membrane. Is expressed in brain; gonad; hemolymphoid system gland; and intestine. Orthologous to human MATK (megakaryocyte-associated tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cortex adult (RPKM 63.6), frontal lobe adult (RPKM 48.8) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 39.72 cM; 10 C1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (81088769..81098819)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (81252935..81262985)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene ataxia, cerebellar, Cayman type, opposite strand Neighboring gene ataxia, cerebellar, Cayman type Neighboring gene zinc finger RNA binding protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E6886 Neighboring gene mitochondrial ribosomal protein L54 Neighboring gene amyloid beta precursor protein binding family A member 3 Neighboring gene microRNA 3057

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. c-Src-Dependent and -Independent Functions of Matk in Osteoclasts and Osteoblasts. Kim JH, et al. J Immunol, 2018 Apr 1. PMID 29440352
    2. Analysis of CSK homologous kinase (CHK/HYL) in hematopoiesis by utilizing gene knockout mice. Hamaguchi I, et al. Biochem Biophys Res Commun, 1996 Jul 5. PMID 8694808
    3. [VNK--a new gene for nonreceptor protein-tyrosine kinase, expressed in the murine brain and hematopoietic system]. Ershler MA, et al. Dokl Akad Nauk, 1994 Dec. PMID 7874011
    4. Structure and developmental regulation of the murine ctk gene. Brinkley PM, et al. Gene, 1995 Oct 3. PMID 7590263
    5. Genomic structure and alternative splicing of the murine bhk/ctk/ntk gene. Ershler MA, et al. FEBS Lett, 1995 Nov 13. PMID 7498479

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (3)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC130505

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    megakaryocyte-associated tyrosine-protein kinase
    Names
    Csk homologous kinase
    protein kinase NTK
    tyrosine protein kinase
    tyrosine-protein kinase CTK
    NP_001272782.1
    NP_001272783.1
    NP_001272784.1
    NP_034898.1
    XP_006513357.1
    XP_006513358.1
    XP_006513361.1
    XP_006513362.1
    XP_011241678.1
    XP_011241679.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285853.2 → NP_001272782.1  megakaryocyte-associated tyrosine-protein kinase isoform 2

      See identical proteins and their annotated locations for NP_001272782.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a distinct 5' UTR, lacks an in-frame portion of the 5' coding region and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 2 and 6 both encode the same isoform (2).
      Source sequence(s)
      AC155932
      Consensus CDS
      CCDS70077.1
      UniProtKB/TrEMBL
      D3Z4T5, P70223, Q9D6H7
      Related
      ENSMUSP00000113043.2, ENSMUST00000121205.8
      Conserved Domains (3) summary
      cd09937
      Location:77 → 174
      SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
      cl17036
      Location:9 → 67
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:187 → 440
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001285854.2 → NP_001272783.1  megakaryocyte-associated tyrosine-protein kinase isoform 3

      See identical proteins and their annotated locations for NP_001272783.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1. Variants 3, 4, and 7 all encode the same isoform (3).
      Source sequence(s)
      AC155932
      Consensus CDS
      CCDS70078.1
      UniProtKB/TrEMBL
      A0A0R4J1P8, P70223, Q9D6H7
      Related
      ENSMUSP00000100965.4, ENSMUST00000105328.10
      Conserved Domains (3) summary
      cd09937
      Location:76 → 173
      SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
      cl17036
      Location:8 → 66
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:186 → 439
      PKc_like; Protein Kinases, catalytic domain

    3. NM_001285855.2 → NP_001272784.1  megakaryocyte-associated tyrosine-protein kinase isoform 3

      See identical proteins and their annotated locations for NP_001272784.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1. Variants 3, 4, and 7 all encode the same isoform (3).
      Source sequence(s)
      AC155932
      Consensus CDS
      CCDS70078.1
      UniProtKB/TrEMBL
      A0A0R4J1P8, P70223, Q9D6H7
      Related
      ENSMUSP00000113576.2, ENSMUST00000119547.8
      Conserved Domains (3) summary
      cd09937
      Location:76 → 173
      SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
      cl17036
      Location:8 → 66
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:186 → 439
      PKc_like; Protein Kinases, catalytic domain

    4. NM_001428580.1 → NP_001415509.1  megakaryocyte-associated tyrosine-protein kinase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC155932
      UniProtKB/TrEMBL
      A0A0R4J1N6

    5. NM_001428581.1 → NP_001415510.1  megakaryocyte-associated tyrosine-protein kinase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC155932
      UniProtKB/TrEMBL
      D3Z4T5

    6. NM_001428582.1 → NP_001415511.1  megakaryocyte-associated tyrosine-protein kinase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC155932
      UniProtKB/TrEMBL
      A0A0R4J1P8

    7. NM_010768.3 → NP_034898.1  megakaryocyte-associated tyrosine-protein kinase isoform 1

      See identical proteins and their annotated locations for NP_034898.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 5 both encode the same isoform (1).
      Source sequence(s)
      AC155932
      Consensus CDS
      CCDS24048.1
      UniProtKB/Swiss-Prot
      P41242, Q6LE90
      UniProtKB/TrEMBL
      A0A0R4J1N6
      Related
      ENSMUSP00000113221.2, ENSMUST00000117488.8
      Conserved Domains (3) summary
      cd09937
      Location:116 → 213
      SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
      cl17036
      Location:48 → 106
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:226 → 479
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      81088769..81098819
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513298.4 → XP_006513361.1  megakaryocyte-associated tyrosine-protein kinase isoform X5

      Related
      ENSMUSP00000113666.2, ENSMUST00000120265.2
      Conserved Domains (3) summary
      cd09937
      Location:77 → 174
      SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
      cl17036
      Location:9 → 67
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:187 → 440
      PKc_like; Protein Kinases, catalytic domain

    2. XM_011243376.3 → XP_011241678.1  megakaryocyte-associated tyrosine-protein kinase isoform X3

      UniProtKB/TrEMBL
      P70223, Q9D6H7
      Conserved Domains (3) summary
      cd09937
      Location:103 → 200
      SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
      cl17036
      Location:35 → 93
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:213 → 466
      PKc_like; Protein Kinases, catalytic domain

    3. XM_011243377.3 → XP_011241679.1  megakaryocyte-associated tyrosine-protein kinase isoform X4

      UniProtKB/TrEMBL
      P70223, Q9D6H7
      Conserved Domains (3) summary
      cd09937
      Location:102 → 199
      SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
      cl17036
      Location:34 → 92
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:212 → 465
      PKc_like; Protein Kinases, catalytic domain

    4. XM_006513299.4 → XP_006513362.1  megakaryocyte-associated tyrosine-protein kinase isoform X6

      Conserved Domains (3) summary
      cd09937
      Location:76 → 173
      SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
      cl17036
      Location:8 → 66
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:186 → 439
      PKc_like; Protein Kinases, catalytic domain

    5. XM_006513295.5 → XP_006513358.1  megakaryocyte-associated tyrosine-protein kinase isoform X2

      Conserved Domains (3) summary
      cd09937
      Location:116 → 213
      SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
      cl17036
      Location:48 → 106
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:226 → 479
      PKc_like; Protein Kinases, catalytic domain

    6. XM_006513294.4 → XP_006513357.1  megakaryocyte-associated tyrosine-protein kinase isoform X1

      UniProtKB/Swiss-Prot
      P41242, Q6LE90
      Conserved Domains (3) summary
      cd09937
      Location:117 → 214
      SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
      cl17036
      Location:49 → 107
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:227 → 480
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P41242.2 GenPept UniProtKB/Swiss-Prot:P41242

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