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    Slc12a8 solute carrier family 12 (potassium/chloride transporters), member 8 [ Mus musculus (house mouse) ]

    Gene ID: 171286, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Slc12a8provided by MGI
    Official Full Name
    solute carrier family 12 (potassium/chloride transporters), member 8provided by MGI
    Primary source
    MGI:MGI:2443672
    See related
    Ensembl:ENSMUSG00000035506 AllianceGenome:MGI:2443672
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CCC9; E330020C02Rik
    Summary
    Predicted to enable potassium:chloride symporter activity. Predicted to be involved in cell volume homeostasis; inorganic ion homeostasis; and inorganic ion transmembrane transport. Predicted to act upstream of or within potassium ion transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in metanephros. Orthologous to human SLC12A8 (solute carrier family 12 member 8). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in colon adult (RPKM 32.3), large intestine adult (RPKM 19.7) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    16 B3; 16 24.12 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (33337440..33484508)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (33517328..33664138)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700007L15 gene Neighboring gene STARR-seq mESC enhancer starr_40693 Neighboring gene zinc finger protein 148 Neighboring gene STARR-seq mESC enhancer starr_40697 Neighboring gene STARR-seq mESC enhancer starr_40698 Neighboring gene STARR-seq mESC enhancer starr_40700 Neighboring gene STARR-seq mESC enhancer starr_40702 Neighboring gene STARR-positive B cell enhancer ABC_E5537 Neighboring gene STARR-seq mESC enhancer starr_40703 Neighboring gene heart development protein with EGF-like domains 1 Neighboring gene STARR-positive B cell enhancer ABC_E11611 Neighboring gene STARR-seq mESC enhancer starr_40709 Neighboring gene predicted gene 15658 Neighboring gene mucin 13, epithelial transmembrane

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Slc12a8 is a nicotinamide mononucleotide transporter. Grozio A, et al. Nat Metab, 2019 Jan. PMID 31131364, Free PMC Article
    2. Slc12a8 in the lateral hypothalamus maintains energy metabolism and skeletal muscle functions during aging. Ito N, et al. Cell Rep, 2022 Jul 26. PMID 35905718
    3. Cation-chloride cotransporters and neuronal function. Blaesse P, et al. Neuron, 2009 Mar 26. PMID 19323993
    4. Gene expression in the developing mouse retina by EST sequencing and microarray analysis. Mu X, et al. Nucleic Acids Res, 2001 Dec 15. PMID 11812828, Free PMC Article
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (2)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chloride:monoatomic cation symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium:chloride symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell volume homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 12 member 8
    Names
    cation-chloride cotransporter 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083902.2 → NP_001077371.1  solute carrier family 12 member 8 isoform 2

      See identical proteins and their annotated locations for NP_001077371.1

      Status: VALIDATED

      Source sequence(s)
      AC121570, AC127412
      Consensus CDS
      CCDS37317.1
      UniProtKB/TrEMBL
      D3Z6X1
      Related
      ENSMUSP00000113633.2, ENSMUST00000119173.8
      Conserved Domains (1) summary
      TIGR00930
      Location:3 → 340
      2a30; K-Cl cotransporter

    2. NM_001370999.1 → NP_001357928.1  solute carrier family 12 member 8 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC121570, AC127412, AF319951, AK165080, BU921470
      Consensus CDS
      CCDS49834.1
      UniProtKB/Swiss-Prot
      Q3TNQ9, Q8K0M9, Q8VI23
      UniProtKB/TrEMBL
      D3Z6X1
      Related
      ENSMUSP00000112439.2, ENSMUST00000121925.8
      Conserved Domains (1) summary
      TIGR00930
      Location:34 → 420
      2a30; K-Cl cotransporter

    3. NM_134251.3 → NP_599012.2  solute carrier family 12 member 8 isoform 1

      See identical proteins and their annotated locations for NP_599012.2

      Status: VALIDATED

      Source sequence(s)
      AC121570, AC127412, AF319951, AK165080, BU921470
      Consensus CDS
      CCDS49834.1
      UniProtKB/Swiss-Prot
      Q3TNQ9, Q8K0M9, Q8VI23
      UniProtKB/TrEMBL
      D3Z6X1
      Related
      ENSMUSP00000062337.9, ENSMUST00000059056.15
      Conserved Domains (1) summary
      TIGR00930
      Location:34 → 420
      2a30; K-Cl cotransporter

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      33337440..33484508
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521823.5 → XP_006521886.1  solute carrier family 12 member 8 isoform X2

      UniProtKB/TrEMBL
      D3Z6X1
      Conserved Domains (1) summary
      TIGR00930
      Location:34 → 420
      2a30; K-Cl cotransporter

    2. XM_036159807.1 → XP_036015700.1  solute carrier family 12 member 8 isoform X6

      UniProtKB/TrEMBL
      D3Z6X1
      Related
      ENSMUSP00000113164.2, ENSMUST00000122427.8
      Conserved Domains (1) summary
      TIGR00930
      Location:34 → 420
      2a30; K-Cl cotransporter

    3. XM_030248992.2 → XP_030104852.1  solute carrier family 12 member 8 isoform X3

      Conserved Domains (1) summary
      TIGR00930
      Location:34 → 382
      2a30; K-Cl cotransporter

    4. XM_006521825.4 → XP_006521888.1  solute carrier family 12 member 8 isoform X4

      UniProtKB/TrEMBL
      D3Z6X1
      Conserved Domains (1) summary
      TIGR00930
      Location:34 → 371
      2a30; K-Cl cotransporter

    5. XM_030248993.2 → XP_030104853.1  solute carrier family 12 member 8 isoform X5

      Conserved Domains (1) summary
      TIGR00930
      Location:3 → 351
      2a30; K-Cl cotransporter

    6. XM_006521822.4 → XP_006521885.1  solute carrier family 12 member 8 isoform X1

      See identical proteins and their annotated locations for XP_006521885.1

      Conserved Domains (1) summary
      TIGR00930
      Location:3 → 389
      2a30; K-Cl cotransporter

    7. XM_006521821.3 → XP_006521884.1  solute carrier family 12 member 8 isoform X1

      See identical proteins and their annotated locations for XP_006521884.1

      Conserved Domains (1) summary
      TIGR00930
      Location:3 → 389
      2a30; K-Cl cotransporter

    8. XM_006521827.3 → XP_006521890.1  solute carrier family 12 member 8 isoform X7

      UniProtKB/TrEMBL
      D3Z3V1
      Conserved Domains (1) summary
      TIGR00930
      Location:1 → 286
      2a30; K-Cl cotransporter

    9. XM_036159808.1 → XP_036015701.1  solute carrier family 12 member 8 isoform X8

      UniProtKB/TrEMBL
      D3Z3V1
      Related
      ENSMUSP00000113901.2, ENSMUST00000122314.8
      Conserved Domains (1) summary
      TIGR00930
      Location:11 → 186
      2a30; K-Cl cotransporter

    10. XM_030248994.2 → XP_030104854.1  solute carrier family 12 member 8 isoform X9

      UniProtKB/TrEMBL
      D3Z3V1
      Conserved Domains (1) summary
      TIGR00930
      Location:4 → 97
      2a30; K-Cl cotransporter
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VI23.2 GenPept UniProtKB/Swiss-Prot:Q8VI23

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