Asic3 acid-sensing ion channel 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Asic3provided by MGI
Official Full Name: acid-sensing ion channel 3provided by MGI
Primary source: MGI:MGI:2159339
See related: Ensembl:ENSMUSG00000038276 AllianceGenome:MGI:2159339
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Accn3; TNAC1; DRASIC; SLNAC1
Summary: Enables cation channel activity and enterobactin transmembrane transporter activity. Acts upstream of or within several processes, including detection of stimulus involved in sensory perception of pain; response to acidic pH; and response to heat. Is integral component of plasma membrane. Is expressed in cranial ganglion; dorsal root ganglion; and pectoral girdle and thoracic body wall muscle. Orthologous to human ASIC3 (acid sensing ion channel subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 5 A3; 5 11.72 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (24618449..24622836)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (24413451..24417840)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Acid-sensing ion channel 3 mediates pain hypersensitivity associated with high-fat diet consumption in mice.
Title: Acid-sensing ion channel 3 mediates pain hypersensitivity associated with high-fat diet consumption in mice.
Involvement of ASIC3 and Substance P in Therapeutic Ultrasound-Mediated Analgesia in Mouse Models of Fibromyalgia.
Title: Involvement of ASIC3 and Substance P in Therapeutic Ultrasound-Mediated Analgesia in Mouse Models of Fibromyalgia.
Antibody-induced pain-like behavior and bone erosion: links to subclinical inflammation, osteoclast activity, and acid-sensing ion channel 3-dependent sensitization.
Title: Antibody-induced pain-like behavior and bone erosion: links to subclinical inflammation, osteoclast activity, and acid-sensing ion channel 3-dependent sensitization.
C-Jun N-Terminal Kinase Post-Translational Regulation of Pain-Related Acid-Sensing Ion Channels 1b and 3.
Title: C-Jun N-Terminal Kinase Post-Translational Regulation of Pain-Related Acid-Sensing Ion Channels 1b and 3.
Acid-sensing ion channels modulate bladder nociception.
Title: Acid-sensing ion channels modulate bladder nociception.
Deletion of Acid-Sensing Ion Channel 3 Relieves the Late Phase of Neuropathic Pain by Preventing Neuron Degeneration and Promoting Neuron Repair.
Title: Deletion of Acid-Sensing Ion Channel 3 Relieves the Late Phase of Neuropathic Pain by Preventing Neuron Degeneration and Promoting Neuron Repair.
ASIC3-dependent metabolomics profiling of serum and urine in a mouse model of fibromyalgia.
Title: ASIC3-dependent metabolomics profiling of serum and urine in a mouse model of fibromyalgia.
that ASIC3 plays a role in the control of bladder function by modulating the response of afferents to filling
Title: ASIC3 fine-tunes bladder sensory signaling.
High ASIC3 expression is associated with Fibromyalgia Pain.
Title: Targeting ASIC3 for Relieving Mice Fibromyalgia Pain: Roles of Electroacupuncture, Opioid, and Adenosine.
This is the first study to provide evidence that TDAG8, ASIC3 and TRPV1 regulate hyperalgesic priming of RA pain and that a transition from acute to chronic RA pain is at about 4 weeks.
Title: TDAG8, TRPV1, and ASIC3 involved in establishing hyperalgesic priming in experimental rheumatoid arthritis.

Submit: New GeneRIF Correction See all GeneRIFs (57)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC124411P1 (e-PCR)
- UniSTS:270469

AW742291 (e-PCR)
- UniSTS:207762

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enterobactin transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ligand-gated sodium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables ligand-gated sodium channel activity	ISO Inferred from Sequence Orthology more info
enables monoatomic cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables monoatomic cation channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables monoatomic cation channel activity	TAS Traceable Author Statement more info	PubMed
enables pH-gated monoatomic ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within detection of chemical stimulus involved in sensory perception	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within detection of chemical stimulus involved in sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within detection of temperature stimulus involved in sensory perception	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within detection of temperature stimulus involved in sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monoatomic cation transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within monoatomic cation transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monoatomic ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to acidic pH	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to acidic pH	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to acidic pH	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to mechanical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of sour taste	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sodium ion transport	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: acid-sensing ion channel 3

Names: acid-sensing (proton-gated) ion channel 3; amiloride-sensitive cation channel 3; dorsal root ASIC

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001310474.1 → NP_001297403.1 acid-sensing ion channel 3 isoform 2

See identical proteins and their annotated locations for NP_001297403.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, which results in a frameshift compared to variant 1. The encoded isoform (2) has a shorter, distinct C-terminus compared to isoform 1.

Source sequence(s)

AK028403, BC054460

Consensus CDS

CCDS80225.1

UniProtKB/Swiss-Prot

Q6X1Y6

Related

ENSMUSP00000039914.7, ENSMUST00000049346.10

Conserved Domains (1) summary

cl02990
Location:21 → 355

ASC; Amiloride-sensitive sodium channel
NM_183000.2 → NP_892045.2 acid-sensing ion channel 3 isoform 1

See identical proteins and their annotated locations for NP_892045.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

BC054460

Consensus CDS

CCDS51433.1

UniProtKB/Swiss-Prot

Q6X1Y6, Q7TQH4

Related

ENSMUSP00000143083.2, ENSMUST00000196296.2

Conserved Domains (1) summary

cl02990
Location:21 → 513

ASC; Amiloride-sensitive sodium channel

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

24618449..24622836

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006535637.4 → XP_006535700.1 acid-sensing ion channel 3 isoform X1

Conserved Domains (1) summary

cl02990
Location:21 → 546

ASC; Amiloride-sensitive sodium channel
XM_006535638.4 → XP_006535701.1 acid-sensing ion channel 3 isoform X2

Conserved Domains (1) summary

cl02990
Location:21 → 483

ASC; Amiloride-sensitive sodium channel
XM_017320697.3 → XP_017176186.1 acid-sensing ion channel 3 isoform X3

Conserved Domains (1) summary

cl02990
Location:21 → 355

ASC; Amiloride-sensitive sodium channel