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    Tm4sf1 transmembrane 4 superfamily member 1 [ Mus musculus (house mouse) ]

    Gene ID: 17112, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Tm4sf1provided by MGI
    Official Full Name
    transmembrane 4 superfamily member 1provided by MGI
    Primary source
    MGI:MGI:104678
    See related
    Ensembl:ENSMUSG00000027800 AllianceGenome:MGI:104678
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    L6; M3s1
    Summary
    Acts upstream of or within blastocyst formation. Predicted to be integral component of plasma membrane. Predicted to be integral component of membrane. Is expressed in cardiovascular system; early conceptus; floor plate; pancreas; and secondary oocyte. Orthologous to human TM4SF1 (transmembrane 4 L six family member 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in lung adult (RPKM 43.9), heart adult (RPKM 24.6) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tm4sf1 in Genome Data Viewer
    Location:
    3 D; 3 27.68 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (57193038..57295150, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (57285611..57387736, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_07726 Neighboring gene La ribonucleoprotein domain family, member 4 pseudogene Neighboring gene STARR-seq mESC enhancer starr_07727 Neighboring gene proliferating cell nuclear antigen pseudogene Neighboring gene microRNA 12195 Neighboring gene STARR-seq mESC enhancer starr_07730 Neighboring gene STARR-seq mESC enhancer starr_07731 Neighboring gene aldolase A, fructose-bisphosphate pseudogene Neighboring gene predicted gene, 52659 Neighboring gene transmembrane 4 superfamily member 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning of the murine counterpart of the tumor-associated antigen H-L6: epitope mapping of the human and murine L6 antigens. Edwards CP, et al. Biochemistry, 1995 Oct 3. PMID 7548016
    2. TM4SF1: a new vascular therapeutic target in cancer. Lin CI, et al. Angiogenesis, 2014 Oct. PMID 24986520, Free PMC Article
    3. Tumor-associated antigen L6 and the invasion of human lung cancer cells. Kao YR, et al. Clin Cancer Res, 2003 Jul. PMID 12855661
    4. Molecular cloning of a cDNA for rat TM4SF4, a homolog of human il-TMP (TM4SF4), and enhanced expression of the corresponding gene in regenerating rat liver(1). Liu Z, et al. Biochim Biophys Acta, 2001 Mar 19. PMID 11267677
    5. The cDNA cloning of the hamster homologue of the human L6 gene. Maruyama M, et al. Gene, 1996 Feb 12. PMID 8654959

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TAL6 may play a role in cancer invasion and metastasis
      Title: Tumor-associated antigen L6 and the invasion of human lung cancer cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within blastocyst formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane 4 L6 family member 1
    Names
    12A8 target antigen
    L6 antigen
    membrane component chromosome 3 surface marker 1 homolog
    membrane component, surface marker 1
    tumor-associated antigen L6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355130.2 → NP_001342059.1  transmembrane 4 L6 family member 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC119854
      Consensus CDS
      CCDS38433.1
      UniProtKB/Swiss-Prot
      Q3TP49, Q64302
      UniProtKB/TrEMBL
      Q3UZY2
      Related
      ENSMUSP00000029376.9, ENSMUST00000029376.13
      Conserved Domains (1) summary
      pfam05805
      Location:1 → 194
      L6_membrane; L6 membrane protein

    2. NM_001410064.1 → NP_001396993.1  transmembrane 4 L6 family member 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC119854
      UniProtKB/Swiss-Prot
      Q3TP49, Q64302
      Related
      ENSMUSP00000130999.2, ENSMUST00000171384.8

    3. NM_001410065.1 → NP_001396994.1  transmembrane 4 L6 family member 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC119854

    4. NM_001410066.1 → NP_001396995.1  transmembrane 4 L6 family member 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC119854

    5. NM_001410067.1 → NP_001396996.1  transmembrane 4 L6 family member 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC119854

    6. NM_001410068.1 → NP_001396997.1  transmembrane 4 L6 family member 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC119854

    7. NM_008536.5 → NP_032562.1  transmembrane 4 L6 family member 1 isoform 1

      See identical proteins and their annotated locations for NP_032562.1

      Status: VALIDATED

      Source sequence(s)
      AC119854
      Consensus CDS
      CCDS38433.1
      UniProtKB/Swiss-Prot
      Q3TP49, Q64302
      UniProtKB/TrEMBL
      Q3UZY2
      Related
      ENSMUSP00000143652.2, ENSMUST00000196979.5
      Conserved Domains (1) summary
      pfam05805
      Location:1 → 194
      L6_membrane; L6 membrane protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      57193038..57295150 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252446.1 → XP_030108306.1  transmembrane 4 L6 family member 1 isoform X1

      UniProtKB/Swiss-Prot
      Q3TP49, Q64302
      UniProtKB/TrEMBL
      Q3UZY2
      Conserved Domains (1) summary
      pfam05805
      Location:1 → 194
      L6_membrane; L6 membrane protein

    2. XM_030252445.2 → XP_030108305.1  transmembrane 4 L6 family member 1 isoform X1

      UniProtKB/Swiss-Prot
      Q3TP49, Q64302
      UniProtKB/TrEMBL
      Q3UZY2
      Conserved Domains (1) summary
      pfam05805
      Location:1 → 194
      L6_membrane; L6 membrane protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q64302.1 GenPept UniProtKB/Swiss-Prot:Q64302

    Gene LinkOut

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