Il17rc interleukin 17 receptor C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il17rcprovided by MGI
Official Full Name: interleukin 17 receptor Cprovided by MGI
Primary source: MGI:MGI:2159336
See related: Ensembl:ENSMUSG00000030281 AllianceGenome:MGI:2159336
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Il17rl; Gm19850; IL-17RC; IL17-RC; IL17-RL; 1110025H02Rik
Summary: Enables signaling receptor binding activity. Involved in defense response to fungus; granulocyte chemotaxis; and positive regulation of interleukin-6 production. Acts upstream of or within positive regulation of cytokine production involved in inflammatory response. Located in cell surface and plasma membrane. Is expressed in hip; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in chronic mucocutaneous candidiasis. Orthologous to human IL17RC (interleukin 17 receptor C). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in small intestine adult (RPKM 138.6), duodenum adult (RPKM 133.9) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 E3; 6 52.77 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (113448416..113460124)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (113471455..113483163)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interleukin-17 receptor C is essential for the pro-inflammatory pathogenicity of granulocyte-macrophage-colony-stimulating factor-producing T helper cells in experimental autoimmune uveitis.
Title: Interleukin-17 receptor C is essential for the pro-inflammatory pathogenicity of granulocyte-macrophage-colony-stimulating factor-producing T helper cells in experimental autoimmune uveitis.
IL-17A promotes Helicobacter pylori-induced gastric carcinogenesis via interactions with IL-17RC.
Title: IL-17A promotes Helicobacter pylori-induced gastric carcinogenesis via interactions with IL-17RC.
IL17A critically shapes the transcriptional program of fibroblasts in pancreatic cancer and switches on their protumorigenic functions.
Title: IL17A critically shapes the transcriptional program of fibroblasts in pancreatic cancer and switches on their protumorigenic functions.
thermogenic adipose tissue from mice as a model system to show that T cells, specifically gammadelta T cells, have a crucial role in promoting sympathetic innervation, at least in part by driving the expression of TGFbeta1 in parenchymal cells via the IL-17 receptor C
Title: γδ T cells and adipocyte IL-17RC control fat innervation and thermogenesis.
The IL17RC gene may promote osteogenesis through the IL17 signaling pathway and may thus be involved in the process of ectopic osteogenesis in thoracic ossification of the posterior longitudinal ligament.
Title: Potential role of the IL17RC gene in the thoracic ossification of the posterior longitudinal ligament.
Study reveals a critical role of IL-17RC in maintaining baseline A20 production and a novel role of the IL-17RC-A20 axis in controlling JNK isoform-dependent tumor-specific homeostatic proliferation.
Title: IL-17RC is critically required to maintain baseline A20 production to repress JNK isoform-dependent tumor-specific proliferation.
IL-17A and IL-17F exert distinct biological effects during pulmonary infection; the IL-17F/IL-17RC signaling axis has the potential to significantly worsen pathogen-associated inflammation of the lower respiratory tract.
Title: The IL-17F/IL-17RC Axis Promotes Respiratory Allergy in the Proximal Airways.
Our study shows for the first time that psoriatic inflammation leads to hepatic inflammation which results in dysregulated protein/lipid metabolism through IL-17RC/NFkappaB signaling.
Title: Psoriatic inflammation causes hepatic inflammation with concomitant dysregulation in hepatic metabolism via IL-17A/IL-17 receptor signaling in a murine model.
Expression of these mediators was confirmed in end-stage COPD. Thus, accumulation of mast cells in COPD may contribute to vascular remodeling.
Title: Increased IL-17RA and IL-17RC in End-Stage COPD and the Contribution to Mast Cell Secretion of FGF-2 and VEGF.
These data show that IL-17R signaling in the lung epithelium plays a critical role in establishing chemokine gradients that are essential for mucosal immunity against pulmonary bacterial pathogens.
Title: IL-17 Receptor Signaling in the Lung Epithelium Is Required for Mucosal Chemokine Gradients and Pulmonary Host Defense against K. pneumoniae.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (4) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables coreceptor activity	ISO Inferred from Sequence Orthology more info
enables interleukin-17 receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-17 receptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in granulocyte chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in interleukin-17A-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cytokine production involved in inflammatory response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: interleukin-17 receptor C

Names: IL-17 receptor C; IL-17RL; interleukin-17 receptor-like protein; zcytoR14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_134159.4 → NP_598920.3 interleukin-17 receptor C isoform 2

See identical proteins and their annotated locations for NP_598920.3

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate exon and uses a different splice site in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.

Source sequence(s)

AF458066, AI592368, AK075634, AW045329, BY018830

Consensus CDS

CCDS20422.1

UniProtKB/TrEMBL

F7AR97

Related

ENSMUSP00000055343.8, ENSMUST00000058300.14

Conserved Domains (2) summary

pfam08357
Location:473 → 623

SEFIR; SEFIR domain

pfam15037
Location:71 → 432

IL17_R_N; Interleukin-17 receptor extracellular region
NM_178942.1 → NP_849273.1 interleukin-17 receptor C isoform 1 precursor

See identical proteins and their annotated locations for NP_849273.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer variant and it encodes the longer protein (isoform 1).

Source sequence(s)

AF458066, AI592368, AK040950, AK075634, BY018830

UniProtKB/Swiss-Prot

G3X9C0, Q8K4C2, Q99J43

UniProtKB/TrEMBL

F7AR97

Related

ENSMUSP00000145038.2, ENSMUST00000205208.3

Conserved Domains (2) summary

pfam08357
Location:497 → 647

SEFIR; SEFIR domain

pfam15037
Location:71 → 456

IL17_R_N; Interleukin-17 receptor extracellular region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

113448416..113460124

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006505665.1 → XP_006505728.1 interleukin-17 receptor C isoform X1

See identical proteins and their annotated locations for XP_006505728.1

UniProtKB/TrEMBL

F7AR97

Conserved Domains (2) summary

pfam08357
Location:488 → 638

SEFIR; SEFIR domain

pfam15037
Location:71 → 447

IL17_R_N; Interleukin-17 receptor extracellular region
XM_006505666.1 → XP_006505729.1 interleukin-17 receptor C isoform X2

See identical proteins and their annotated locations for XP_006505729.1

UniProtKB/TrEMBL

F7AR97

Conserved Domains (2) summary

pfam08357
Location:482 → 632

SEFIR; SEFIR domain

pfam15037
Location:71 → 441

IL17_R_N; Interleukin-17 receptor extracellular region
XM_006505668.3 → XP_006505731.1 interleukin-17 receptor C isoform X4

Conserved Domains (1) summary

pfam15037
Location:71 → 371

IL17_R_N; Interleukin-17 receptor extracellular region
XM_006505667.4 → XP_006505730.1 interleukin-17 receptor C isoform X3

Conserved Domains (1) summary

pfam15037
Location:71 → 366

IL17_R_N; Interleukin-17 receptor extracellular region