Lyn LYN proto-oncogene, Src family tyrosine kinase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lynprovided by MGI
Official Full Name: LYN proto-oncogene, Src family tyrosine kinaseprovided by MGI
Primary source: MGI:MGI:96892
See related: Ensembl:ENSMUSG00000042228 AllianceGenome:MGI:96892
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hck-2; p53Lyn; p56Lyn
Summary: Enables SH3 domain binding activity and non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including immune response-regulating signaling pathway; immune system development; and regulation of signal transduction. Acts upstream of or within several processes, including B cell receptor signaling pathway; peptidyl-tyrosine phosphorylation; and regulation of release of sequestered calcium ion into cytosol. Located in several cellular components, including membrane raft; nucleus; and plasma membrane. Part of protein-containing complex. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; liver and biliary system; and nervous system. Used to study systemic lupus erythematosus. Orthologous to human LYN (LYN proto-oncogene, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in spleen adult (RPKM 46.2), lung adult (RPKM 24.2) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 A1; 4 2.05 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (3676865..3791613)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (3678068..3791612)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Conditional in vivo deletion of LYN kinase has little effect on a BRCA1 loss-of-function-associated mammary tumour model.
Title: Conditional in vivo deletion of LYN kinase has little effect on a BRCA1 loss-of-function-associated mammary tumour model.
Regulation of Microglial Signaling by Lyn and SHIP-1 in the Steady-State Adult Mouse Brain.
Title: Regulation of Microglial Signaling by Lyn and SHIP-1 in the Steady-State Adult Mouse Brain.
STAP-2 negatively regulates BCR-mediated B cell activation by recruiting tyrosine-protein kinase CSK to LYN.
Title: STAP-2 negatively regulates BCR-mediated B cell activation by recruiting tyrosine-protein kinase CSK to LYN.
T-bet-expressing B cells contribute to the autoreactive plasma cell pool in Lyn[-/-] mice.
Title: T-bet-expressing B cells contribute to the autoreactive plasma cell pool in Lyn(-/-) mice.
Lyn attenuates sepsis-associated acute kidney injury by inhibition of phospho-STAT3 and apoptosis.
Title: Lyn attenuates sepsis-associated acute kidney injury by inhibition of phospho-STAT3 and apoptosis.
Brain-derived neurotrophic factor regulates LYN kinase-mediated myosin light chain kinase activation to modulate nonmuscle myosin II activity in hippocampal neurons.
Title: Brain-derived neurotrophic factor regulates LYN kinase-mediated myosin light chain kinase activation to modulate nonmuscle myosin II activity in hippocampal neurons.
Deep Phenotyping by Mass Cytometry and Single-Cell RNA-Sequencing Reveals LYN-Regulated Signaling Profiles Underlying Monocyte Subset Heterogeneity and Lifespan.
Title: Deep Phenotyping by Mass Cytometry and Single-Cell RNA-Sequencing Reveals LYN-Regulated Signaling Profiles Underlying Monocyte Subset Heterogeneity and Lifespan.
Depletion of Csk preferentially reduces the protein level of LynA in a Cbl-dependent manner in cancer cells.
Title: Depletion of Csk preferentially reduces the protein level of LynA in a Cbl-dependent manner in cancer cells.
CARD9 mediates dendritic cell-induced development of Lyn deficiency-associated autoimmune and inflammatory diseases.
Title: CARD9 mediates dendritic cell-induced development of Lyn deficiency-associated autoimmune and inflammatory diseases.
Data suggest that cell-specific E3 ubiquitin ligase c-Cbl (c-Cbl) expression builds cell specificity into the LYN proto-oncogene Src family tyrosine kinase tyrosine-protein kinase (LynA) checkpoint.
Title: Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells.

Submit: New GeneRIF Correction See all GeneRIFs (113)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (8) 1 citation
Chemically induced (ENU) (8) 1 citation
Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124610 (e-PCR)
- UniSTS:161432

RH125723 (e-PCR)
- UniSTS:142496

RH125697 (e-PCR)
- UniSTS:162468

RH124629 (e-PCR)
- UniSTS:161451

Lyn (e-PCR), detects polymorphism
- UniSTS:143806

NoName (e-PCR)
- UniSTS:224214

M-09853 (e-PCR)
- UniSTS:207589

M57696 (e-PCR)
- UniSTS:159212

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables SH3 domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables ephrin receptor binding	ISO Inferred from Sequence Orthology more info
enables erythropoietin receptor binding	TAS Traceable Author Statement more info	PubMed
enables gamma-tubulin binding	ISO Inferred from Sequence Orthology more info
enables glycosphingolipid binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables non-membrane spanning protein tyrosine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables non-membrane spanning protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol 3-kinase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphoprotein binding	ISO Inferred from Sequence Orthology more info
enables phosphorylation-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables platelet-derived growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	EXP Inferred from Experiment more info	PubMed
enables protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activity	TAS Traceable Author Statement more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within B cell receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within B cell receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in C-X-C chemokine receptor CXCR4 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in DNA damage checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in Fc receptor mediated inhibitory signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Fc receptor mediated stimulatory signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in Fc receptor mediated stimulatory signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to retinoic acid	ISO Inferred from Sequence Orthology more info
involved_in dendritic cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendritic cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eosinophil differentiation	ISO Inferred from Sequence Orthology more info
involved_in erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hematopoietic progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in hemoglobin biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in histamine secretion by mast cell	ISO Inferred from Sequence Orthology more info
involved_in immune response-regulating cell surface receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in interleukin-5-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in lipopolysaccharide-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of B cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of MAP kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intracellular signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mast cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of myeloid leukocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of toll-like receptor 2 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of toll-like receptor 4 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-tyrosine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in platelet degranulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Fc receptor mediated stimulatory signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of dendritic cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mast cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of oligodendrocyte progenitor proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tyrosine phosphorylation of STAT protein	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein autophosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of B cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of B cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of B cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mast cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mast cell degranulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of monocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in regulation of platelet aggregation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of release of sequestered calcium ion into cytosol	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in response to hormone	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in tolerance induction to self antigen	IBA Inferred from Biological aspect of Ancestor more info
involved_in tolerance induction to self antigen	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in toll-like receptor 4 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info
is_active_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
part_of integrin alpha2-beta1 complex	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in mitochondrial crista	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic specialization, intracellular component	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: tyrosine-protein kinase Lyn

Names: V-yes-1 Yamaguchi sarcoma viral related oncogene homolog; Yamaguchi sarcoma viral (v-yes-1) oncogene homolog

NP_001104566.1

EC 2.7.10.2

NP_034877.2

EC 2.7.10.2

XP_036019675.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001111096.2 → NP_001104566.1 tyrosine-protein kinase Lyn isoform A

See identical proteins and their annotated locations for NP_001104566.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (A).

Source sequence(s)

AL772401

Consensus CDS

CCDS51109.1

UniProtKB/Swiss-Prot

P25911, Q62127

UniProtKB/TrEMBL

Q3TCS3, Q8CEI0

Related

ENSMUSP00000038838.7, ENSMUST00000041377.13

Conserved Domains (4) summary

cd10364
Location:125 → 225

SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn

cd12004
Location:67 → 122

SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase

cd05072
Location:239 → 510

PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn

pfam07714
Location:247 → 497

Pkinase_Tyr; Protein tyrosine kinase
NM_010747.3 → NP_034877.2 tyrosine-protein kinase Lyn isoform B

See identical proteins and their annotated locations for NP_034877.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform B).

Source sequence(s)

AL772401

Consensus CDS

CCDS17939.1

UniProtKB/TrEMBL

Q3U6Q5, Q8CEI0

Related

ENSMUSP00000100075.4, ENSMUST00000103010.4

Conserved Domains (4) summary

cd10364
Location:104 → 204

SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn

cd12004
Location:46 → 101

SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase

cd05072
Location:218 → 489

PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn

pfam07714
Location:226 → 476

Pkinase_Tyr; Protein tyrosine kinase

RNA

NR_185264.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL772401

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

3676865..3791613

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036163782.1 → XP_036019675.1 tyrosine-protein kinase Lyn isoform X2

Conserved Domains (3) summary

cd12004
Location:67 → 122

SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase

cl15255
Location:125 → 225

SH2; Src homology 2 (SH2) domain

cl21453
Location:235 → 263

PKc_like; Protein Kinases, catalytic domain