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    Vgll1 vestigial like family member 1 [ Mus musculus (house mouse) ]

    Gene ID: 170828, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Vgll1provided by MGI
    Official Full Name
    vestigial like family member 1provided by MGI
    Primary source
    MGI:MGI:2655768
    See related
    Ensembl:ENSMUSG00000031131 AllianceGenome:MGI:2655768
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tondu
    Summary
    Enables protein C-terminus binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in adrenal gland. Orthologous to human VGLL1 (vestigial like family member 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in placenta adult (RPKM 2.1), bladder adult (RPKM 0.1) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    Location:
    X A6; X 30.89 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (56133466..56151900)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (57088106..57106540)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene bombesin-like receptor 3 Neighboring gene HIV TAT specific factor 1 Neighboring gene STARR-seq mESC enhancer starr_47211 Neighboring gene predicted gene 14718 Neighboring gene CD40 ligand

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Structural and functional similarity between the Vgll1-TEAD and the YAP-TEAD complexes. Pobbati AV, et al. Structure, 2012 Jul 3. PMID 22632831
    2. Allelic variants between mouse substrains BALB/cJ and BALB/cByJ influence mononuclear cardiomyocyte composition and cardiomyocyte nuclear ploidy. Gan P, et al. Sci Rep, 2020 May 5. PMID 32371981, Free PMC Article
    3. A Sveinsson's chorioretinal atrophy-associated missense mutation in mouse Tead1 affects its interaction with the co-factors YAP and TAZ. Kitagawa M. Biochem Biophys Res Commun, 2007 Oct 5. PMID 17689488
    4. Expression pattern of transcriptional enhanced associate domain family member 1 (Tead1) in developing mouse molar tooth. Niki Y, et al. Gene Expr Patterns, 2021 Jun. PMID 33984529
    5. An estrogen-responsive module in the ventromedial hypothalamus selectively drives sex-specific activity in females. Correa SM, et al. Cell Rep, 2015 Jan 6. PMID 25543145, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Spontaneous (1)  1 citation
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transcription cofactor vestigial-like protein 1
    Names
    vestigial like 1 homolog
    vestigial-related factor
    vgl-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313763.1 → NP_001300692.1  transcription cofactor vestigial-like protein 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
      Source sequence(s)
      AL672128
      Consensus CDS
      CCDS30151.1
      UniProtKB/Swiss-Prot
      A2AFJ9, Q99NC0
      UniProtKB/TrEMBL
      A6H6P3
      Related
      ENSMUSP00000110393.3, ENSMUST00000114745.9
      Conserved Domains (1) summary
      pfam07545
      Location:21 → 51
      Vg_Tdu; Vestigial/Tondu family

    2. NM_133251.2 → NP_573514.1  transcription cofactor vestigial-like protein 1

      See identical proteins and their annotated locations for NP_573514.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
      Source sequence(s)
      AL672128
      Consensus CDS
      CCDS30151.1
      UniProtKB/Swiss-Prot
      A2AFJ9, Q99NC0
      UniProtKB/TrEMBL
      A6H6P3
      Related
      ENSMUSP00000033465.4, ENSMUST00000033465.10
      Conserved Domains (1) summary
      pfam07545
      Location:21 → 51
      Vg_Tdu; Vestigial/Tondu family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      56133466..56151900
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99NC0.1 GenPept UniProtKB/Swiss-Prot:Q99NC0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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