Acbd3 acyl-Coenzyme A binding domain containing 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Acbd3provided by MGI
Official Full Name: acyl-Coenzyme A binding domain containing 3provided by MGI
Primary source: MGI:MGI:2181074
See related: Ensembl:ENSMUSG00000026499 AllianceGenome:MGI:2181074
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pap7; 60kDa; GCP60; GOLPH1; Gocap1; D1Ertd10e; 8430407O11Rik
Summary: Predicted to enable protein kinase A regulatory subunit binding activity. Predicted to act upstream of or within steroid biosynthetic process. Predicted to be located in Golgi apparatus. Predicted to be active in Golgi membrane. Is expressed in brain; genitourinary system; gut; and lung. Orthologous to human ACBD3 (acyl-CoA binding domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in placenta adult (RPKM 17.7), limb E14.5 (RPKM 13.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H4; 1 84.46 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (180553608..180581769)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (180726043..180754204)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A Crucial Role of ACBD3 Required for Coxsackievirus Infection in Animal Model Developed by AAV-Mediated CRISPR Genome Editing Technique.
Title: A Crucial Role of ACBD3 Required for Coxsackievirus Infection in Animal Model Developed by AAV-Mediated CRISPR Genome Editing Technique.
these findings suggest that ACBD3 has prominent impacts on cellular NAD(+) metabolism via regulating PARP1 activation-dependent auto-modification and thus cell metabolism and function.
Title: Acyl-CoA-binding domain containing 3 modulates NAD+ metabolism through activating poly(ADP-ribose) polymerase 1.
Study reports that ACBD3 is a Numb partner in cell-fate specification, ACBD3 and Numb proteins interact through an essential Numb domain, and the respective loss- and gain-of-function mutant mice share phenotypic similarities.
Title: The mammalian Golgi regulates numb signaling in asymmetric cell division by releasing ACBD3 during mitosis.
These results suggest that PBR, in addition to its role in cholesterol and coproporphyrinogen III transport, is also directing the mitochondrial PPIX import, a function that can be ascribed to the 18kDa PBR protein alone
Title: Protoporphyrin IX binding and transport by recombinant mouse PBR.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125959 (e-PCR)
- UniSTS:162671

C76375 (e-PCR)
- UniSTS:207261

AI234525 (e-PCR)
- UniSTS:250338

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables fatty-acyl-CoA binding	IEA Inferred from Electronic Annotation more info
enables protein kinase A regulatory subunit binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within steroid biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Golgi resident protein GCP60

Names: PBR associated protein; PBR- and PKA-associated protein 7; acyl-CoA-binding domain-containing protein 3; golgi complex associated protein 1, 60 kDa; golgi complex-associated protein 1; golgi phosphoprotein 1; peripheral benzodiazepine receptor-associated protein PAP7; peripherial benzodiazepine receptor associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.