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    Smco4 single-pass membrane protein with coiled-coil domains 4 [ Mus musculus (house mouse) ]

    Gene ID: 170748, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Smco4provided by MGI
    Official Full Name
    single-pass membrane protein with coiled-coil domains 4provided by MGI
    Primary source
    MGI:MGI:3039636
    See related
    Ensembl:ENSMUSG00000058173 AllianceGenome:MGI:3039636
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fn5
    Summary
    Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human SMCO4 (single-pass membrane protein with coiled-coil domains 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 6.3), lung adult (RPKM 4.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 A2; 9 4.95 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (15379736..15456556)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (15468440..15545260)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit G1 pseudogene Neighboring gene predicted gene, 39294 Neighboring gene spermatogenesis associated 2 pseudogene Neighboring gene predicted gene, 35176 Neighboring gene STARR-positive B cell enhancer ABC_E2281 Neighboring gene predicted gene, 51703 Neighboring gene STARR-seq mESC enhancer starr_23385 Neighboring gene predicted gene, 46152 Neighboring gene deuterosome assembly protein 1 Neighboring gene STARR-seq mESC enhancer starr_23386 Neighboring gene RIKEN cDNA 4930540M03 gene Neighboring gene predicted gene, 39295

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of the Fugu rubripes NLK and FN5 genes flanking the NF1 (Neurofibromatosis type 1) gene in the 5' direction and mapping of the human counterparts. Kehrer-Sawatzki H, et al. Gene, 2000 Jun 13. PMID 10863097
    2. Global gene expression analysis of murine limb development. Taher L, et al. PLoS One, 2011. PMID 22174793, Free PMC Article
    3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    single-pass membrane and coiled-coil domain-containing protein 4
    Names
    UPF0443 protein C11orf75 homolog

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359604.1 → NP_001346533.1  single-pass membrane and coiled-coil domain-containing protein 4

      Status: VALIDATED

      Source sequence(s)
      AC155249, AC155259
      Consensus CDS
      CCDS22838.1
      UniProtKB/Swiss-Prot
      Q8VD32, Q9JIS3
      Related
      ENSMUSP00000150121.2, ENSMUST00000215907.2
      Conserved Domains (1) summary
      pfam15012
      Location:1 → 55
      DUF4519; Domain of unknown function (DUF4519)

    2. NM_133214.2 → NP_573477.2  single-pass membrane and coiled-coil domain-containing protein 4

      See identical proteins and their annotated locations for NP_573477.2

      Status: VALIDATED

      Source sequence(s)
      AF197136, CO800370
      Consensus CDS
      CCDS22838.1
      UniProtKB/Swiss-Prot
      Q8VD32, Q9JIS3
      Related
      ENSMUSP00000044228.4, ENSMUST00000045620.10
      Conserved Domains (1) summary
      pfam15012
      Location:1 → 55
      DUF4519; Domain of unknown function (DUF4519)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      15379736..15456556
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510043.2 → XP_006510106.1  single-pass membrane and coiled-coil domain-containing protein 4 isoform X1

      Conserved Domains (1) summary
      pfam15012
      Location:107 → 161
      DUF4519; Domain of unknown function (DUF4519)

    2. XM_036154632.1 → XP_036010525.1  single-pass membrane and coiled-coil domain-containing protein 4 isoform X2

      UniProtKB/Swiss-Prot
      Q8VD32, Q9JIS3
      Conserved Domains (1) summary
      pfam15012
      Location:1 → 55
      DUF4519; Domain of unknown function (DUF4519)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JIS3.2 GenPept UniProtKB/Swiss-Prot:Q9JIS3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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