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    Xpnpep2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound [ Mus musculus (house mouse) ]

    Gene ID: 170745, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Xpnpep2provided by MGI
    Official Full Name
    X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-boundprovided by MGI
    Primary source
    MGI:MGI:2180001
    See related
    Ensembl:ENSMUSG00000037005 AllianceGenome:MGI:2180001
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mAPP; 9030008G12Rik
    Summary
    Predicted to enable metal ion binding activity and metalloaminopeptidase activity. Predicted to act upstream of or within proteolysis. Predicted to be located in extracellular exosome. Is expressed in brain; forelimb bud; large intestine; and neural retina. Human ortholog(s) of this gene implicated in acquired angioedema. Orthologous to human XPNPEP2 (X-prolyl aminopeptidase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in large intestine adult (RPKM 66.4), small intestine adult (RPKM 32.1) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    X A4; X 25.52 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (47195790..47225859)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (48106913..48136982)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene calmodulin 2 pseudogene Neighboring gene apelin Neighboring gene STARR-seq mESC enhancer starr_47100 Neighboring gene STARR-seq mESC enhancer starr_47102 Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:45490128-45490351 Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:45494812-45494921 Neighboring gene SAM and SH3 domain containing 3 Neighboring gene STARR-seq mESC enhancer starr_47106 Neighboring gene zinc finger, DHHC domain containing 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Rat and mouse membrane aminopeptidase P: structure analysis and tissue distribution. Erşahin C, et al. Arch Biochem Biophys, 2003 Sep 15. PMID 12941294
    2. Wnt signaling specifies and patterns intestinal endoderm. Sherwood RI, et al. Mech Dev, 2011 Sep-Dec. PMID 21854845, Free PMC Article
    3. Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Lewandowski JP, et al. Dev Biol, 2015 Oct 1. PMID 26238476, Free PMC Article
    4. A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Thompson CL, et al. Neuron, 2014 Jul 16. PMID 24952961, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloaminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    xaa-Pro aminopeptidase 2
    Names
    X-prolyl aminopeptidase 2
    membrane-bound APP
    membrane-bound aminopeptidase P
    NP_001276658.1
    NP_573476.2
    XP_006541495.1
    XP_036017721.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289729.1 → NP_001276658.1  xaa-Pro aminopeptidase 2 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).
      Source sequence(s)
      AF428102, AK078835, AK085520, AK164538, AL672274
      Consensus CDS
      CCDS81125.1
      UniProtKB/TrEMBL
      B1AVD2
      Related
      ENSMUSP00000110652.4, ENSMUST00000115000.4
      Conserved Domains (5) summary
      COG0006
      Location:367 → 656
      PepP; Xaa-Pro aminopeptidase [Amino acid transport and metabolism]
      cd01085
      Location:432 → 651
      APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
      pfam01321
      Location:53 → 177
      Creatinase_N; Creatinase/Prolidase N-terminal domain
      pfam16188
      Location:651 → 715
      Peptidase_M24_C; C-terminal region of peptidase_M24
      pfam16189
      Location:202 → 428
      Creatinase_N_2; Creatinase/Prolidase N-terminal domain

    2. NM_133213.2 → NP_573476.2  xaa-Pro aminopeptidase 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_573476.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate splice site in the 3' coding region, compared to variant 2. This results in a shorter protein (isoform 1), compared to isoform 2.
      Source sequence(s)
      AF428102, AK164538, AL672274
      Consensus CDS
      CCDS30106.1
      UniProtKB/Swiss-Prot
      B1AVD1, Q3TA51, Q3TPA9, Q8BVD6, Q91Y31, Q91ZH9
      Related
      ENSMUSP00000076951.5, ENSMUST00000077775.11
      Conserved Domains (4) summary
      cd01085
      Location:365 → 584
      APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
      pfam01321
      Location:54 → 177
      Creatinase_N; Creatinase/Prolidase N-terminal domain
      pfam16188
      Location:584 → 648
      Peptidase_M24_C; C-terminal region of peptidase_M24
      pfam16189
      Location:195 → 361
      Creatinase_N_2; Creatinase/Prolidase N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      47195790..47225859
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006541432.1 → XP_006541495.1  xaa-Pro aminopeptidase 2 isoform X1

      See identical proteins and their annotated locations for XP_006541495.1

      UniProtKB/Swiss-Prot
      B1AVD1, Q3TA51, Q3TPA9, Q8BVD6, Q91Y31, Q91ZH9
      Conserved Domains (4) summary
      cd01085
      Location:365 → 584
      APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
      pfam01321
      Location:54 → 177
      Creatinase_N; Creatinase/Prolidase N-terminal domain
      pfam16188
      Location:584 → 648
      Peptidase_M24_C; C-terminal region of peptidase_M24
      pfam16189
      Location:195 → 361
      Creatinase_N_2; Creatinase/Prolidase N-terminal domain

    2. XM_036161828.1 → XP_036017721.1  xaa-Pro aminopeptidase 2 isoform X2

      UniProtKB/TrEMBL
      Q8BU59
      Related
      ENSMUSP00000110650.2, ENSMUST00000114998.8
      Conserved Domains (3) summary
      cd01085
      Location:365 → 582
      APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
      pfam01321
      Location:54 → 177
      Creatinase_N; Creatinase/Prolidase N-terminal domain
      pfam16189
      Location:195 → 361
      Creatinase_N_2; Creatinase/Prolidase N-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B1AVD1.1 GenPept UniProtKB/Swiss-Prot:B1AVD1

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