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    Pilrb1 paired immunoglobin-like type 2 receptor beta 1 [ Mus musculus (house mouse) ]

    Gene ID: 170741, updated on 8-Feb-2024

    Summary

    Official Symbol
    Pilrb1provided by MGI
    Official Full Name
    paired immunoglobin-like type 2 receptor beta 1provided by MGI
    Primary source
    MGI:MGI:2450532
    See related
    Ensembl:ENSMUSG00000066684 AllianceGenome:MGI:2450532
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fdact; Pilrb; FDFACT
    Summary
    Enables MHC class I protein binding activity. Involved in negative regulation of osteoclast differentiation. Acts upstream of or within myeloid dendritic cell activation. Located in plasma membrane. Orthologous to human PILRA (paired immunoglobin like type 2 receptor alpha) and PILRB (paired immunoglobin like type 2 receptor beta). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in spleen adult (RPKM 5.4), liver E18 (RPKM 2.8) and 15 other tissues See more
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    Genomic context

    Location:
    5 G2; 5 76.82 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (137850403..137856687, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (137852141..137858425, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E857 Neighboring gene STARR-positive B cell enhancer ABC_E1312 Neighboring gene STARR-positive B cell enhancer ABC_E4798 Neighboring gene methylphosphate capping enzyme Neighboring gene zinc finger, CW type with PWWP domain 1 Neighboring gene STARR-seq mESC enhancer starr_14656 Neighboring gene paired immunoglobin-like type 2 receptor alpha Neighboring gene STARR-seq mESC enhancer starr_14658 Neighboring gene predicted gene, 36551 Neighboring gene paired immunoglobin-like type 2 receptor beta 2 Neighboring gene predicted gene 3103

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MHC class I protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables MHC class I protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    paired immunoglobulin-like type 2 receptor beta
    Names
    activating receptor PILR-beta
    cell surface receptor FDFACT
    immunoglobulin-like cell surface receptor FDFACT, activating counterpart

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133209.2NP_573472.2  paired immunoglobulin-like type 2 receptor beta precursor

      See identical proteins and their annotated locations for NP_573472.2

      Status: VALIDATED

      Source sequence(s)
      AJ400847, BY235581
      Consensus CDS
      CCDS51675.1
      UniProtKB/Swiss-Prot
      Q2YFS2
      UniProtKB/TrEMBL
      B7ZWH4
      Related
      ENSMUSP00000106606.3, ENSMUST00000110978.7
      Conserved Domains (1) summary
      cl11960
      Location:40136
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      137850403..137856687 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240934.3XP_011239236.1  paired immunoglobulin-like type 2 receptor beta isoform X2

      Conserved Domains (1) summary
      cl11960
      Location:2169
      Ig; Immunoglobulin domain
    2. XM_011240933.3XP_011239235.1  paired immunoglobulin-like type 2 receptor beta isoform X1

      Conserved Domains (1) summary
      cl11960
      Location:122218
      Ig; Immunoglobulin domain

    RNA

    1. XR_868610.3 RNA Sequence

    2. XR_377143.4 RNA Sequence