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    Parvb parvin, beta [ Mus musculus (house mouse) ]

    Gene ID: 170736, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Parvbprovided by MGI
    Official Full Name
    parvin, betaprovided by MGI
    Primary source
    MGI:MGI:2153063
    See related
    Ensembl:ENSMUSG00000022438 AllianceGenome:MGI:2153063
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D15Gsk1; affixin
    Summary
    Predicted to enable actin binding activity. Predicted to be involved in several processes, including actin cytoskeleton reorganization; lamellipodium assembly; and substrate adhesion-dependent cell spreading. Predicted to be located in several cellular components, including cell junction; cytoskeleton; and plasma membrane. Predicted to be active in several cellular components, including actin cytoskeleton; focal adhesion; and lamellipodium. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; liver; and sensory organ. Orthologous to human PARVB (parvin beta). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in heart adult (RPKM 18.6), lung adult (RPKM 17.3) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Parvb in Genome Data Viewer
    Location:
    15 E2; 15 39.78 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (84116244..84199890)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (84232043..84315689)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene patatin-like phospholipase domain containing 3 Neighboring gene STARR-seq mESC enhancer starr_39354 Neighboring gene gamma-secretase subunit PEN-2 pseudogene Neighboring gene SAMM50 sorting and assembly machinery component Neighboring gene VISTA enhancer mm91 Neighboring gene STARR-seq mESC enhancer starr_39355 Neighboring gene STARR-seq mESC enhancer starr_39356 Neighboring gene predicted gene, 33723 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:84146147-84146300 Neighboring gene predicted gene, 22890 Neighboring gene parvin, gamma

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. An integrin-linked machinery of cytoskeletal regulation that enables experimental tumor initiation and metastatic colonization. Shibue T, et al. Cancer Cell, 2013 Oct 14. PMID 24035453, Free PMC Article
    2. Novel protein-protein interactions inferred from literature context. van Haagen HH, et al. PLoS One, 2009 Nov 18. PMID 19924298, Free PMC Article
    3. SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function. Krüger M, et al. Cell, 2008 Jul 25. PMID 18662549
    4. Dysferlin interacts with affixin (beta-parvin) at the sarcolemma. Matsuda C, et al. J Neuropathol Exp Neurol, 2005 Apr. PMID 15835269
    5. The focal adhesion protein β-parvin controls cardiomyocyte shape and sarcomere assembly in response to mechanical load. Thievessen I, et al. Curr Biol, 2022 Jul 25. PMID 35688156

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Parvins are critical for the organization of endothelial cell-cell junctions, the establishment of endothelial apical-basal polarity, and the integrity of the basement membrane.
      Title: Parvins Are Required for Endothelial Cell-Cell Junctions and Cell Polarity During Embryonic Blood Vessel Formation.
    2. Data from functional molecular imaging demonstrated that beta-parvin plays a regulatory role in the ILK-mediated Akt (also called protein kinase B) signaling cascades, suggesting that beta-parvin might be a crucial modulator of cell survival.
      Title: Functional molecular imaging of ILK-mediated Akt/PKB signaling cascades and the associated role of beta-parvin.
    3. Data show that affixin is a dysferlin binding protein that colocalizes with dysferlin at the sarcolemma of normal skeletal muscle.
      Title: Dysferlin interacts with affixin (beta-parvin) at the sarcolemma.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell projection assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment or maintenance of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment or maintenance of cell polarity regulating cell shape ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lamellipodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in substrate adhesion-dependent cell spreading IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lamellipodium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    beta-parvin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133167.3 → NP_573395.1  beta-parvin

      See identical proteins and their annotated locations for NP_573395.1

      Status: VALIDATED

      Source sequence(s)
      AK147758, AL626769
      Consensus CDS
      CCDS37167.1
      UniProtKB/Swiss-Prot
      Q9ES46
      UniProtKB/TrEMBL
      Q3UGT9
      Related
      ENSMUSP00000023072.7, ENSMUST00000023072.7
      Conserved Domains (1) summary
      pfam00307
      Location:89 → 190
      CH; Calponin homology (CH) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      84116244..84199890
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520532.4 → XP_006520595.2  beta-parvin isoform X1

      Conserved Domains (1) summary
      pfam00307
      Location:51 → 158
      CH; Calponin homology (CH) domain

    2. XM_030248364.1 → XP_030104224.1  beta-parvin isoform X2

      Conserved Domains (1) summary
      pfam00307
      Location:36 → 143
      CH; Calponin homology (CH) domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ES46.1 GenPept UniProtKB/Swiss-Prot:Q9ES46

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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