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    Trhr2 thyrotropin releasing hormone receptor 2 [ Mus musculus (house mouse) ]

    Gene ID: 170732, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Trhr2provided by MGI
    Official Full Name
    thyrotropin releasing hormone receptor 2provided by MGI
    Primary source
    MGI:MGI:2177284
    See related
    Ensembl:ENSMUSG00000039079 AllianceGenome:MGI:2177284
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TRH-R2
    Summary
    Predicted to enable thyrotropin-releasing hormone receptor activity. Acts upstream of or within phospholipase C-activating G protein-coupled receptor signaling pathway. Predicted to be located in neuronal cell body. Predicted to be integral component of plasma membrane. Is expressed in brain; cap mesenchyme; embryo; and female associated reproductive structure. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cortex adult (RPKM 1.2), frontal lobe adult (RPKM 1.1) and 7 other tissues See more
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    Genomic context

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    Location:
    8 E1; 8 70.95 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (123082804..123089725, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (122356065..122363294, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene Zfpm1R1 and Zfpm1R2 erythroid cis-regulatory modules Neighboring gene STARR-positive B cell enhancer ABC_E2277 Neighboring gene predicted gene, 39269 Neighboring gene STARR-positive B cell enhancer ABC_E6696 Neighboring gene Zfpm1R7 and Zfpm1R21 erythroid cis-regulatory modules Neighboring gene zinc finger protein, multitype 1 Neighboring gene Zfpm1R6 erythroid cis-regulatory module Neighboring gene Zfpm1R13 and Zfpm1R24 erythroid cis-regulatory modules Neighboring gene Zfpm1R18 erythroid cis-regulatory module Neighboring gene STARR-seq mESC enhancer starr_22945 Neighboring gene Zfpm1R19 and Zfpm1R14 erythroid cis-regulatory modules Neighboring gene Zfpm1R10 erythroid cis-regulatory module Neighboring gene Zfpm1R12 erythroid cis-regulatory module Neighboring gene predicted gene, 46056 Neighboring gene STARR-positive B cell enhancer ABC_E6697 Neighboring gene STARR-positive B cell enhancer ABC_E6698 Neighboring gene zinc finger CCCH-type containing 18 Neighboring gene interleukin 17C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TRH-receptor-type-2-deficient mice are euthyroid and exhibit increased depression and reduced anxiety phenotypes. Sun Y, et al. Neuropsychopharmacology, 2009 May. PMID 19078951, Free PMC Article
    2. Persistent signaling by thyrotropin-releasing hormone receptors correlates with G-protein and receptor levels. Boutin A, et al. FASEB J, 2012 Aug. PMID 22593547, Free PMC Article
    3. Thyrotropin-releasing hormone receptor type 1 (TRH-R1), not TRH-R2, primarily mediates taltirelin actions in the CNS of mice. Thirunarayanan N, et al. Neuropsychopharmacology, 2013 May. PMID 23303050, Free PMC Article
    4. Regulator of G protein signaling 4 suppresses basal and thyrotropin releasing-hormone (TRH)-stimulated signaling by two mouse TRH receptors, TRH-R(1) and TRH-R(2). Harder S, et al. Endocrinology, 2001 Mar. PMID 11181534
    5. Dynamic expression of thyrotropin-releasing hormone in the mouse definitive endoderm. McKnight KD, et al. Dev Dyn, 2007 Oct. PMID 17849455

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TRH-R2 does not mediate the central nervous system effects of taltirelin, but TRH-R1 does.
      Title: Thyrotropin-releasing hormone receptor type 1 (TRH-R1), not TRH-R2, primarily mediates taltirelin actions in the CNS of mice.
    2. We suggest that persistent signaling by TRHRs is exhibited when sufficient levels of agonist/receptor/G-protein complexes are established and maintained and that TRH-R2 forms and maintains these complexes more efficiently than TRH-R1.
      Title: Persistent signaling by thyrotropin-releasing hormone receptors correlates with G-protein and receptor levels.
    3. data provide the first evidence for the involvement of the TRH/TRH-R system, specifically extrahypothalamic TRH/TRH-R2, in regulating mood and affect
      Title: TRH-receptor-type-2-deficient mice are euthyroid and exhibit increased depression and reduced anxiety phenotypes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables thyrotropin-releasing hormone receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thyrotropin-releasing hormone receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phospholipase C-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    thyrotropin releasing hormone receptor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133202.4 → NP_573465.1  thyrotropin releasing hormone receptor 2

      See identical proteins and their annotated locations for NP_573465.1

      Status: VALIDATED

      Source sequence(s)
      AL591003
      Consensus CDS
      CCDS22734.1
      UniProtKB/TrEMBL
      Q9ERT2
      Conserved Domains (1) summary
      cd14995
      Location:33 → 319
      7tmA_TRH-R; thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      123082804..123089725 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243315.2 → XP_030099175.1  thyrotropin releasing hormone receptor 2 isoform X2

      UniProtKB/TrEMBL
      Q9ERT1
      Conserved Domains (2) summary
      cd14964
      Location:57 → 82
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:33 → 215
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. XM_030243314.1 → XP_030099174.1  thyrotropin releasing hormone receptor 2 isoform X1

      UniProtKB/TrEMBL
      Q9ERT2
      Related
      ENSMUSP00000042575.2, ENSMUST00000044123.2
      Conserved Domains (1) summary
      cd14995
      Location:33 → 319
      7tmA_TRH-R; thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein Strain
    Heading Accession and Version

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