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    Nxf7 nuclear RNA export factor 7 [ Mus musculus (house mouse) ]

    Gene ID: 170722, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Nxf7provided by MGI
    Official Full Name
    nuclear RNA export factor 7provided by MGI
    Primary source
    MGI:MGI:2159343
    See related
    Ensembl:ENSMUSG00000031410 AllianceGenome:MGI:2159343
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nx7; Nxf6; nxf-a; nfx-a1; nxf-a2
    Summary
    Enables mRNA binding activity. Predicted to be involved in poly(A)+ mRNA export from nucleus. Located in cytoplasm. Is expressed in brain; central nervous system ganglion; extraembryonic component; retina; and testis. Orthologous to human NXF2B (nuclear RNA export factor 2B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward placenta adult (RPKM 40.5) See more
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    Genomic context

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    Location:
    X F1; X 57.25 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (134480304..134499530, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (135579555..135598781, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 22233 Neighboring gene preferentially expressed antigen in melanoma-like 3 pseudogene Neighboring gene PRAME like, X-linked 1 Neighboring gene NSA2 ribosome biogenesis homolog pseudogene Neighboring gene t-complex 11 family, X-linked 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Nxf7 deficiency impairs social exploration and spatio-cognitive abilities as well as hippocampal synaptic plasticity in mice. Callaerts-Vegh Z, et al. Front Behav Neurosci, 2015. PMID 26217206, Free PMC Article
    2. Nuclear RNA export factor 7 is localized in processing bodies and neuronal RNA granules through interactions with shuttling hnRNPs. Katahira J, et al. Nucleic Acids Res, 2008 Feb. PMID 18063567, Free PMC Article
    3. Unique X-linked familial FSGS with co-segregating heart block disorder is associated with a mutation in the NXF5 gene. Esposito T, et al. Hum Mol Genet, 2013 Sep 15. PMID 23686279
    4. Identification and characterization of the mouse nuclear export factor (Nxf) family members. Tan W, et al. Nucleic Acids Res, 2005. PMID 16027110, Free PMC Article
    5. Generation and characterization of an Nxf7 knockout mouse to study NXF5 deficiency in a patient with intellectual disability. Vanmarsenille L, et al. PLoS One, 2013. PMID 23675524, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results suggest that NXF7 plays a role in sorting, transport and/or storage of mRNAs through interactions with hnRNP A3.
      Title: Nuclear RNA export factor 7 is localized in processing bodies and neuronal RNA granules through interactions with shuttling hnRNPs.
    2. NXF7 colocalizes with Staufen1, polyA, and 28 S RNA within mobile cytoplasmic granules in neurites and in extended cytoplasmic processes of non-neuronal cells
      Title: Nuclear export factor family protein participates in cytoplasmic mRNA trafficking.
    3. NXF7 localizes exclusively to cytoplasmic granules and lacks mRNA export activity.
      Title: Identification and characterization of the mouse nuclear export factor (Nxf) family members.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in poly(A)+ mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear RNA export factor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    nuclear RNA export factor 7
    Names
    nuclear RNA export factor 6
    nuclear export factor a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001379677.1 → NP_001366606.1  nuclear RNA export factor 7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL671911
      UniProtKB/TrEMBL
      Q99JG5
      Conserved Domains (6) summary
      smart00804
      Location:548 → 609
      TAP_C; C-terminal domain of vertebrate Tap protein
      sd00035
      Location:217 → 259
      LRR_NTF; leucine-rich repeat [structural motif]
      pfam09162
      Location:110 → 191
      Tap-RNA_bind; Tap, RNA-binding
      pfam13855
      Location:258 → 320
      LRR_8; Leucine rich repeat
      cd21340
      Location:224 → 364
      PPP1R42; protein phosphatase 1 regulatory subunit 42
      cl09109
      Location:383 → 529
      NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...

    2. NM_130888.2 → NP_570958.1  nuclear RNA export factor 7 isoform 1

      See identical proteins and their annotated locations for NP_570958.1

      Status: VALIDATED

      Source sequence(s)
      AL671911
      Consensus CDS
      CCDS30406.1
      UniProtKB/TrEMBL
      Q80SZ6, Q99JG5
      Related
      ENSMUSP00000108788.2, ENSMUST00000113163.8
      Conserved Domains (5) summary
      smart00804
      Location:558 → 619
      TAP_C; C-terminal domain of vertebrate Tap protein
      sd00035
      Location:227 → 269
      LRR_NTF; leucine-rich repeat [structural motif]
      pfam13855
      Location:269 → 330
      LRR_8; Leucine rich repeat
      pfam09162
      Location:119 → 201
      Tap-RNA_bind; Tap, RNA-binding
      cl09109
      Location:393 → 539
      NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      134480304..134499530 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006528509.3 → XP_006528572.1  nuclear RNA export factor 7 isoform X1

      See identical proteins and their annotated locations for XP_006528572.1

      UniProtKB/TrEMBL
      Q80SZ6, Q99JG5
      Conserved Domains (5) summary
      smart00804
      Location:558 → 619
      TAP_C; C-terminal domain of vertebrate Tap protein
      sd00035
      Location:227 → 269
      LRR_NTF; leucine-rich repeat [structural motif]
      pfam13855
      Location:269 → 330
      LRR_8; Leucine rich repeat
      pfam09162
      Location:119 → 201
      Tap-RNA_bind; Tap, RNA-binding
      cl09109
      Location:393 → 539
      NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...

    2. XM_006528511.4 → XP_006528574.1  nuclear RNA export factor 7 isoform X2

      See identical proteins and their annotated locations for XP_006528574.1

      UniProtKB/TrEMBL
      Q99JG5
      Conserved Domains (6) summary
      smart00804
      Location:548 → 609
      TAP_C; C-terminal domain of vertebrate Tap protein
      sd00035
      Location:217 → 259
      LRR_NTF; leucine-rich repeat [structural motif]
      pfam09162
      Location:110 → 191
      Tap-RNA_bind; Tap, RNA-binding
      pfam13855
      Location:258 → 320
      LRR_8; Leucine rich repeat
      cd21340
      Location:224 → 364
      PPP1R42; protein phosphatase 1 regulatory subunit 42
      cl09109
      Location:383 → 529
      NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...
    Nucleotide Protein Strain
    Heading Accession and Version

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