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    Muc13 mucin 13, epithelial transmembrane [ Mus musculus (house mouse) ]

    Gene ID: 17063, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Muc13provided by MGI
    Official Full Name
    mucin 13, epithelial transmembraneprovided by MGI
    Primary source
    MGI:MGI:103190
    See related
    Ensembl:ENSMUSG00000022824 AllianceGenome:MGI:103190
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lrrp; Ly64; NJ-1; 14/A10; 114/A10
    Summary
    Predicted to enable protein homodimerization activity. Predicted to be involved in maintenance of gastrointestinal epithelium. Predicted to be located in apical plasma membrane; cytosol; and extracellular space. Is expressed in midgut. Orthologous to human MUC13 (mucin 13, cell surface associated). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in small intestine adult (RPKM 2761.9), large intestine adult (RPKM 1908.7) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    16 B3; 16 24.21 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (33614407..33640299)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (33794037..33819929)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40700 Neighboring gene solute carrier family 12 (potassium/chloride transporters), member 8 Neighboring gene STARR-seq mESC enhancer starr_40702 Neighboring gene STARR-positive B cell enhancer ABC_E5537 Neighboring gene STARR-seq mESC enhancer starr_40703 Neighboring gene heart development protein with EGF-like domains 1 Neighboring gene STARR-positive B cell enhancer ABC_E11611 Neighboring gene STARR-seq mESC enhancer starr_40709 Neighboring gene predicted gene 15658 Neighboring gene STARR-seq mESC enhancer starr_40710 Neighboring gene STARR-positive B cell enhancer ABC_E5538 Neighboring gene STARR-seq mESC enhancer starr_40715 Neighboring gene STARR-seq mESC enhancer starr_40716 Neighboring gene predicted gene, 34967 Neighboring gene integrin beta 5 Neighboring gene STARR-seq mESC enhancer starr_40719

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. IL-22-Activated MUC13 Impacts on Colonic Barrier Function through JAK1/STAT3, SNAI1/ZEB1 and ROCK2/MAPK Signaling. Breugelmans T, et al. Cells, 2023 Apr 23. PMID 37174625, Free PMC Article
    2. MUC13 protects colorectal cancer cells from death by activating the NF-κB pathway and is a potential therapeutic target. Sheng YH, et al. Oncogene, 2017 Feb 2. PMID 27399336, Free PMC Article
    3. Gastric de novo Muc13 expression and spasmolytic polypeptide-expressing metaplasia during Helicobacter heilmannii infection. Liu C, et al. Infect Immun, 2014 Aug. PMID 24866791, Free PMC Article
    4. The MUC13 cell-surface mucin protects against intestinal inflammation by inhibiting epithelial cell apoptosis. Sheng YH, et al. Gut, 2011 Dec. PMID 21636645
    5. Expression and function of NJ-1 surface antigen in megakaryopoiesis. Tang H, et al. Biochem Biophys Res Commun, 2002 Apr 5. PMID 11922618

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MUC13 Cell Surface Mucin Limits Salmonella Typhimurium Infection by Protecting the Mucosal Epithelial Barrier.
      Title: MUC13 Cell Surface Mucin Limits Salmonella Typhimurium Infection by Protecting the Mucosal Epithelial Barrier.
    2. IL-22-Activated MUC13 Impacts on Colonic Barrier Function through JAK1/STAT3, SNAI1/ZEB1 and ROCK2/MAPK Signaling.
      Title: IL-22-Activated MUC13 Impacts on Colonic Barrier Function through JAK1/STAT3, SNAI1/ZEB1 and ROCK2/MAPK Signaling.
    3. High MUC13 expression is associated with colitis-associated colorectal tumors.
      Title: MUC13 promotes the development of colitis-associated colorectal tumors via β-catenin activity.
    4. these data indicate that combining chemotherapy and MUC13 antagonism could improve the treatment of metastatic cancers
      Title: MUC13 protects colorectal cancer cells from death by activating the NF-κB pathway and is a potential therapeutic target.
    5. Muc13 was upregulated in the fundus of the stomach already 1 day after infection with Helicobacter heilmannii.
      Title: Gastric de novo Muc13 expression and spasmolytic polypeptide-expressing metaplasia during Helicobacter heilmannii infection.
    6. these studies demonstrate that MUC1 and MUC13 are important components of gastrointestinal homeostasis and that disruption or inappropriate expression of these mucins could predispose to infectious and inflammatory disease and inflammation-induced cancer.
      Title: MUC1 and MUC13 differentially regulate epithelial inflammation in response to inflammatory and infectious stimuli.
    7. protective role in the colonic epithelium by inhibiting toxin-induced apoptosis
      Title: The MUC13 cell-surface mucin protects against intestinal inflammation by inhibiting epithelial cell apoptosis.
    8. hypothesize that NJ-1(+)megakaryocytes (MKs) are immature MKs and the NJ-1 molecule is involved in MK adhesion to endothelial cells [NJ-1]
      Title: Expression and function of NJ-1 surface antigen in megakaryopoiesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in maintenance of gastrointestinal epithelium ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mucin-13
    Names
    MUC-13
    cell surface antigen 114/A10
    lymphocyte antigen 64

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001382834.1 → NP_001369763.1  mucin-13 precursor

      Status: VALIDATED

      Source sequence(s)
      AC155268, AK132274
      UniProtKB/Swiss-Prot
      P19467
      UniProtKB/TrEMBL
      Q3V1S6
      Related
      ENSMUSP00000023520.7, ENSMUST00000023520.7
      Conserved Domains (1) summary
      smart00200
      Location:274 → 391
      SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

    2. NM_010739.2 → NP_034869.1  mucin-13 precursor

      See identical proteins and their annotated locations for NP_034869.1

      Status: VALIDATED

      Source sequence(s)
      BY441725, J04634
      Consensus CDS
      CCDS28134.1
      UniProtKB/Swiss-Prot
      P19467
      UniProtKB/TrEMBL
      Q3V1S6
      Related
      ENSMUSP00000110696.2, ENSMUST00000115044.8
      Conserved Domains (1) summary
      smart00200
      Location:274 → 391
      SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      33614407..33640299
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521815.3 → XP_006521878.1  mucin-13 isoform X1

      Conserved Domains (1) summary
      smart00200
      Location:247 → 364
      SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P19467.1 GenPept UniProtKB/Swiss-Prot:P19467

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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