U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Stard4 StAR related lipid transfer domain containing 4 [ Mus musculus (house mouse) ]

    Gene ID: 170459, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Stard4provided by MGI
    Official Full Name
    StAR related lipid transfer domain containing 4provided by MGI
    Primary source
    MGI:MGI:2156764
    See related
    Ensembl:ENSMUSG00000024378 AllianceGenome:MGI:2156764
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4632419C16Rik; 9030213J02Rik
    Summary
    Predicted to enable cholesterol binding activity and cholesterol transfer activity. Involved in cholesterol esterification. Located in cytosol and endoplasmic reticulum. Is expressed in gut and urinary system. Orthologous to human STARD4 (StAR related lipid transfer domain containing 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 12.6), large intestine adult (RPKM 11.2) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    18 B1; 18 18.18 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (33332191..33346937, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (33199138..33213862, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2310026I22 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:33100529-33100712 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:33105060-33105243 Neighboring gene STARR-seq mESC enhancer starr_44161 Neighboring gene calcium/calmodulin-dependent protein kinase IV Neighboring gene STARR-seq mESC enhancer starr_44162 Neighboring gene STARR-seq mESC enhancer starr_44163 Neighboring gene STARR-seq mESC enhancer starr_44164 Neighboring gene STARR-seq mESC enhancer starr_44165 Neighboring gene predicted gene, 54015 Neighboring gene STARR-positive B cell enhancer ABC_E775 Neighboring gene predicted gene, 41683 Neighboring gene VISTA enhancer mm76 Neighboring gene predicted gene, 46640 Neighboring gene O-sialoglycoprotein endopeptidase pseudogene

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. STARD4 Membrane Interactions and Sterol Binding. Iaea DB, et al. Biochemistry, 2015 Aug 4. PMID 26168008, Free PMC Article
    2. Targeted disruption of steroidogenic acute regulatory protein D4 leads to modest weight reduction and minor alterations in lipid metabolism. Riegelhaupt JJ, et al. J Lipid Res, 2010 May. PMID 19965609, Free PMC Article
    3. Subcellular localization and regulation of StarD4 protein in macrophages and fibroblasts. Rodriguez-Agudo D, et al. Biochim Biophys Acta, 2011 Oct. PMID 21767660, Free PMC Article
    4. Differential gene regulation of StarD4 and StarD5 cholesterol transfer proteins. Activation of StarD4 by sterol regulatory element-binding protein-2 and StarD5 by endoplasmic reticulum stress. Soccio RE, et al. J Biol Chem, 2005 May 13. PMID 15760897
    5. Intracellular cholesterol transporter StarD4 binds free cholesterol and increases cholesteryl ester formation. Rodriguez-Agudo D, et al. J Lipid Res, 2008 Jul. PMID 18403318, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. a model of STARD4 membrane interaction and sterol binding and release that requires dynamic movement of both the Omega1 loop and membrane insertion of the C-terminal alpha-helix.
      Title: STARD4 Membrane Interactions and Sterol Binding.
    2. StARD4's role can largely be compensated for by other intracellular cholesterol transporters.
      Title: Targeted disruption of steroidogenic acute regulatory protein D4 leads to modest weight reduction and minor alterations in lipid metabolism.
    3. StarD4 plays an important role as a directional cholesterol transporter in the maintenance of cellular cholesterol homeostasis
      Title: Intracellular cholesterol transporter StarD4 binds free cholesterol and increases cholesteryl ester formation.
    4. StarD4 is regulated by sterols via SREBP-2, and StarD5 is activated by ER stress cholesterol metabolism; they serve different functions
      Title: Differential gene regulation of StarD4 and StarD5 cholesterol transfer proteins. Activation of StarD4 by sterol regulatory element-binding protein-2 and StarD5 by endoplasmic reticulum stress.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (2) 

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cholesterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cholesterol binding ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables cholesterol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cholesterol transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cholesterol transfer activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cholesterol import IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cholesterol import ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cholesterol transport involved in cholesterol storage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cholesterol transport involved in cholesterol storage ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular cholesterol transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of bile acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    stAR-related lipid transfer protein 4
    Names
    START domain-containing protein 4
    StAR-related lipid transfer (START) domain containing 4

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347624.1 → NP_001334553.1  stAR-related lipid transfer protein 4 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon and contains an alternate exon, resulting in a frameshift compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC114919
      Consensus CDS
      CCDS84369.1
      UniProtKB/TrEMBL
      D3YW30
      Related
      ENSMUSP00000114109.2, ENSMUST00000119991.8

    2. NM_133774.5 → NP_598535.1  stAR-related lipid transfer protein 4 isoform 1

      See identical proteins and their annotated locations for NP_598535.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC114919, AK085331, BB850053
      Consensus CDS
      CCDS29123.1
      UniProtKB/Swiss-Prot
      Q99JV5
      UniProtKB/TrEMBL
      Q80SX0
      Related
      ENSMUSP00000025236.3, ENSMUST00000025236.9
      Conserved Domains (1) summary
      cd08902
      Location:21 → 222
      START_STARD4-like; Lipid-binding START domain of mammalian STARD4 and related proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      33332191..33346937 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161001.1 → XP_036016894.1  stAR-related lipid transfer protein 4 isoform X1

      UniProtKB/TrEMBL
      D3YW24
      Related
      ENSMUSP00000114131.2, ENSMUST00000118990.2
      Conserved Domains (1) summary
      cl14643
      Location:21 → 110
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_180986.1: Suppressed sequence

      Description
      NM_180986.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99JV5.1 GenPept UniProtKB/Swiss-Prot:Q99JV5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous