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    Lrrn3 leucine rich repeat protein 3, neuronal [ Mus musculus (house mouse) ]

    Gene ID: 16981, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Lrrn3provided by MGI
    Official Full Name
    leucine rich repeat protein 3, neuronalprovided by MGI
    Primary source
    MGI:MGI:106036
    See related
    Ensembl:ENSMUSG00000036295 AllianceGenome:MGI:106036
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NLRR-3
    Summary
    Acts upstream of or within positive regulation of synapse assembly. Predicted to be located in plasma membrane. Predicted to be part of clathrin adaptor complex. Predicted to be active in extracellular matrix and extracellular space. Is expressed in several structures, including alimentary system; central nervous system; peripheral nervous system ganglion; respiratory system; and sensory organ. Orthologous to human LRRN3 (leucine rich repeat neuronal 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E18 (RPKM 20.4), whole brain E14.5 (RPKM 13.9) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 B1; 12 18.94 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (41501667..41536056, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (41451668..41486057, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) Neighboring gene STARR-seq mESC enhancer starr_31983 Neighboring gene STARR-seq mESC enhancer starr_31984 Neighboring gene predicted gene, 51974 Neighboring gene STARR-seq mESC enhancer starr_31985 Neighboring gene STARR-seq mESC enhancer starr_31987 Neighboring gene STARR-seq mESC enhancer starr_31989 Neighboring gene predicted gene, 25497 Neighboring gene STARR-seq mESC enhancer starr_31990 Neighboring gene STARR-seq mESC enhancer starr_31991 Neighboring gene predicted gene, 40412 Neighboring gene STARR-seq mESC enhancer starr_31992 Neighboring gene STARR-seq mESC enhancer starr_31994 Neighboring gene STARR-seq mESC enhancer starr_31995 Neighboring gene STARR-seq mESC enhancer starr_31996 Neighboring gene STARR-seq mESC enhancer starr_31997 Neighboring gene predicted gene, 46348

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning and expression of a novel gene for a protein with leucine-rich repeats in the developing mouse nervous system. Taniguchi H, et al. Brain Res Mol Brain Res, 1996 Feb. PMID 9011764
    2. Rat neuronal leucine-rich repeat protein-3: cloning and regulation of the gene expression. Fukamachi K, et al. Biochem Biophys Res Commun, 2001 Sep 14. PMID 11549284
    3. Slitrk6 expression profile in the mouse embryo and its relationship to that of Nlrr3. Aruga J. Gene Expr Patterns, 2003 Dec. PMID 14643680
    4. The NLRR gene family and mouse development: Modified differential display PCR identifies NLRR-1 as a gene expressed in early somitic myoblasts. Haines BP, et al. Dev Biol, 2005 May 15. PMID 15893969
    5. Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo. Homma S, et al. Gene Expr Patterns, 2009 Jan. PMID 18848646

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Analysis of NLRR-3 expression revealed regulated expression in the neural system in developing ganglia and motor neurons.
      Title: The NLRR gene family and mouse development: Modified differential display PCR identifies NLRR-1 as a gene expressed in early somitic myoblasts.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of synapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of clathrin adaptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat neuronal protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271708.1 → NP_001258637.1  leucine-rich repeat neuronal protein 3 precursor

      See identical proteins and their annotated locations for NP_001258637.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC167364, BC069041, CJ058856
      Consensus CDS
      CCDS25896.1
      UniProtKB/Swiss-Prot
      P97860, Q8CBC6
      Conserved Domains (8) summary
      smart00370
      Location:139 → 160
      LRR; Leucine-rich repeats, outliers
      smart00013
      Location:28 → 72
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:368 → 419
      LRRCT; Leucine rich repeat C-terminal domain
      pfam07679
      Location:429 → 513
      I-set; Immunoglobulin I-set domain
      sd00033
      Location:94 → 117
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00041
      Location:526 → 593
      fn3; Fibronectin type III domain
      pfam13855
      Location:93 → 152
      LRR_8; Leucine rich repeat
      cl11960
      Location:440 → 513
      Ig; Immunoglobulin domain

    2. NM_001271709.1 → NP_001258638.1  leucine-rich repeat neuronal protein 3 precursor

      See identical proteins and their annotated locations for NP_001258638.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC167364, BC069041, CJ061095
      Consensus CDS
      CCDS25896.1
      UniProtKB/Swiss-Prot
      P97860, Q8CBC6
      Conserved Domains (8) summary
      smart00370
      Location:139 → 160
      LRR; Leucine-rich repeats, outliers
      smart00013
      Location:28 → 72
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:368 → 419
      LRRCT; Leucine rich repeat C-terminal domain
      pfam07679
      Location:429 → 513
      I-set; Immunoglobulin I-set domain
      sd00033
      Location:94 → 117
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00041
      Location:526 → 593
      fn3; Fibronectin type III domain
      pfam13855
      Location:93 → 152
      LRR_8; Leucine rich repeat
      cl11960
      Location:440 → 513
      Ig; Immunoglobulin domain

    3. NM_010733.3 → NP_034863.1  leucine-rich repeat neuronal protein 3 precursor

      See identical proteins and their annotated locations for NP_034863.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC167364, BC069041
      Consensus CDS
      CCDS25896.1
      UniProtKB/Swiss-Prot
      P97860, Q8CBC6
      Related
      ENSMUSP00000043818.5, ENSMUST00000043884.6
      Conserved Domains (8) summary
      smart00370
      Location:139 → 160
      LRR; Leucine-rich repeats, outliers
      smart00013
      Location:28 → 72
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:368 → 419
      LRRCT; Leucine rich repeat C-terminal domain
      pfam07679
      Location:429 → 513
      I-set; Immunoglobulin I-set domain
      sd00033
      Location:94 → 117
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00041
      Location:526 → 593
      fn3; Fibronectin type III domain
      pfam13855
      Location:93 → 152
      LRR_8; Leucine rich repeat
      cl11960
      Location:440 → 513
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      41501667..41536056 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CBC6.1 GenPept UniProtKB/Swiss-Prot:Q8CBC6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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