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    Lrrn2 leucine rich repeat protein 2, neuronal [ Mus musculus (house mouse) ]

    Gene ID: 16980, updated on 5-Mar-2024

    Summary

    Official Symbol
    Lrrn2provided by MGI
    Official Full Name
    leucine rich repeat protein 2, neuronalprovided by MGI
    Primary source
    MGI:MGI:106037
    See related
    Ensembl:ENSMUSG00000026443 AllianceGenome:MGI:106037
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NLRR-2; 5730406J09Rik
    Summary
    Predicted to be active in extracellular matrix and extracellular space. Is expressed in several structures, including adrenal medulla; gut; nervous system; optic cup; and urinary system. Orthologous to human LRRN2 (leucine rich repeat neuronal 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in cerebellum adult (RPKM 20.2), CNS E18 (RPKM 17.7) and 16 other tissues See more
    Orthologs
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    Genomic context

    Location:
    1 E4; 1 57.69 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (132808093..132867743)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (132880355..132940005)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31101 Neighboring gene predicted gene, 22609 Neighboring gene STARR-seq mESC enhancer starr_02263 Neighboring gene STARR-seq mESC enhancer starr_02264 Neighboring gene STARR-seq mESC enhancer starr_02265 Neighboring gene predicted gene, 31159 Neighboring gene predicted gene, 38687 Neighboring gene STARR-seq mESC enhancer starr_02266 Neighboring gene STARR-seq mESC enhancer starr_02269 Neighboring gene transformed mouse 3T3 cell double minute 4 Neighboring gene STARR-seq mESC enhancer starr_02270 Neighboring gene STARR-positive B cell enhancer ABC_E1560 Neighboring gene predicted gene 29257

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (2) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    leucine-rich repeat neuronal protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010732.4NP_034862.1  leucine-rich repeat neuronal protein 2 precursor

      See identical proteins and their annotated locations for NP_034862.1

      Status: VALIDATED

      Source sequence(s)
      AK039216, BB342744, BC056458
      Consensus CDS
      CCDS15289.1
      UniProtKB/TrEMBL
      Q6PHP6, Q6US92
      Related
      ENSMUSP00000027706.4, ENSMUST00000027706.4
      Conserved Domains (7) summary
      cd00116
      Location:62288
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam07679
      Location:430514
      I-set; Immunoglobulin I-set domain
      sd00031
      Location:337360
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:95118
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:117177
      LRR_8; Leucine rich repeat
      cl11960
      Location:438514
      Ig; Immunoglobulin domain
      cl15307
      Location:369412
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      132808093..132867743
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)