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    Lig1 ligase I, DNA, ATP-dependent [ Mus musculus (house mouse) ]

    Gene ID: 16881, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Lig1provided by MGI
    Official Full Name
    ligase I, DNA, ATP-dependentprovided by MGI
    Primary source
    MGI:MGI:101789
    See related
    Ensembl:ENSMUSG00000056394 AllianceGenome:MGI:101789
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LigI
    Summary
    Predicted to enable DNA ligase (ATP) activity. Acts upstream of or within DNA replication; double-strand break repair via nonhomologous end joining; and response to hydrogen peroxide. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in inherited metabolic disorder and primary immunodeficiency disease. Orthologous to human LIG1 (DNA ligase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver E14 (RPKM 34.7), liver E14.5 (RPKM 31.4) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 A1; 7 7.82 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (13011101..13045351)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (13277175..13311426)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene vomeronasal 1 receptor 89 Neighboring gene STARR-seq mESC enhancer starr_18077 Neighboring gene vomeronasal 1 receptor, pseudogene 69 Neighboring gene zinc finger SWIM-type containing 9 Neighboring gene STARR-positive B cell enhancer ABC_E4896 Neighboring gene STARR-seq mESC enhancer starr_18078 Neighboring gene phospholipase A2, group IVC (cytosolic, calcium-independent) Neighboring gene ribosomal protein S8, pseudogene 4 Neighboring gene phospholipase A2, group IVC (cytosolic, calcium-independent), pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. DNA ligase I is not essential for mammalian cell viability. Han L, et al. Cell Rep, 2014 Apr 24. PMID 24726358, Free PMC Article
    2. Replication failure, genome instability, and increased cancer susceptibility in mice with a point mutation in the DNA ligase I gene. Harrison C, et al. Cancer Res, 2002 Jul 15. PMID 12124343
    3. Efficient BLG-Cre mediated gene deletion in the mammary gland. Selbert S, et al. Transgenic Res, 1998 Sep. PMID 9859227
    4. Cloning and sequence analysis of a cDNA coding for the murine DNA ligase I enzyme. Savini E, et al. Gene, 1994 Jul 8. PMID 8039710
    5. Comparison between cDNA clones encoding murine DNA ligase I. Jessop JK, et al. Gene, 1995 Jul 28. PMID 7642116

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Unchanged PCNA and DNMT1 dynamics during replication in DNA ligase I-deficient cells but abnormal chromatin levels of non-replicative histone H1.
      Title: Unchanged PCNA and DNMT1 dynamics during replication in DNA ligase I-deficient cells but abnormal chromatin levels of non-replicative histone H1.
    2. Increased presynaptic glutamate release is a key early event resulting from Lgi1-deficiency, which likely contributes to epileptogenesis.
      Title: LGI1 acts presynaptically to regulate excitatory synaptic transmission during early postnatal development.
    3. Lig1 is not absolutely required for cellular DNA replication and repair in Lig1-null cell line.
      Title: DNA ligase I is not essential for mammalian cell viability.
    4. LigI has a highly specific role in CTG repeat maintenance in the maternal germline, involved in mediating CTG expansions and in the avoidance of maternal CTG contractions.
      Title: Maternal germline-specific effect of DNA ligase I on CTG/CAG instability.
    5. DNA ligase I null mouse cells show normal DNA repair activity but altered DNA replication and reduced genome stability.
      Title: DNA ligase I null mouse cells show normal DNA repair activity but altered DNA replication and reduced genome stability.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA ligase (ATP) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA ligation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT acts_upstream_of_or_within DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in Okazaki fragment processing involved in mitotic DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in base-excision repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within double-strand break repair via nonhomologous end joining IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lagging strand elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to hydrogen peroxide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA ligase 1
    Names
    DNA ligase I
    polydeoxyribonucleotide synthase [ATP] 1
    NP_001076657.2
    NP_001186239.2
    NP_034845.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083188.2 → NP_001076657.2  DNA ligase 1

      Status: VALIDATED

      Source sequence(s)
      AC161792, AK161793, MG954305
      UniProtKB/Swiss-Prot
      P37913
      UniProtKB/TrEMBL
      Q8R055
      Related
      ENSMUSP00000126525.4, ENSMUST00000165964.10
      Conserved Domains (1) summary
      PLN03113
      Location:171 → 912
      PLN03113; DNA ligase 1; Provisional

    2. NM_001199310.2 → NP_001186239.2  DNA ligase 1

      Status: VALIDATED

      Source sequence(s)
      AC161792, AK161793, MG954305
      UniProtKB/Swiss-Prot
      P37913
      UniProtKB/TrEMBL
      Q8R055
      Related
      ENSMUSP00000136972.4, ENSMUST00000177588.10
      Conserved Domains (1) summary
      PLN03113
      Location:171 → 912
      PLN03113; DNA ligase 1; Provisional

    3. NM_010715.3 → NP_034845.3  DNA ligase 1

      Status: VALIDATED

      Source sequence(s)
      AC161792, AK161793, MG954305
      UniProtKB/Swiss-Prot
      P37913
      UniProtKB/TrEMBL
      Q8R055
      Related
      ENSMUSP00000096411.7, ENSMUST00000098814.13
      Conserved Domains (1) summary
      PLN03113
      Location:171 → 912
      PLN03113; DNA ligase 1; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      13011101..13045351
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P37913.2 GenPept UniProtKB/Swiss-Prot:P37913

    Gene LinkOut

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