Lbp lipopolysaccharide binding protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lbpprovided by MGI
Official Full Name: lipopolysaccharide binding proteinprovided by MGI
Primary source: MGI:MGI:1098776
See related: Ensembl:ENSMUSG00000016024 AllianceGenome:MGI:1098776
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ly88; Bpifd2
Summary: Enables lipopolysaccharide binding activity and signaling receptor binding activity. Involved in several processes, including positive regulation of respiratory burst involved in inflammatory response; positive regulation of tumor necrosis factor production; and response to bacterium. Acts upstream of or within several processes, including defense response to Gram-negative bacterium; leukocyte chemotaxis involved in inflammatory response; and positive regulation of neutrophil chemotaxis. Located in cell surface and extracellular space. Is expressed in brain; heart ventricle; liver lobe; and reproductive system. Orthologous to human LBP (lipopolysaccharide binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in subcutaneous fat pad adult (RPKM 102.2), genital fat pad adult (RPKM 70.3) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H1; 2 78.72 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (158148413..158174772)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (158306493..158332852)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gastric cancer-derived LBP promotes liver metastasis by driving intrahepatic fibrotic pre-metastatic niche formation.
Title: Gastric cancer-derived LBP promotes liver metastasis by driving intrahepatic fibrotic pre-metastatic niche formation.
Deficiency of lipopolysaccharide binding protein facilitates adipose browning, glucose uptake and oxygen consumption in mouse embryonic fibroblasts via activating PI3K/Akt/mTOR pathway and inhibiting autophagy.
Title: Deficiency of lipopolysaccharide binding protein facilitates adipose browning, glucose uptake and oxygen consumption in mouse embryonic fibroblasts via activating PI3K/Akt/mTOR pathway and inhibiting autophagy.
Liver lipopolysaccharide binding protein prevents hepatic inflammation in physiological and pathological non-obesogenic conditions.
Title: Liver lipopolysaccharide binding protein prevents hepatic inflammation in physiological and pathological non-obesogenic conditions.
The LBP gene is a macrophage-specific LXR target that promotes foam cell survival and atherogenesis.
Title: The macrophage LBP gene is an LXR target that promotes macrophage survival and atherosclerosis.
LBP is a critical factor in the development of non-alcoholic fatty liver disease.
Title: Loss of lipopolysaccharide-binding protein attenuates the development of diet-induced non-alcoholic fatty liver disease in mice.
LBP is a proinflammatory soluble adipokine that acts as a brake for adipogenesis, strengthening the negative effects of palmitate and LPS on adipocyte differentiation.
Title: Lipopolysaccharide binding protein is an adipokine involved in the resilience of the mouse adipocyte to inflammation.
Differential expression of LBP and TGFB1, along with other genes, in different mesenchymal stromal cells preparations, produces the variable responses to external stimuli.
Title: Divergent levels of LBP and TGFβ1 in murine MSCs lead to heterogenic response to TLR and proinflammatory cytokine activation.
findings describe a novel role for LBP in normal hippocampal development and raise the possibility that some of the behavioral sequelae of early life stress are mediated by reduced expression of LBP during a critical period of neurodevelopment.
Title: Early life stress inhibits expression of a novel innate immune pathway in the developing hippocampus.
The amino acid sequence for two mimic epitopes of the inflammatory site of LBP were determined to be WKAQKRFMKKSG and LKTRKLFWKYKD.
Title: The localization of two mimic epitopes of lipopolysaccharide binding protein and the preparation of their tandem multiple antigen peptide.
Paneth cells express LBP together with other proteins acting in the innate immune response of the gut, such as lysozyme, defensins and intelectin.
Title: Lipopolysaccharide-binding protein: localization in secretory granules of Paneth cells in the mouse small intestine.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (4) 1 citation
Endonuclease-mediated (3)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:224839

Lbp (e-PCR), detects polymorphism
- UniSTS:143759

X99347 (e-PCR)
- UniSTS:163302

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables coreceptor activity	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables lipopeptide binding	ISO Inferred from Sequence Orthology more info
enables lipopolysaccharide binding	IBA Inferred from Biological aspect of Ancestor more info
enables lipopolysaccharide binding	IDA Inferred from Direct Assay more info	PubMed
enables lipopolysaccharide binding	ISO Inferred from Sequence Orthology more info
enables lipoteichoic acid binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in acute-phase response	IBA Inferred from Biological aspect of Ancestor more info
involved_in acute-phase response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface pattern recognition receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to lipoteichoic acid	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-negative bacterium	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-negative bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-positive bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to bacterium	IEA Inferred from Electronic Annotation more info
involved_in detection of molecule of bacterial origin	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within leukocyte chemotaxis involved in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid transport	IEA Inferred from Electronic Annotation more info
involved_in lipopolysaccharide transport	ISO Inferred from Sequence Orthology more info
involved_in lipopolysaccharide-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipopolysaccharide-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in macrophage activation involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in macrophage activation involved in immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in macrophage activation involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
acts_upstream_of neutrophil chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of chemokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of macrophage activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of neutrophil chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phagocytosis, engulfment	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of respiratory burst involved in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of toll-like receptor 4 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane permeability	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
acts_upstream_of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: lipopolysaccharide-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008489.2 → NP_032515.2 lipopolysaccharide-binding protein precursor

See identical proteins and their annotated locations for NP_032515.2

Status: VALIDATED

Source sequence(s)

AA207419, AI643881, AK143562, AL663063, BQ176753

Consensus CDS

CCDS16988.1

UniProtKB/Swiss-Prot

A2AC66, Q61805, Q99KA0

Related

ENSMUSP00000016168.3, ENSMUST00000016168.9

Conserved Domains (2) summary

cd00025
Location:29 → 252

BPI1; BPI/LBP/CETP N-terminal domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) N-terminal domain; binds to and neutralizes lipopolysaccharides from the outer ...

pfam02886
Location:241 → 478

LBP_BPI_CETP_C; LBP / BPI / CETP family, C-terminal domain