Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arhgef2provided by MGI
Official Full Name: Rho/Rac guanine nucleotide exchange factor 2provided by MGI
Primary source: MGI:MGI:103264
See related: Ensembl:ENSMUSG00000028059 AllianceGenome:MGI:103264
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GEF; Lfc; P40; GEFH1; LFP40; Lbcl1; GEF-H1; mKIAA0651
Summary: Enables guanyl-nucleotide exchange factor activity and microtubule binding activity. Involved in several processes, including establishment of mitotic spindle orientation; generation of neurons; and positive regulation of neuron migration. Acts upstream of or within several processes, including actin filament organization; negative regulation of podosome assembly; and regulation of Rho protein signal transduction. Located in several cellular components, including dendritic shaft; podosome; and postsynaptic density. Is expressed in several structures, including brain; dorsal root ganglion; and testis. Used to study neurodevelopmental disorder with midbrain and hindbrain malformations. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with midbrain and hindbrain malformations. Orthologous to human ARHGEF2 (Rho/Rac guanine nucleotide exchange factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 23.5), lung adult (RPKM 11.9) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F1; 3 38.9 cM

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (88500427..88556839)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (88593105..88649532)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CCDC88B interacts with RASAL3 and ARHGEF2 and regulates dendritic cell function in neuroinflammation and colitis.
Title: CCDC88B interacts with RASAL3 and ARHGEF2 and regulates dendritic cell function in neuroinflammation and colitis.
Reducing GEF-H1 Expression Inhibits Renal Cyst Formation, Inflammation, and Fibrosis via RhoA Signaling in Nephronophthisis.
Title: Reducing GEF-H1 Expression Inhibits Renal Cyst Formation, Inflammation, and Fibrosis via RhoA Signaling in Nephronophthisis.
Arhgef2 regulates mitotic spindle orientation in hematopoietic stem cells and is essential for productive hematopoiesis.
Title: Arhgef2 regulates mitotic spindle orientation in hematopoietic stem cells and is essential for productive hematopoiesis.
GEF-H1 Is Required for Colchicine Inhibition of Neutrophil Rolling and Recruitment in Mouse Models of Gout.
Title: GEF-H1 Is Required for Colchicine Inhibition of Neutrophil Rolling and Recruitment in Mouse Models of Gout.
Claudin-2 silencing activates RHOA through the exchange factor GEF-H1.
Title: Claudin-2 suppresses GEF-H1, RHOA, and MRTF, thereby impacting proliferation and profibrotic phenotype of tubular cells.
Here we show that microtubule stabilization, triggered by engagement of the B cell receptor, acts as a cue to release centrosome-associated Exo70, which is redistributed to the immune synapse. This process is coupled to the recruitment and activation of GEF-H1, which is required for assembly of the exocyst complex, used to promote tethering and fusion of lysosomes at the immune synapse.
Title: The exocyst controls lysosome secretion and antigen extraction at the immune synapse of B cells.
GEF-H1 does not contribute significantly to the innate immune sensing of murine norovirus, although its function may be modulated via interaction with the viral NS3 protein.
Title: The Microtubule-Associated Innate Immune Sensor GEF-H1 Does Not Influence Mouse Norovirus Replication in Murine Macrophages.
The GEF-H1-IKKepsilon-IRF5 signaling axis functions independent of NOD-like receptors and is critically required for the recognition of intracellular peptidoglycans and host defenses against Listeria monocytogenes.
Title: Microbial recognition by GEF-H1 controls IKKε mediated activation of IRF5.
GEF-H1 was a novel regulator of inflammatory cytokine production and mycobacterial elimination, and may serve as a novel potential target for clinical treatment of tuberculosis.
Title: Guanine nucleotide exchange factor -H1 promotes inflammatory cytokine production and intracellular mycobacterial elimination in macrophages.
Autophagic regulation of RhoA activity was dependent on GEF-H1 which directly bound to p62 and was degraded by autophagy, resulting in low RhoA activity. In contrast, the loss of autophagy increased GEF-H1 levels and thereby activated RhoA, which caused cells to move by amoeba-like migration. This amoeba-like migration was cancelled by the silencing of GEF-H1.
Title: Autophagy suppresses cell migration by degrading GEF-H1, a RhoA GEF.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (4) 1 citation
Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125826 (e-PCR)
- UniSTS:162570

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

RH124802 (e-PCR)
- UniSTS:161624

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within actin filament organization	IPI Inferred from Physical Interaction more info	PubMed
involved_in actin filament organization	ISO Inferred from Sequence Orthology more info
involved_in asymmetric neuroblast division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in asymmetric neuroblast division	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in cell morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell morphogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cellular response to muramyl dipeptide	ISO Inferred from Sequence Orthology more info
involved_in establishment of mitotic spindle orientation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of microtubule depolymerization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of podosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in regulation of Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of Rho protein signal transduction	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in dendritic shaft	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in podosome	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density, intracellular component	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
is_active_in ruffle membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: rho guanine nucleotide exchange factor 2

Names: LBC'S first cousin; guanine nucleotide exchange factor H1; lymphoid blast crisis-like 1; oncogene LFC; rho/rac guanine nucleotide exchange factor (GEF) 2; rhobin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001198911.2 → NP_001185840.1 rho guanine nucleotide exchange factor 2 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) has multiple differences at its 5' end, including a different translation initiation site, compared to variant 1. Variant 2 encodes a shorter protein (isoform 2) with a different N-terminus, compared to isoform 1.

Source sequence(s)

AC145168

Consensus CDS

CCDS57220.1

UniProtKB/TrEMBL

H3BJ45, H3BJU7

Related

ENSMUSP00000134840.2, ENSMUST00000177498.8

Conserved Domains (4) summary

cd00029
Location:25 → 70

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00160
Location:220 → 414

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd13393
Location:454 → 569

PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain

pfam00169
Location:457 → 555

PH; PH domain
NM_001198912.2 → NP_001185841.1 rho guanine nucleotide exchange factor 2 isoform 3

See identical proteins and their annotated locations for NP_001185841.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) has a different 5' UTR and uses a downstream in-frame translation initiation site, compared to variant 1. Variant 3 encodes a shorter protein (isoform 3), compared to isoform 1.

Source sequence(s)

AC145168

Consensus CDS

CCDS57222.1

UniProtKB/TrEMBL

H3BJU7

Related

ENSMUSP00000103134.4, ENSMUST00000107510.10

Conserved Domains (4) summary

cd00029
Location:13 → 58

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00160
Location:210 → 404

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02680
Location:773 → 845

TIGR02680; TIGR02680 family protein

cd13393
Location:444 → 559

PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
NM_001198913.2 → NP_001185842.1 rho guanine nucleotide exchange factor 2 isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) has multiple differences at its 5' end and uses a downstream in-frame translation initiation site, compared to variant 1. Variant 4 encodes a shorter protein (isoform 4), compared to isoform 1.

Source sequence(s)

AC145168

Consensus CDS

CCDS57221.1

UniProtKB/TrEMBL

H3BJU7

Related

ENSMUSP00000127843.3, ENSMUST00000170653.9

Conserved Domains (4) summary

cd00029
Location:13 → 58

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00160
Location:208 → 402

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02680
Location:771 → 843

TIGR02680; TIGR02680 family protein

cd13393
Location:442 → 557

PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
NM_001377126.1 → NP_001364055.1 rho guanine nucleotide exchange factor 2 isoform 5

Status: VALIDATED

Source sequence(s)

AC145168

UniProtKB/TrEMBL

H3BJU7

Conserved Domains (3) summary

cd00160
Location:229 → 423

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd13393
Location:463 → 578

PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain

cd20877
Location:27 → 87

C1_ARHGEF2; protein kinase C conserved region 1 (C1 domain) found in Rho guanine nucleotide exchange factor 2 (ARHGEF2) and similar proteins
NM_001428493.1 → NP_001415422.1 rho guanine nucleotide exchange factor 2 isoform 6

Status: VALIDATED

Source sequence(s)

AC145168

UniProtKB/TrEMBL

H3BJ40
NM_001428494.1 → NP_001415423.1 rho guanine nucleotide exchange factor 2 isoform 7

Status: VALIDATED

Source sequence(s)

AC145168
NM_001428495.1 → NP_001415424.1 rho guanine nucleotide exchange factor 2 isoform 8

Status: VALIDATED

Source sequence(s)

AC145168
NM_001428496.1 → NP_001415425.1 rho guanine nucleotide exchange factor 2 isoform 3

Status: VALIDATED

Source sequence(s)

AC145168
NM_001428497.1 → NP_001415426.1 rho guanine nucleotide exchange factor 2 isoform 4

Status: VALIDATED

Source sequence(s)

AC145168
NM_008487.4 → NP_032513.3 rho guanine nucleotide exchange factor 2 isoform 1

See identical proteins and their annotated locations for NP_032513.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC145168

Consensus CDS

CCDS17481.1

UniProtKB/Swiss-Prot

E9QNW9, O09115, Q3TBI4, Q3TJ16, Q60875, Q8CHE1, Q923E0, Q9ESG7

UniProtKB/TrEMBL

H3BKH9

Related

ENSMUSP00000029694.8, ENSMUST00000029694.14

Conserved Domains (4) summary

cd00029
Location:40 → 85

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00160
Location:237 → 431

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd13393
Location:471 → 586

PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain

pfam00169
Location:474 → 572

PH; PH domain

RNA

NR_190380.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC145168

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

88500427..88556839

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011240027.4 → XP_011238329.1 rho guanine nucleotide exchange factor 2 isoform X4

UniProtKB/TrEMBL

H3BJX8

Conserved Domains (4) summary

cd00029
Location:240 → 285

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00160
Location:437 → 631

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02680
Location:1000 → 1072

TIGR02680; TIGR02680 family protein

cd13393
Location:671 → 786

PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
XM_006501058.4 → XP_006501121.1 rho guanine nucleotide exchange factor 2 isoform X1

UniProtKB/TrEMBL

H3BJX8

Related

ENSMUSP00000135168.3, ENSMUST00000175903.9

Conserved Domains (4) summary

cd00029
Location:240 → 285

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00160
Location:437 → 631

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02680
Location:1000 → 1072

TIGR02680; TIGR02680 family protein

cd13393
Location:671 → 786

PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
XM_006501059.4 → XP_006501122.1 rho guanine nucleotide exchange factor 2 isoform X2

UniProtKB/TrEMBL

H3BJX8

Conserved Domains (4) summary

cd00029
Location:240 → 285

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00160
Location:435 → 629

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02680
Location:998 → 1070

TIGR02680; TIGR02680 family protein

cd13393
Location:669 → 784

PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
XM_006501060.4 → XP_006501123.1 rho guanine nucleotide exchange factor 2 isoform X3

UniProtKB/TrEMBL

H3BJX8

Conserved Domains (4) summary

cd00029
Location:173 → 218

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00160
Location:370 → 564

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02680
Location:933 → 1005

TIGR02680; TIGR02680 family protein

cd13393
Location:604 → 719

PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
XM_006501066.2 → XP_006501129.1 rho guanine nucleotide exchange factor 2 isoform X8

Related

ENSMUSP00000134834.2, ENSMUST00000176500.8

Conserved Domains (4) summary

cd00029
Location:25 → 70

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00160
Location:222 → 416

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02680
Location:785 → 857

TIGR02680; TIGR02680 family protein

cd13393
Location:456 → 571

PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
XM_030252438.2 → XP_030108298.1 rho guanine nucleotide exchange factor 2 isoform X6

Conserved Domains (4) summary

cd00029
Location:40 → 85

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00160
Location:235 → 429

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02680
Location:798 → 870

TIGR02680; TIGR02680 family protein

cd13393
Location:469 → 584

PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
XM_006501067.5 → XP_006501130.1 rho guanine nucleotide exchange factor 2 isoform X9

Conserved Domains (4) summary

cd00029
Location:13 → 58

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00160
Location:210 → 404

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02680
Location:773 → 845

TIGR02680; TIGR02680 family protein

cd13393
Location:444 → 559

PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
XM_030252439.2 → XP_030108299.1 rho guanine nucleotide exchange factor 2 isoform X10

Conserved Domains (4) summary

cd00029
Location:13 → 58

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00160
Location:208 → 402

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02680
Location:771 → 843

TIGR02680; TIGR02680 family protein

cd13393
Location:442 → 557

PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
XM_036162907.1 → XP_036018800.1 rho guanine nucleotide exchange factor 2 isoform X5

UniProtKB/TrEMBL

H3BJU7

Conserved Domains (3) summary

cd00160
Location:239 → 433

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd13393
Location:473 → 588

PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain

cd20877
Location:37 → 97

C1_ARHGEF2; protein kinase C conserved region 1 (C1 domain) found in Rho guanine nucleotide exchange factor 2 (ARHGEF2) and similar proteins
XM_036162908.1 → XP_036018801.1 rho guanine nucleotide exchange factor 2 isoform X11

Conserved Domains (2) summary

cd00160
Location:58 → 252

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd13393
Location:292 → 407

PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
XM_006501065.4 → XP_006501128.1 rho guanine nucleotide exchange factor 2 isoform X7

Conserved Domains (4) summary

cd00029
Location:32 → 77

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00160
Location:227 → 421

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02680
Location:790 → 862

TIGR02680; TIGR02680 family protein

cd13393
Location:461 → 576

PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
XM_036162909.1 → XP_036018802.1 rho guanine nucleotide exchange factor 2 isoform X11

UniProtKB/TrEMBL

H3BJU7

Conserved Domains (2) summary

cd00160
Location:58 → 252

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd13393
Location:292 → 407

PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain