Lamb3 laminin, beta 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lamb3provided by MGI
Official Full Name: laminin, beta 3provided by MGI
Primary source: MGI:MGI:99915
See related: Ensembl:ENSMUSG00000026639 AllianceGenome:MGI:99915
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to be an extracellular matrix structural constituent. Acts upstream of or within brown fat cell differentiation. Located in basement membrane. Part of laminin-5 complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and respiratory system. Used to study junctional epidermolysis bullosa Herlitz type and junctional epidermolysis bullosa non-Herlitz type. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 1A; junctional epidermolysis bullosa; junctional epidermolysis bullosa Herlitz type; junctional epidermolysis bullosa non-Herlitz type; and lung small cell carcinoma. Orthologous to human LAMB3 (laminin subunit beta 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in colon adult (RPKM 41.0), lung adult (RPKM 26.5) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H6; 1 97.71 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (192976661..193026186)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (193294353..193343878)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SOX10 deficiency-mediated LAMB3 upregulation determines the invasiveness of MAPKi-resistant melanoma.
Title: SOX10 deficiency-mediated LAMB3 upregulation determines the invasiveness of MAPKi-resistant melanoma.
Tissue substructure-specific deposition of the beta3-containing laminin-332 in the biliary epithelium of human and mouse livers.
Title: Tissue substructure-specific deposition of the β3-containing laminin-332 in the biliary epithelium of human and mouse livers.
A new mouse model of junctional epidermolysis bullosa has been characterized by the LAMB3 628G>A knockin mouse.
Title: A new mouse model of junctional epidermolysis bullosa: the LAMB3 628G>A knockin mouse.
Data suggest that the proper expression of laminin-332 (Lamb3) and laminin-511 (lama5) may regulate appropriate hair morphogenesis.
Title: Spatial and temporal control of laminin-332 and -511 expressions during hair morphogenesis.
Data show thatincreased mRNA of Lamb3 and Adamts2 and enhanced activities of metalloproteinases MMP1, 2 and 7 in transgenic mice expressing the HLA-DQ8.
Title: A deregulated immune response to gliadin causes a decreased villus height in DQ8 transgenic mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Lamb3 (e-PCR), detects polymorphism
- UniSTS:472859

U43298 (e-PCR)
- UniSTS:125748

Lamb3 (e-PCR), detects polymorphism
- UniSTS:143753

Lamb3 (e-PCR), detects polymorphism
- UniSTS:143754

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables extracellular matrix structural constituent	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in basement membrane assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within brown fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in substrate adhesion-dependent cell spreading	IBA Inferred from Biological aspect of Ancestor more info
involved_in tissue development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basement membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info
part_of laminin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of laminin-5 complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: laminin subunit beta-3

Names: epiligrin subunit bata; kalinin B1 chain; kalinin subunit beta; laminin-5 subunit beta; nicein subunit beta; nicein, 125kD; nicein, 125kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001277928.1 → NP_001264857.1 laminin subunit beta-3 precursor

See identical proteins and their annotated locations for NP_001264857.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC022675

Consensus CDS

CCDS15637.1

UniProtKB/Swiss-Prot

Q61087, Q91V90

Related

ENSMUSP00000123875.2, ENSMUST00000159955.2

Conserved Domains (5) summary

smart00180
Location:478 → 528

EGF_Lam; Laminin-type epidermal growth factor-like domai

cd00055
Location:530 → 579

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

TIGR02168
Location:830 → 1161

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam00053
Location:376 → 425

Laminin_EGF; Laminin EGF domain

cl02806
Location:20 → 248

Laminin_N; Laminin N-terminal (Domain VI)
NM_008484.2 → NP_032510.2 laminin subunit beta-3 precursor

See identical proteins and their annotated locations for NP_032510.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC022675, AK078970, BY098011, BY101470, BY248755, CK023039, CX237661

Consensus CDS

CCDS15637.1

UniProtKB/Swiss-Prot

Q61087, Q91V90

Related

ENSMUSP00000016315.10, ENSMUST00000016315.16

Conserved Domains (5) summary

smart00180
Location:478 → 528

EGF_Lam; Laminin-type epidermal growth factor-like domai

cd00055
Location:530 → 579

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

TIGR02168
Location:830 → 1161

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam00053
Location:376 → 425

Laminin_EGF; Laminin EGF domain

cl02806
Location:20 → 248

Laminin_N; Laminin N-terminal (Domain VI)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

192976661..193026186

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006497233.2 → XP_006497296.1 laminin subunit beta-3 isoform X1

See identical proteins and their annotated locations for XP_006497296.1

UniProtKB/Swiss-Prot

Q61087, Q91V90

Related

ENSMUSP00000142053.2, ENSMUST00000194677.6

Conserved Domains (5) summary

smart00180
Location:478 → 528

EGF_Lam; Laminin-type epidermal growth factor-like domai

cd00055
Location:530 → 579

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

TIGR02168
Location:830 → 1161

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam00053
Location:376 → 425

Laminin_EGF; Laminin EGF domain

cl02806
Location:20 → 248

Laminin_N; Laminin N-terminal (Domain VI)
XM_006497232.1 → XP_006497295.1 laminin subunit beta-3 isoform X1

See identical proteins and their annotated locations for XP_006497295.1

UniProtKB/Swiss-Prot

Q61087, Q91V90

Conserved Domains (5) summary

smart00180
Location:478 → 528

EGF_Lam; Laminin-type epidermal growth factor-like domai

cd00055
Location:530 → 579

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

TIGR02168
Location:830 → 1161

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam00053
Location:376 → 425

Laminin_EGF; Laminin EGF domain

cl02806
Location:20 → 248

Laminin_N; Laminin N-terminal (Domain VI)