Lamb1 laminin B1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lamb1provided by MGI
Official Full Name: laminin B1provided by MGI
Primary source: MGI:MGI:96743
See related: Ensembl:ENSMUSG00000002900 AllianceGenome:MGI:96743
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lamb-1; Lamb1-1; D130003D08Rik
Summary: Enables enzyme binding activity; glycosphingolipid binding activity; and integrin binding activity. Involved in negative regulation of cell adhesion. Acts upstream of or within cell migration; embryo implantation; and neuron projection development. Located in basement membrane; nucleus; and perinuclear region of cytoplasm. Part of laminin-1 complex and laminin-10 complex. Is expressed in several structures, including alimentary system; extraembryonic component; eye; genitourinary system; and nervous system. Human ortholog(s) of this gene implicated in autistic disorder and lissencephaly 5. Orthologous to human LAMB1 (laminin subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in ovary adult (RPKM 32.7), placenta adult (RPKM 32.3) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 A2; 12 13.39 cM

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (31315230..31379643)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (31265146..31329644)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Extracellular matrix protein laminin beta1 regulates pain sensitivity and anxiodepression-like behaviors in mice.
Title: Extracellular matrix protein laminin β1 regulates pain sensitivity and anxiodepression-like behaviors in mice.
Enriched salivary epithelial clusters that were grown in laminin-enriched basement membrane extract or laminin-111 together with exogenous FGF2, but not with EGF, underwent morphogenesis to form organoids that displayed robust expression of AQP5 in terminal buds
Title: FGF2-dependent mesenchyme and laminin-111 are niche factors in salivary gland organoids.
Age-related modulation of laminin beta1 versus beta2 chain expression changes the functional properties and phenotype of endothelial cells. The dysregulation of the extracellular matrix during vascular aging may contribute to age-associated impairment of organ function and fibrosis.
Title: Switch in Laminin β2 to Laminin β1 Isoforms During Aging Controls Endothelial Cell Functions-Brief Report.
Data show that laminin alpha2beta1gamma1 (Lm211) can inhibit neuregulin 1 type III (Nrg1III) by limiting protein kinase A (PKA) activation, which is required to initiate myelination.
Title: Laminin 211 inhibits protein kinase A in Schwann cells to modulate neuregulin 1 type III-driven myelination.
A new mutant mouse (lamb1t) exhibits intermittent dystonic hindlimb movements and postures when awake, and hyperextension when asleep.
Title: A dystonia-like movement disorder with brain and spinal neuronal defects is caused by mutation of the mouse laminin β1 subunit, Lamb1.
This study reveals a previously unidentified role of laminin-111 in early stem cell differentiation.
Title: Biologically-active laminin-111 fragment that modulates the epithelial-to-mesenchymal transition in embryonic stem cells.
These results suggest the possibility that up-regulation of LAMB1 in podocytes, should it become achievable, would likely lessen the severity of nephrotic syndrome in patients carrying LAMB2 mutations.
Title: Forced expression of laminin beta1 in podocytes prevents nephrotic syndrome in mice lacking laminin beta2, a model for Pierson syndrome.
Laminin beta(1) and gamma(1) N-terminal domains share the galactose-binding domain-like fold.
Title: Computational modeling of laminin N-terminal domains using sparse distance constraints from disulfide bonds and chemical cross-linking.
laminin-111 (alpha(1), beta(1), gamma(1)), which is expressed during embryonic development but absent in normal or dystrophic skeletal muscle, increased alpha(7)-integrin expression in mouse and DMD patient myoblasts
Title: Laminin-111 protein therapy prevents muscle disease in the mdx mouse model for Duchenne muscular dystrophy.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1) 1 citation
Gene trapped (1) 1 citation
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:236828 (e-PCR)
- UniSTS:236828

Lamb1-1 (e-PCR), detects polymorphism
- UniSTS:472866

Lamb1-1 (e-PCR), detects polymorphism
- UniSTS:256620

Lamb1-1 (e-PCR), detects polymorphism
- UniSTS:143751

Lamb1-1 (e-PCR), detects polymorphism
- UniSTS:143752

RH126801 (e-PCR)
- UniSTS:208795

RH126280 (e-PCR)
- UniSTS:162988

C81607 (e-PCR)
- UniSTS:160194

M15525 (e-PCR)
- UniSTS:124921

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables extracellular matrix structural constituent	ISO Inferred from Sequence Orthology more info
enables extracellular matrix structural constituent	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables glycosphingolipid binding	IDA Inferred from Direct Assay more info	PubMed
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of synapse-associated extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in basement membrane assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryo implantation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in learning or memory	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of cell adhesion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in neuronal-glial interaction involved in cerebral cortex radial glia guided migration	ISO Inferred from Sequence Orthology more info
involved_in odontogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell adhesion	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of integrin-mediated signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of muscle cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of basement membrane organization	NAS Non-traceable Author Statement more info	PubMed
involved_in substrate adhesion-dependent cell spreading	IBA Inferred from Biological aspect of Ancestor more info
involved_in substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in tissue development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basement membrane	ISO Inferred from Sequence Orthology more info
located_in basement membrane	NAS Non-traceable Author Statement more info	PubMed
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of laminin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of laminin complex	IDA Inferred from Direct Assay more info	PubMed
part_of laminin-1 complex	IDA Inferred from Direct Assay more info	PubMed
part_of laminin-1 complex	ISO Inferred from Sequence Orthology more info
part_of laminin-10 complex	IPI Inferred from Physical Interaction more info	PubMed
part_of laminin-10 complex	ISO Inferred from Sequence Orthology more info
part_of laminin-2 complex	ISO Inferred from Sequence Orthology more info
part_of laminin-8 complex	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of protein complex involved in cell-matrix adhesion	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: laminin subunit beta-1

Names: laminin B1 chain; laminin B1 subunit 1; laminin-1 subunit beta; laminin-10 subunit beta; laminin-111; laminin-12 subunit beta; laminin-2 subunit beta; laminin-6 subunit beta; laminin-8 subunit beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008482.3 → NP_032508.3 laminin subunit beta-1 precursor

Status: VALIDATED

Source sequence(s)

CR974423, CT571245

Consensus CDS

CCDS25862.2

UniProtKB/Swiss-Prot

E9PXZ9, P02469

UniProtKB/TrEMBL

E9QN70

Related

ENSMUSP00000002979.10, ENSMUST00000002979.16

Conserved Domains (6) summary

pfam05483
Location:1201 → 1667

SCP-1; Synaptonemal complex protein 1 (SCP-1)

smart00180
Location:773 → 818

EGF_Lam; Laminin-type epidermal growth factor-like domai

cd00055
Location:509 → 548

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

TIGR02168
Location:1456 → 1776

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam00053
Location:821 → 869

Laminin_EGF; Laminin EGF domain

pfam00055
Location:44 → 269

Laminin_N; Laminin N-terminal (Domain VI)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

31315230..31379643

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006514993.2 → XP_006515056.1 laminin subunit beta-1 isoform X1

See identical proteins and their annotated locations for XP_006515056.1

UniProtKB/Swiss-Prot

E9PXZ9, P02469

UniProtKB/TrEMBL

E9QN70

Related

ENSMUSP00000132778.2, ENSMUST00000169088.8

Conserved Domains (6) summary

pfam05483
Location:1201 → 1667

SCP-1; Synaptonemal complex protein 1 (SCP-1)

smart00180
Location:773 → 818

EGF_Lam; Laminin-type epidermal growth factor-like domai

cd00055
Location:509 → 548

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

TIGR02168
Location:1456 → 1776

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam00053
Location:821 → 869

Laminin_EGF; Laminin EGF domain

pfam00055
Location:44 → 269

Laminin_N; Laminin N-terminal (Domain VI)