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    Lag3 lymphocyte-activation gene 3 [ Mus musculus (house mouse) ]

    Gene ID: 16768, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Lag3provided by MGI
    Official Full Name
    lymphocyte-activation gene 3provided by MGI
    Primary source
    MGI:MGI:106588
    See related
    Ensembl:ENSMUSG00000030124 AllianceGenome:MGI:106588
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ly66; CD223; LAG-3
    Summary
    Enables MHC class II protein binding activity and transmembrane signaling receptor activity. Involved in negative regulation of regulatory T cell differentiation; plasmacytoid dendritic cell activation; and regulation of immune response. Acts upstream of or within cell surface receptor signaling pathway; negative regulation of interleukin-2 production; and positive regulation of natural killer cell mediated cytotoxicity. Located in external side of plasma membrane and extracellular region. Orthologous to human LAG3 (lymphocyte activating 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in thymus adult (RPKM 7.2), spleen adult (RPKM 4.9) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 F2; 6 59.17 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (124881322..124888668, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (124904359..124912434, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32404 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:124812982-124813183 Neighboring gene G protein-coupled receptor 162 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:124814119-124814302 Neighboring gene CD4 antigen Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:124829493-124829732 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:124836126-124836313 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:124850419-124850700 Neighboring gene STARR-positive B cell enhancer ABC_E4863 Neighboring gene STARR-positive B cell enhancer ABC_E1710 Neighboring gene RIKEN cDNA A230083G16 gene Neighboring gene STARR-seq mESC enhancer starr_17314 Neighboring gene parathymosin Neighboring gene predicted gene, 38896

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Signatures of glial activity can be detected in the CSF proteome. Eninger T, et al. Proc Natl Acad Sci U S A, 2022 Jun 14. PMID 35666874, Free PMC Article
    2. Binding of LAG-3 to stable peptide-MHC class II limits T cell function and suppresses autoimmunity and anti-cancer immunity. Maruhashi T, et al. Immunity, 2022 May 10. PMID 35413245
    3. Lymphocyte Activation Gene-3 Regulates Dendritic Cell Metabolic Programing and T Cell Priming Function. Garcia Cruz D, et al. J Immunol, 2021 Nov 1. PMID 34588222, Free PMC Article
    4. Small Molecule Inhibition of GSK-3 Specifically Inhibits the Transcription of Inhibitory Co-receptor LAG-3 for Enhanced Anti-tumor Immunity. Rudd CE, et al. Cell Rep, 2020 Feb 18. PMID 32075731
    5. Double negative T cells mediate Lag3-dependent antigen-specific protection in allergic asthma. Tian D, et al. Nat Commun, 2019 Sep 18. PMID 31534137, Free PMC Article

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural insights reveal interplay between LAG-3 homodimerization, ligand binding, and function.
      Title: Structural insights reveal interplay between LAG-3 homodimerization, ligand binding, and function.
    2. Cerebral Microvascular Injury Induced by Lag3-Dependent alpha-Synuclein Fibril Endocytosis Exacerbates Cognitive Impairment in a Mouse Model of alpha-Synucleinopathies.
      Title: Cerebral Microvascular Injury Induced by Lag3-Dependent α-Synuclein Fibril Endocytosis Exacerbates Cognitive Impairment in a Mouse Model of α-Synucleinopathies.
    3. [LAG3 intracytoplasmic acidic environment locally disrupts the association of the Lck kinase to CD4 and CD8, two co-receptors of the TCR].
      Title: [LAG3 intracytoplasmic acidic environment locally disrupts the association of the Lck kinase to CD4 and CD8, two co-receptors of the TCR].
    4. LAG3 ectodomain structure reveals functional interfaces for ligand and antibody recognition.
      Title: LAG3 ectodomain structure reveals functional interfaces for ligand and antibody recognition.
    5. Binding of LAG-3 to stable peptide-MHC class II limits T cell function and suppresses autoimmunity and anti-cancer immunity.
      Title: Binding of LAG-3 to stable peptide-MHC class II limits T cell function and suppresses autoimmunity and anti-cancer immunity.
    6. T cells expressing multiple co-inhibitory molecules in acute malaria are not exhausted but exert a suppressive function in mice.
      Title: T cells expressing multiple co-inhibitory molecules in acute malaria are not exhausted but exert a suppressive function in mice.
    7. Mechanistic basis for receptor-mediated pathological alpha-synuclein fibril cell-to-cell transmission in Parkinson's disease.
      Title: Mechanistic basis for receptor-mediated pathological α-synuclein fibril cell-to-cell transmission in Parkinson's disease.
    8. Lymphocyte Activation Gene-3 Regulates Dendritic Cell Metabolic Programing and T Cell Priming Function.
      Title: Lymphocyte Activation Gene-3 Regulates Dendritic Cell Metabolic Programing and T Cell Priming Function.
    9. LAG3 is not expressed in human and murine neurons and does not modulate alpha-synucleinopathies.
      Title: LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies.
    10. Small Molecule Inhibition of GSK-3 Specifically Inhibits the Transcription of Inhibitory Co-receptor LAG-3 for Enhanced Anti-tumor Immunity.
      Title: Small Molecule Inhibition of GSK-3 Specifically Inhibits the Transcription of Inhibitory Co-receptor LAG-3 for Enhanced Anti-tumor Immunity.
    Submit: New GeneRIF Correction See all GeneRIFs (48)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MHC class II protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MHC class II protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables MHC class II protein binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of T cell activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell surface receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell surface receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of interleukin-2 production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of natural killer cell mediated cytotoxicity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of natural killer cell mediated cytotoxicity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of T cell activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of T cell activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of interleukin-2 production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of regulatory T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in plasmacytoid dendritic cell activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of natural killer cell mediated cytotoxicity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of natural killer cell mediated cytotoxicity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lymphocyte activation gene 3 protein
    Names
    activation-induced cytidine deaminase-linked autoimmunity protein
    aida

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008479.2 → NP_032505.1  lymphocyte activation gene 3 protein precursor

      See identical proteins and their annotated locations for NP_032505.1

      Status: VALIDATED

      Source sequence(s)
      AC142254, BC120591, CO040235
      Consensus CDS
      CCDS20536.1
      UniProtKB/Swiss-Prot
      Q0VBL2, Q61790
      Related
      ENSMUSP00000032217.2, ENSMUST00000032217.2
      Conserved Domains (3) summary
      smart00410
      Location:261 → 344
      IG_like; Immunoglobulin like
      pfam00047
      Location:168 → 246
      ig; Immunoglobulin domain
      cl11960
      Location:261 → 344
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      124881322..124888668 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61790.1 GenPept UniProtKB/Swiss-Prot:Q61790

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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