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    Ksr1 kinase suppressor of ras 1 [ Mus musculus (house mouse) ]

    Gene ID: 16706, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Ksr1provided by MGI
    Official Full Name
    kinase suppressor of ras 1provided by MGI
    Primary source
    MGI:MGI:105051
    See related
    Ensembl:ENSMUSG00000018334 AllianceGenome:MGI:105051
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    hb; Ksr; RSU2; mKSR1; B-KSR1; D11Bhm183e; D11Bhm184e
    Summary
    Enables several functions, including 14-3-3 protein binding activity; ATP binding activity; and Hsp90 protein binding activity. Involved in intracellular signal transduction; regulation of MAP kinase activity; and regulation of cell population proliferation. Acts upstream of or within positive regulation of MAPK cascade. Predicted to be located in cell projection and plasma membrane. Predicted to be part of protein-containing complex. Predicted to be active in endoplasmic reticulum and membrane. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and lung. Human ortholog(s) of this gene implicated in breast adenocarcinoma. Orthologous to human KSR1 (kinase suppressor of ras 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 15.8), small intestine adult (RPKM 14.1) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 B5; 11 46.74 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (78904266..79037357, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (79013440..79146533, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene Nos2 promoter region Neighboring gene nitric oxide synthase 2, inducible Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:78787018-78787219 Neighboring gene lectin, galactose binding, soluble 9 Neighboring gene STARR-seq mESC enhancer starr_30105 Neighboring gene STARR-seq mESC enhancer starr_30106 Neighboring gene STARR-positive B cell enhancer ABC_E5251 Neighboring gene predicted gene 11201 Neighboring gene STARR-seq mESC enhancer starr_30109 Neighboring gene STARR-positive B cell enhancer ABC_E5252 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:78955902-78956103 Neighboring gene STARR-positive B cell enhancer ABC_E10696 Neighboring gene predicted gene, 30413 Neighboring gene STARR-positive B cell enhancer ABC_E5253 Neighboring gene STARR-seq mESC enhancer starr_30112 Neighboring gene predicted gene, 30470 Neighboring gene WD repeat and SOCS box-containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Calmodulin influences MAPK signaling by binding KSR1. Parvathaneni S, et al. J Biol Chem, 2021 Jan-Jun. PMID 33766558, Free PMC Article
    2. Tyr728 in the kinase domain of the murine kinase suppressor of RAS 1 regulates binding and activation of the mitogen-activated protein kinase kinase. Sibilski C, et al. J Biol Chem, 2013 Dec 6. PMID 24158441, Free PMC Article
    3. Kinase suppressor of Ras 1 is not required for the generation of regulatory and memory T cells. Le Borgne M, et al. PLoS One, 2013. PMID 23431403, Free PMC Article
    4. Role of kinase suppressor of ras-1 in lipopolysaccharide-induced acute lung injury. Li X, et al. Cell Physiol Biochem, 2012. PMID 23221422, Free PMC Article
    5. Suppression of Ras/Mapk pathway signaling inhibits Myc-induced lymphomagenesis. Gramling MW, et al. Cell Death Differ, 2012 Jul. PMID 22301919, Free PMC Article

    See all (89) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Calmodulin influences MAPK signaling by binding KSR1.
      Title: Calmodulin influences MAPK signaling by binding KSR1.
    2. DiRas3 binds to KSR1 independently of its interaction with activated Ras and RAF.
      Title: Stabilization of C-RAF:KSR1 complex by DiRas3 reduces availability of C-RAF for dimerization with B-RAF.
    3. praja2 regulates KSR1 stability and mitogenic signaling.
      Title: praja2 regulates KSR1 stability and mitogenic signaling.
    4. These results suggest that Rap1 activation of ERKs requires PKA phosphorylation and KSR binding.
      Title: Phosphorylation of Rap1 by cAMP-dependent Protein Kinase (PKA) Creates a Binding Site for KSR to Sustain ERK Activation by cAMP.
    5. Data show that caveolin-1 is necessary for optimal KSR1-dependent ERK activation by growth factors and oncogenic Ras.
      Title: Caveolin-1 is required for kinase suppressor of Ras 1 (KSR1)-mediated extracellular signal-regulated kinase 1/2 activation, H-RasV12-induced senescence, and transformation.
    6. propose that phosphorylation of Tyr(728) may regulate the transition between the scaffolding and the catalytic function of KSR1 serving as a control point used to fine-tune cellular responses
      Title: Tyr728 in the kinase domain of the murine kinase suppressor of RAS 1 regulates binding and activation of the mitogen-activated protein kinase kinase.
    7. Data indicate that phosphorylation of BRAF by AMPK disrupts its association with KSR1.
      Title: Phosphorylation of BRAF by AMPK impairs BRAF-KSR1 association and cell proliferation.
    8. Despite its role in mTORC1 activation, KSR1 is not required in vivo for mTOR-dependent T cell differentiation.
      Title: Kinase suppressor of Ras 1 is not required for the generation of regulatory and memory T cells.
    9. Ksr1 plays a dispensable role in lipopolysaccharide (LPS)-induced ERK activation in alveolar macrophages and does not contribute to the development of acute lung injury in the LPS model.
      Title: Role of kinase suppressor of ras-1 in lipopolysaccharide-induced acute lung injury.
    10. the atypical C1 domain, the CC-SAM domain is required to target KSR-1 to the plasma membrane.
      Title: A CC-SAM, for coiled coil-sterile α motif, domain targets the scaffold KSR-1 to specific sites in the plasma membrane.
    Submit: New GeneRIF Correction See all GeneRIFs (34)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 14-3-3 protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables 14-3-3 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables Hsp90 protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables MAP-kinase scaffold activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables MAP-kinase scaffold activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mitogen-activated protein kinase kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables mitogen-activated protein kinase kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-folding chaperone binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within MAPK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Ras protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cAMP-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of MAP kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kinase suppressor of Ras 1
    Names
    protein Hb
    NP_001335136.1
    NP_038599.1
    XP_006532397.1
    XP_006532398.1
    XP_011247072.1
    XP_011247073.1
    XP_011247074.1
    XP_011247075.1
    XP_011247076.1
    XP_011247077.1
    XP_036012252.1
    XP_036012253.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001348207.1 → NP_001335136.1  kinase suppressor of Ras 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK137532, CX204281, U43585
      Consensus CDS
      CCDS88203.1
      UniProtKB/TrEMBL
      A0A2I3BR95, Q3UV75
      Related
      ENSMUSP00000154385.2, ENSMUST00000226282.2
      Conserved Domains (3) summary
      cd00029
      Location:252 → 294
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd14152
      Location:480 → 758
      STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
      pfam13543
      Location:42 → 84
      KSR1-SAM; SAM like domain present in kinase suppressor RAS 1

    2. NM_013571.3 → NP_038599.1  kinase suppressor of Ras 1 isoform 1

      See identical proteins and their annotated locations for NP_038599.1

      Status: VALIDATED

      Source sequence(s)
      AK137532, AK164833, CX204281, U43585
      Consensus CDS
      CCDS25117.1
      UniProtKB/Swiss-Prot
      Q61097, Q61648, Q78DX8
      UniProtKB/TrEMBL
      Q3UV75
      Related
      ENSMUSP00000018478.5, ENSMUST00000018478.11
      Conserved Domains (4) summary
      cd00029
      Location:334 → 376
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd14152
      Location:562 → 840
      STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
      pfam07714
      Location:563 → 827
      Pkinase_Tyr; Protein tyrosine kinase
      pfam13543
      Location:39 → 166
      KSR1-SAM; SAM like domain present in kinase suppressor RAS 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      78904266..79037357 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248771.4 → XP_011247073.1  kinase suppressor of Ras 1 isoform X2

      UniProtKB/TrEMBL
      Q3UV75
      Conserved Domains (3) summary
      cd00029
      Location:334 → 376
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd14152
      Location:562 → 840
      STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
      pfam13543
      Location:39 → 166
      KSR1-SAM; SAM like domain present in kinase suppressor RAS 1

    2. XM_011248770.4 → XP_011247072.1  kinase suppressor of Ras 1 isoform X1

      UniProtKB/TrEMBL
      Q3UV75
      Conserved Domains (3) summary
      cd00029
      Location:334 → 376
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd14152
      Location:576 → 854
      STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
      pfam13543
      Location:39 → 166
      KSR1-SAM; SAM like domain present in kinase suppressor RAS 1

    3. XM_036156359.1 → XP_036012252.1  kinase suppressor of Ras 1 isoform X3

      UniProtKB/TrEMBL
      Q3UV75
      Conserved Domains (3) summary
      cd14152
      Location:576 → 854
      STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
      pfam13543
      Location:39 → 166
      KSR1-SAM; SAM like domain present in kinase suppressor RAS 1
      cd20872
      Location:332 → 378
      C1_KSR1; protein kinase C conserved region 1 (C1 domain) found in kinase suppressor of Ras 1 (KSR1) and similar proteins

    4. XM_036156360.1 → XP_036012253.1  kinase suppressor of Ras 1 isoform X7

      UniProtKB/TrEMBL
      Q3UV75
      Conserved Domains (3) summary
      cd14152
      Location:562 → 840
      STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
      pfam13543
      Location:39 → 166
      KSR1-SAM; SAM like domain present in kinase suppressor RAS 1
      cd20872
      Location:332 → 378
      C1_KSR1; protein kinase C conserved region 1 (C1 domain) found in kinase suppressor of Ras 1 (KSR1) and similar proteins

    5. XM_006532334.5 → XP_006532397.1  kinase suppressor of Ras 1 isoform X5

      UniProtKB/TrEMBL
      Q3UV75
      Conserved Domains (3) summary
      cd00029
      Location:334 → 376
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd14152
      Location:576 → 854
      STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
      pfam13543
      Location:39 → 166
      KSR1-SAM; SAM like domain present in kinase suppressor RAS 1

    6. XM_006532335.5 → XP_006532398.1  kinase suppressor of Ras 1 isoform X6

      UniProtKB/TrEMBL
      Q3UV75
      Conserved Domains (3) summary
      cd00029
      Location:334 → 376
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd14152
      Location:576 → 854
      STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
      pfam13543
      Location:39 → 166
      KSR1-SAM; SAM like domain present in kinase suppressor RAS 1

    7. XM_011248775.3 → XP_011247077.1  kinase suppressor of Ras 1 isoform X4

      See identical proteins and their annotated locations for XP_011247077.1

      UniProtKB/TrEMBL
      Q3UV75
      Conserved Domains (2) summary
      cd00029
      Location:199 → 241
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd14152
      Location:441 → 719
      STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1

    8. XM_011248772.3 → XP_011247074.1  kinase suppressor of Ras 1 isoform X4

      See identical proteins and their annotated locations for XP_011247074.1

      UniProtKB/TrEMBL
      Q3UV75
      Conserved Domains (2) summary
      cd00029
      Location:199 → 241
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd14152
      Location:441 → 719
      STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1

    9. XM_011248774.4 → XP_011247076.1  kinase suppressor of Ras 1 isoform X9

      UniProtKB/TrEMBL
      Q3UV75
      Conserved Domains (3) summary
      cd00029
      Location:220 → 262
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd14152
      Location:462 → 740
      STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
      pfam13543
      Location:1 → 52
      KSR1-SAM; SAM like domain present in kinase suppressor RAS 1

    10. XM_011248773.4 → XP_011247075.1  kinase suppressor of Ras 1 isoform X8

      UniProtKB/TrEMBL
      Q3UV75
      Conserved Domains (3) summary
      cd00029
      Location:252 → 294
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd14152
      Location:494 → 772
      STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
      pfam13543
      Location:42 → 84
      KSR1-SAM; SAM like domain present in kinase suppressor RAS 1

    RNA

    1. XR_004936797.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61097.1 GenPept UniProtKB/Swiss-Prot:Q61097

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