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    Krt36 keratin 36 [ Mus musculus (house mouse) ]

    Gene ID: 16673, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Krt36provided by MGI
    Official Full Name
    keratin 36provided by MGI
    Primary source
    MGI:MGI:109364
    See related
    Ensembl:ENSMUSG00000020916 AllianceGenome:MGI:109364
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    K36; HRa-1; Krt1-5; MHRa-1; Krt1-22
    Summary
    A structural constituent of skin epidermis. Involved in regulation of keratinocyte differentiation. Located in intermediate filament cytoskeleton. Is expressed in filiform papillae and tongue. Orthologous to human KRT36 (keratin 36). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in mammary gland adult (RPKM 2.2), subcutaneous fat pad adult (RPKM 0.7) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 D; 11 63.41 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (99992838..100000301, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100102012..100109487, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11571 Neighboring gene keratin 32 Neighboring gene STARR-seq mESC enhancer starr_30712 Neighboring gene keratin 35 Neighboring gene keratin 13 Neighboring gene keratin 15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Structural features and sites of expression of a new murine 65 kD and 48 kD hair-related keratin pair, associated with a special type of parakeratotic epithelial differentiation. Tobiasch E, et al. Differentiation, 1992 Aug. PMID 1385239
    2. Regional regulation of Filiform tongue papillae development by Ikkα/Irf6. Kawasaki M, et al. Dev Dyn, 2016 Sep. PMID 27302476
    3. Pax9 is required for filiform papilla development and suppresses skin-specific differentiation of the mammalian tongue epithelium. Jonker L, et al. Mech Dev, 2004 Nov. PMID 15454262
    4. WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation. Xu M, et al. Nat Commun, 2017 Jun 7. PMID 28589954, Free PMC Article
    5. DYRK1a mediates BAFF-induced noncanonical NF-κB activation to promote autoimmunity and B-cell leukemogenesis. Li Y, et al. Blood, 2021 Dec 9. PMID 34255829, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. E3 ubiquitin ligase RNF187 promotes growth of spermatogonia via lysine 48-linked polyubiquitination-mediated degradation of KRT36/KRT84.
      Title: E3 ubiquitin ligase RNF187 promotes growth of spermatogonia via lysine 48-linked polyubiquitination-mediated degradation of KRT36/KRT84.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of skin epidermis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of skin epidermis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in epithelial cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of keratinocyte differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in intermediate filament cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intermediate filament cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in keratin filament ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    keratin, type I cuticular Ha6
    Names
    keratin complex 1, acidic, gene 5
    keratin-5
    type I keratin 48 kDa (MHRa-1)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001174099.1 → NP_001167570.1  keratin, type I cuticular Ha6

      See identical proteins and their annotated locations for NP_001167570.1

      Status: VALIDATED

      Source sequence(s)
      AL590873, AL662808
      Consensus CDS
      CCDS48929.1
      UniProtKB/Swiss-Prot
      B1AQ75, Q61861
      Related
      ENSMUSP00000103039.3, ENSMUST00000107416.3
      Conserved Domains (1) summary
      pfam00038
      Location:92 → 403
      Filament; Intermediate filament protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      99992838..100000301 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314302.2 → XP_017169791.1  keratin, type I cuticular Ha6 isoform X1

      UniProtKB/Swiss-Prot
      B1AQ75, Q61861
      Conserved Domains (1) summary
      pfam00038
      Location:92 → 403
      Filament; Intermediate filament protein

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_008472.2: Suppressed sequence

      Description
      NM_008472.2: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.

    2. NR_003957.1: Suppressed sequence

      Description
      NR_003957.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B1AQ75.1 GenPept UniProtKB/Swiss-Prot:B1AQ75

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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