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    Krt32 keratin 32 [ Mus musculus (house mouse) ]

    Gene ID: 16670, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Krt32provided by MGI
    Official Full Name
    keratin 32provided by MGI
    Primary source
    MGI:MGI:1309995
    See related
    Ensembl:ENSMUSG00000046095 AllianceGenome:MGI:1309995
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ha3; K32; Hka2; Krt1-2; Krtha2
    Summary
    Predicted to enable structural molecule activity. Predicted to be located in intermediate filament. Is expressed in esophagus; jaw bone; lung; skin; and urethra. Orthologous to human KRT32 (keratin 32). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in lung adult (RPKM 3.1), stomach adult (RPKM 1.0) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 D; 11 63.4 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (99971674..99979095, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100080848..100088269, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene keratin 34 Neighboring gene keratin 31 Neighboring gene predicted gene 11571 Neighboring gene STARR-seq mESC enhancer starr_30712 Neighboring gene keratin 35 Neighboring gene keratin 36

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Whn and mHa3 are components of the genetic hierarchy controlling hair follicle differentiation. Meier N, et al. Mech Dev, 1999 Dec. PMID 10559501
    2. Spatiotemporal expression pattern of keratins in skin of AP-2alpha-deficient mice. Talbot D, et al. J Invest Dermatol, 1999 Nov. PMID 10571739
    3. Sequence and expression of murine type I hair keratins mHa2 and mHa3. Winter H, et al. Exp Cell Res, 1994 Jun. PMID 7514534
    4. Quantitative trait loci for steady-state platelet count in mice. Cheung CC, et al. Mamm Genome, 2004 Oct. PMID 15520881
    5. beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Huelsken J, et al. Cell, 2001 May 18. PMID 11371349

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC144672, MGC144673

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in epithelial cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    keratin, type I cuticular Ha2
    Names
    hair keratin, type I Ha2
    keratin complex 1, acidic, gene 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159374.3 → NP_001152846.2  keratin, type I cuticular Ha2

      Status: VALIDATED

      Source sequence(s)
      AL662808
      Consensus CDS
      CCDS56805.1
      UniProtKB/Swiss-Prot
      Q148N4, Q62168
      UniProtKB/TrEMBL
      B1ATJ5
      Related
      ENSMUSP00000103042.2, ENSMUST00000107419.3
      Conserved Domains (3) summary
      pfam00038
      Location:100 → 411
      Filament; Intermediate filament protein
      pfam05287
      Location:1 → 92
      PMG; PMG protein
      pfam16043
      Location:102 → 256
      DUF4795; Domain of unknown function (DUF4795)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      99971674..99979095 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_010665.2: Suppressed sequence

      Description
      NM_010665.2: This RefSeq was temporarily suppressed because the CDS was partial.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62168.2 GenPept UniProtKB/Swiss-Prot:Q62168

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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