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    Kifc2 kinesin family member C2 [ Mus musculus (house mouse) ]

    Gene ID: 16581, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Kifc2provided by MGI
    Official Full Name
    kinesin family member C2provided by MGI
    Primary source
    MGI:MGI:109187
    See related
    Ensembl:ENSMUSG00000004187 AllianceGenome:MGI:109187
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in microtubule-based movement and mitotic spindle assembly. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be part of kinesin complex. Predicted to be active in microtubule cytoskeleton and nucleus. Is expressed in several structures, including 4-cell stage embryo; alimentary system; genitourinary system; nervous system; and sensory organ. Orthologous to human KIFC2 (kinesin family member C2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cortex adult (RPKM 113.0), frontal lobe adult (RPKM 87.4) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 D3; 15 36.23 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76543984..76552396)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76659784..76668196)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene tonsoku-like, DNA repair protein Neighboring gene STARR-positive B cell enhancer ABC_E1481 Neighboring gene zinc finger TRAF type containing 1 Neighboring gene predicted gene, 57852 Neighboring gene STARR-positive B cell enhancer ABC_E760 Neighboring gene STARR-positive B cell enhancer ABC_E9419 Neighboring gene STARR-positive B cell enhancer ABC_E3145 Neighboring gene transmembrane protein 276 Neighboring gene STARR-positive B cell enhancer ABC_E5491 Neighboring gene forkhead box H1 Neighboring gene STARR-seq mESC enhancer starr_39060 Neighboring gene protein phosphatase 1, regulatory subunit 16A Neighboring gene glutamic pyruvic transaminase, soluble

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Functional analysis of mouse C-terminal kinesin motor KifC2. Yang Z, et al. Mol Cell Biol, 2001 Apr. PMID 11259594, Free PMC Article
    2. Characterization of KIFC2, a neuronal kinesin superfamily member in mouse. Hanlon DW, et al. Neuron, 1997 Mar. PMID 9115737
    3. KIFC2 is a novel neuron-specific C-terminal type kinesin superfamily motor for dendritic transport of multivesicular body-like organelles. Saito N, et al. Neuron, 1997 Mar. PMID 9115736
    4. Kif5B and Kifc1 interact and are required for motility and fission of early endocytic vesicles in mouse liver. Nath S, et al. Mol Biol Cell, 2007 May. PMID 17360972, Free PMC Article
    5. T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis. Venables JP, et al. Hum Mol Genet, 1999 Jun. PMID 10332027

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT located_in endocytic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kinesin-like protein KIFC2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358909.2 → NP_001345838.1  kinesin-like protein KIFC2 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (4) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC156550
      Consensus CDS
      CCDS88791.1
      UniProtKB/TrEMBL
      A0A2R8W6X1, Q3UNC4
      Related
      ENSMUSP00000155536.2, ENSMUST00000230451.2
      Conserved Domains (2) summary
      COG1196
      Location:145 → 266
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01366
      Location:322 → 649
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

    2. NM_001358910.2 → NP_001345839.1  kinesin-like protein KIFC2 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (4) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC156550
      Consensus CDS
      CCDS88791.1
      UniProtKB/TrEMBL
      A0A2R8W6X1, Q3UNC4
      Conserved Domains (2) summary
      COG1196
      Location:145 → 266
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01366
      Location:322 → 649
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

    3. NM_001358911.2 → NP_001345840.1  kinesin-like protein KIFC2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC156550
      UniProtKB/Swiss-Prot
      O08613, O08672
      Conserved Domains (2) summary
      cd01366
      Location:390 → 717
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
      cl25732
      Location:224 → 336
      SMC_N; RecF/RecN/SMC N terminal domain

    4. NM_001358912.2 → NP_001345841.1  kinesin-like protein KIFC2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AC156550
      UniProtKB/Swiss-Prot
      O08613, O08672
      Conserved Domains (2) summary
      cd01366
      Location:387 → 714
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
      cl25732
      Location:237 → 325
      SMC_N; RecF/RecN/SMC N terminal domain

    5. NM_001416290.1 → NP_001403219.1  kinesin-like protein KIFC2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC156550
      UniProtKB/TrEMBL
      A0A2R8W6X1

    6. NM_001416296.1 → NP_001403225.1  kinesin-like protein KIFC2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC156550

    7. NM_001416297.1 → NP_001403226.1  kinesin-like protein KIFC2 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC156550

    8. NM_001416298.1 → NP_001403227.1  kinesin-like protein KIFC2 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC156550

    9. NM_001416299.1 → NP_001403228.1  kinesin-like protein KIFC2 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC156550

    10. NM_001416300.1 → NP_001403229.1  kinesin-like protein KIFC2 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC156550

    11. NM_001416301.1 → NP_001403230.1  kinesin-like protein KIFC2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC156550

    12. NM_001416302.1 → NP_001403231.1  kinesin-like protein KIFC2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC156550

    13. NM_001416303.1 → NP_001403232.1  kinesin-like protein KIFC2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC156550

    14. NM_001416304.1 → NP_001403233.1  kinesin-like protein KIFC2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC156550

    15. NM_001416305.1 → NP_001403234.1  kinesin-like protein KIFC2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC156550

    16. NM_001416306.1 → NP_001403235.1  kinesin-like protein KIFC2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC156550

    17. NM_001416307.1 → NP_001403236.1  kinesin-like protein KIFC2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC156550

    18. NM_001416308.1 → NP_001403237.1  kinesin-like protein KIFC2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC156550

    19. NM_010630.4 → NP_034760.2  kinesin-like protein KIFC2 isoform 1

      See identical proteins and their annotated locations for NP_034760.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC156550
      Consensus CDS
      CCDS27583.1
      UniProtKB/Swiss-Prot
      O08613, O08672
      UniProtKB/TrEMBL
      G3X8Q6
      Related
      ENSMUSP00000004294.11, ENSMUST00000004294.12
      Conserved Domains (2) summary
      smart00129
      Location:409 → 735
      KISc; Kinesin motor, catalytic domain. ATPase
      cd01366
      Location:407 → 734
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

    RNA

    1. NR_183664.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC156550

    2. NR_183665.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC156550
      Related
      ENSMUST00000230964.2

    3. NR_183666.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC156550

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      76543984..76552396
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248350.2 → XP_030104210.1  kinesin-like protein KIFC2 isoform X3

      Conserved Domains (1) summary
      cd01366
      Location:68 → 395
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

    2. XM_030248356.1 → XP_030104216.1  kinesin-like protein KIFC2 isoform X3

      Conserved Domains (1) summary
      cd01366
      Location:68 → 395
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

    3. XM_030248351.1 → XP_030104211.1  kinesin-like protein KIFC2 isoform X3

      Conserved Domains (1) summary
      cd01366
      Location:68 → 395
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

    4. XM_030248349.1 → XP_030104209.1  kinesin-like protein KIFC2 isoform X3

      Conserved Domains (1) summary
      cd01366
      Location:68 → 395
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

    5. XM_030248346.2 → XP_030104206.1  kinesin-like protein KIFC2 isoform X1

      UniProtKB/TrEMBL
      A0A2R8W6X1, Q3UNC4
      Related
      ENSMUST00000230124.2
      Conserved Domains (2) summary
      COG1196
      Location:145 → 266
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01366
      Location:322 → 649
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

    6. XM_036159191.1 → XP_036015084.1  kinesin-like protein KIFC2 isoform X2

      UniProtKB/TrEMBL
      Q3UNC4
      Conserved Domains (1) summary
      cd01366
      Location:305 → 632
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

    7. XM_036159193.1 → XP_036015086.1  kinesin-like protein KIFC2 isoform X3

      Conserved Domains (1) summary
      cd01366
      Location:68 → 395
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

    RNA

    1. XR_383988.3 RNA Sequence

    2. XR_001781497.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O08672.1 GenPept UniProtKB/Swiss-Prot:O08672

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