Kif2a kinesin family member 2A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kif2aprovided by MGI
Official Full Name: kinesin family member 2Aprovided by MGI
Primary source: MGI:MGI:108390
See related: Ensembl:ENSMUSG00000021693 AllianceGenome:MGI:108390
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Kif2; Kns2; M-kinesin; C530030B14Rik
Summary: Predicted to enable several functions, including ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in microtubule-based movement; mitotic spindle assembly; and regulation of cell migration. Predicted to act upstream of or within cell differentiation; cell division; and nervous system development. Located in sperm principal piece. Is expressed in central nervous system and dorsal root ganglion. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 3. Orthologous to human KIF2A (kinesin family member 2A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E18 (RPKM 12.1), frontal lobe adult (RPKM 11.5) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 D2.1; 13 58.06 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (107095504..107158931, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (106958996..107022355, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KIF2A deficiency causes early-onset neurodegeneration.
Title: KIF2A deficiency causes early-onset neurodegeneration.
The Celsr3-Kif2a axis directs neuronal migration in the postnatal brain.
Title: The Celsr3-Kif2a axis directs neuronal migration in the postnatal brain.
KIF3A accelerates KIF3C within the kinesin-2 heterodimer to generate symmetrical phosphate release rates for each processive step.
Title: KIF3A accelerates KIF3C within the kinesin-2 heterodimer to generate symmetrical phosphate release rates for each processive step.
Roles of developmentally regulated KIF2A alternative isoforms in cortical neuron migration and differentiation.
Title: Roles of developmentally regulated KIF2A alternative isoforms in cortical neuron migration and differentiation.
Conditional switching of KIF2A mutation provides new insights into cortical malformation pathogeny.
Title: Conditional switching of KIF2A mutation provides new insights into cortical malformation pathogeny.
These results suggested that postnatal KIF2A is a key length regulator of DGC developing neurites and is involved in the establishment of precise postnatal hippocampal wiring.
Title: KIF2A regulates the development of dentate granule cells and postnatal hippocampal wiring.
Study in mutant mice and human cerebral organoids showed that WDR62 deletion resulted in a reduction in the size of mouse brains and organoids due to the disruption of neural progenitor cells. WDR62 interacts with and promotes CEP170 localization to the basal body of primary cilium, where CEP170 recruits KIF2A to disassemble cilium.
Title: Modeling microcephaly with cerebral organoids reveals a WDR62-CEP170-KIF2A pathway promoting cilium disassembly in neural progenitors.
Heterodimeric KIF3AC and KIF3AB, two members of the mammalian kinesin-2 family, generate force for microtubule plus end-directed cargo transport. This study reveals the impact of heterodimerization of the motor polypeptides for microtubule association to start the processive run and the fundamental differences in the motile properties of KIF3C compared with KIF3A and KIF3B.
Title: Kinesin-2 heterodimerization alters entry into a processive run along the microtubule but not stepping within the run.
These data indicate that KIF2A regulates the spindle assembly, asymmetric cytokinesis and the metaphase I-anaphase I transition in mouse oocyte.
Title: KIF2A regulates the spindle assembly and the metaphase I-anaphase I transition in mouse oocyte.
Kif2a may act as a microtubule depolymerase, regulating microtubule dynamics, spindle assembly and chromosome congression, and thus cell cycle progression during mouse oocyte meiotic maturation.
Title: Kif2a regulates spindle organization and cell cycle progression in meiotic oocytes.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (2) 1 citation
Targeted (5) 1 citation
Endonuclease-mediated (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237105

AU015682 (e-PCR)
- UniSTS:208988

RH125656 (e-PCR)
- UniSTS:162442

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in dendritic transport	IDA Inferred from Direct Assay more info	PubMed
involved_in dendritic transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle assembly	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell migration	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
part_of centriolar subdistal appendage	ISO Inferred from Sequence Orthology more info
located_in centriole	ISO Inferred from Sequence Orthology more info
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with microtubule	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in sperm principal piece	IDA Inferred from Direct Assay more info	PubMed
is_active_in spindle	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with spindle microtubule	ISO Inferred from Sequence Orthology more info
colocalizes_with spindle pole	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: kinesin-like protein KIF2A

Names: kinesin heavy chain member 2; kinesin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001145779.1 → NP_001139251.1 kinesin-like protein KIF2A isoform 2

See identical proteins and their annotated locations for NP_001139251.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region and in the 3' coding region, compared to variant 1. An upstream start codon with a strong Kozak signal is used by this variant. The predicted protein (isoform 2) has a longer and distinct N-terminus and a shorter C-terminus when it is compared to isoform 1.

Source sequence(s)

AC154257, AC154328, AK016720, AK037037, CF581603

Consensus CDS

CCDS49356.1

UniProtKB/Swiss-Prot

O54744, P28740, Q91W03

UniProtKB/TrEMBL

F8VQ42

Related

ENSMUSP00000022204.10, ENSMUST00000022204.16

Conserved Domains (1) summary

cd01367
Location:222 → 550

KISc_KIF2_like; Kinesin motor domain, KIF2-like group
NM_001374727.1 → NP_001361656.1 kinesin-like protein KIF2A isoform 3

Status: VALIDATED

Source sequence(s)

AC154257, AC154328

Consensus CDS

CCDS88521.1

UniProtKB/TrEMBL

E0CZ72, F8VQ42

Related

ENSMUSP00000125644.2, ENSMUST00000159772.8

Conserved Domains (1) summary

cd01367
Location:222 → 550

KISc_KIF2_like; Kinesin motor domain, KIF2-like group
NM_001378936.1 → NP_001365865.1 kinesin-like protein KIF2A isoform 4

Status: VALIDATED

Source sequence(s)

AC154257, AC154328

UniProtKB/TrEMBL

F8VQ42

Related

ENSMUSP00000113921.3, ENSMUST00000117423.9

Conserved Domains (1) summary

cd01367
Location:176 → 504

KISc_KIF2_like; Kinesin motor domain, KIF2-like group
NM_001378937.1 → NP_001365866.1 kinesin-like protein KIF2A isoform 5

Status: VALIDATED

Source sequence(s)

AC154257, AC154328

UniProtKB/TrEMBL

F8VQ42

Conserved Domains (1) summary

cd01367
Location:203 → 531

KISc_KIF2_like; Kinesin motor domain, KIF2-like group
NM_001378938.1 → NP_001365867.1 kinesin-like protein KIF2A isoform 6

Status: VALIDATED

Source sequence(s)

AC154257, AC154328

UniProtKB/TrEMBL

F8VQ42

Conserved Domains (1) summary

cd01367
Location:203 → 531

KISc_KIF2_like; Kinesin motor domain, KIF2-like group
NM_001378939.1 → NP_001365868.1 kinesin-like protein KIF2A isoform 7

Status: VALIDATED

Source sequence(s)

AC154257, AC154328

UniProtKB/TrEMBL

F8VQ42

Conserved Domains (1) summary

cd01367
Location:195 → 523

KISc_KIF2_like; Kinesin motor domain, KIF2-like group
NM_001378940.1 → NP_001365869.1 kinesin-like protein KIF2A isoform 8

Status: VALIDATED

Source sequence(s)

AC154257, AC154328

UniProtKB/TrEMBL

F8VQ42

Related

ENSMUSP00000113361.2, ENSMUST00000117539.8

Conserved Domains (1) summary

cd01367
Location:203 → 531

KISc_KIF2_like; Kinesin motor domain, KIF2-like group
NM_008442.2 → NP_032468.2 kinesin-like protein KIF2A isoform 1

See identical proteins and their annotated locations for NP_032468.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).

Source sequence(s)

AC154257, AC154328, AK016720, AK037037, BB622253, BE863830, CF581603

Consensus CDS

CCDS26759.1

UniProtKB/TrEMBL

F8VQ42

Related

ENSMUSP00000112715.2, ENSMUST00000122233.8

Conserved Domains (2) summary

smart00129
Location:195 → 531

KISc; Kinesin motor, catalytic domain. ATPase

cd01367
Location:195 → 523

KISc_KIF2_like; Kinesin motor domain, KIF2-like group

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

107095504..107158931 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036157877.1 → XP_036013770.1 kinesin-like protein KIF2A isoform X1

UniProtKB/TrEMBL

F8VQ42

Conserved Domains (1) summary

cd01367
Location:176 → 504

KISc_KIF2_like; Kinesin motor domain, KIF2-like group
XM_036157878.1 → XP_036013771.1 kinesin-like protein KIF2A isoform X2

Conserved Domains (1) summary

cd01367
Location:222 → 536

KISc_KIF2_like; Kinesin motor domain, KIF2-like group