Kif1a kinesin family member 1A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kif1aprovided by MGI
Official Full Name: kinesin family member 1Aprovided by MGI
Primary source: MGI:MGI:108391
See related: Ensembl:ENSMUSG00000014602 AllianceGenome:MGI:108391
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ATSV; Kns1; Gm1626; C630002N23Rik
Summary: Enables microtubule binding activity. Predicted to be involved in several processes, including interkinetic nuclear migration; regulation of dendritic spine morphogenesis; and transport along microtubule. Located in neuron projection and neuronal cell body. Is expressed in nervous system; sensory organ; testis; and urinary system. Used to study hereditary spastic paraplegia 30. Human ortholog(s) of this gene implicated in NESCAV syndrome; hereditary sensory neuropathy; hereditary sensory neuropathy type 2C; hereditary spastic paraplegia; and hereditary spastic paraplegia 30. Orthologous to human KIF1A (kinesin family member 1A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cortex adult (RPKM 79.2), frontal lobe adult (RPKM 72.1) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 D; 1 46.74 cM

Exon count:: 51

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (92943180..93029760, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (93015455..93102039, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Huntingtin recruits KIF1A to transport synaptic vesicle precursors along the mouse axon to support synaptic transmission and motor skill learning.
Title: Huntingtin recruits KIF1A to transport synaptic vesicle precursors along the mouse axon to support synaptic transmission and motor skill learning.
Lattice light-sheet microscopy and evaluation of dendritic transport in cultured hippocampal tissue reveal high variability in mobility of the KIF1A motor domain and entry into dendritic spines.
Title: Lattice light-sheet microscopy and evaluation of dendritic transport in cultured hippocampal tissue reveal high variability in mobility of the KIF1A motor domain and entry into dendritic spines.
Association of variants in the KIF1A gene with amyotrophic lateral sclerosis.
Title: Association of variants in the KIF1A gene with amyotrophic lateral sclerosis.
GSK3beta Impairs KIF1A Transport in a Cellular Model of Alzheimer's Disease but Does Not Regulate Motor Motility at S402.
Title: GSK3β Impairs KIF1A Transport in a Cellular Model of Alzheimer's Disease but Does Not Regulate Motor Motility at S402.
these findings support a primary role for KIF1A in the anterograde transport of BACE1.
Title: KIF1A mediates axonal transport of BACE1 and identification of independently moving cargoes in living SCG neurons.
propose that KIF1A is essential for the survival and function of sensory neurons.
Title: The Molecular Motor KIF1A Transports the TrkA Neurotrophin Receptor and Is Essential for Sensory Neuron Survival and Function.
The Doublecortin specifically enhances binding of the ADP-bound Kif1a motor domain to microtubules. Dcx is essential for the function of Kif1a, a kinesin-3 motor protein that traffics synaptic vesicles.
Title: Molecular basis for specific regulation of neuronal kinesin-3 motors by doublecortin family proteins.
This study demonstrated that KIF1A is indispensable for BDNF-mediated hippocampal synaptogenesis and learning enhancement induced by enrichment.
Title: Motor protein KIF1A is essential for hippocampal synaptogenesis and learning enhancement in an enriched environment.
The KIF1A-microtubule binding free energy is dominated by van der Waals interactions and electrostatic interactions.
Title: Probing the structural and energetic basis of kinesin-microtubule binding using computational alanine-scanning mutagenesis.
propose a model mechanism for microtubule activation of Mg-ADP release from KIF1A
Title: Structural model for strain-dependent microtubule activation of Mg-ADP release from kinesin.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (2)
Gene trapped (1)
Targeted (3) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D29951 (e-PCR)
- UniSTS:124822

D29951 (e-PCR)
- UniSTS:163258

RH139334 (e-PCR)
- UniSTS:221420

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables plus-end-directed microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in anterograde axonal transport	ISO Inferred from Sequence Orthology more info
involved_in anterograde neuronal dense core vesicle transport	ISO Inferred from Sequence Orthology more info
involved_in anterograde synaptic vesicle transport	IDA Inferred from Direct Assay more info	PubMed
involved_in cytoskeleton-dependent intracellular transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in dense core granule cytoskeletal transport	ISO Inferred from Sequence Orthology more info
involved_in interkinetic nuclear migration	ISO Inferred from Sequence Orthology more info
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport along microtubule	ISO Inferred from Sequence Orthology more info
involved_in regulation of dendritic spine development	ISO Inferred from Sequence Orthology more info
involved_in regulation of dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in retrograde neuronal dense core vesicle transport	ISO Inferred from Sequence Orthology more info
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in neuronal dense core vesicle	ISO Inferred from Sequence Orthology more info
located_in postsynapse	ISO Inferred from Sequence Orthology more info
located_in presynapse	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: kinesin-like protein KIF1A

Names: N-3 kinesin; axonal transporter of synaptic vesicles; kinesin heavy chain member 1A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110315.3 → NP_001103785.1 kinesin-like protein KIF1A isoform b

Status: VALIDATED

Source sequence(s)

AC110247, AC119846

Consensus CDS

CCDS48326.1

UniProtKB/TrEMBL

E9QAN4, Q6P5H4

Related

ENSMUSP00000130717.2, ENSMUST00000171556.8

Conserved Domains (7) summary

cd00060
Location:492 → 596

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01233
Location:1570 → 1672

PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain

cd01365
Location:4 → 361

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam04502
Location:598 → 676

DUF572; Family of unknown function (DUF572)

pfam12423
Location:805 → 851

KIF1B; Kinesin protein 1B

pfam12473
Location:1148 → 1295

DUF3694; Kinesin protein

pfam16183
Location:358 → 515

Kinesin_assoc; Kinesin-associated
NM_001294149.2 → NP_001281078.1 kinesin-like protein KIF1A isoform c

Status: VALIDATED

Source sequence(s)

AC110247, AC119846

Consensus CDS

CCDS78651.1

UniProtKB/TrEMBL

E9Q9G6, Q3UH16

Related

ENSMUSP00000108582.3, ENSMUST00000112958.9

Conserved Domains (7) summary

cd00060
Location:492 → 596

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01233
Location:1579 → 1681

PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain

cd01365
Location:4 → 361

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam04502
Location:598 → 676

DUF572; Family of unknown function (DUF572)

pfam12423
Location:805 → 851

KIF1B; Kinesin protein 1B

pfam12473
Location:1148 → 1304

DUF3694; Kinesin protein

pfam16183
Location:358 → 515

Kinesin_assoc; Kinesin-associated
NM_001294150.2 → NP_001281079.1 kinesin-like protein KIF1A isoform d

See identical proteins and their annotated locations for NP_001281079.1

Status: VALIDATED

Source sequence(s)

AC110247, AC119846

Consensus CDS

CCDS78652.1

UniProtKB/TrEMBL

Q6P5H4, Q6TA13

Related

ENSMUSP00000084029.6, ENSMUST00000086819.12

Conserved Domains (7) summary

cd00060
Location:501 → 605

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01233
Location:1579 → 1681

PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain

cd01365
Location:4 → 361

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam04502
Location:607 → 685

DUF572; Family of unknown function (DUF572)

pfam12423
Location:814 → 860

KIF1B; Kinesin protein 1B

pfam12473
Location:1157 → 1304

DUF3694; Kinesin protein

pfam16183
Location:358 → 524

Kinesin_assoc; Kinesin-associated
NM_001368847.2 → NP_001355776.1 kinesin-like protein KIF1A isoform e

Status: VALIDATED

Source sequence(s)

AC110247, AC119846

UniProtKB/Swiss-Prot

P33173, Q61770

Conserved Domains (7) summary

cd00060
Location:501 → 605

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01233
Location:1587 → 1689

PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain

cd01365
Location:4 → 361

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam04502
Location:607 → 685

DUF572; Family of unknown function (DUF572)

pfam12423
Location:814 → 860

KIF1B; Kinesin protein 1B

pfam12473
Location:1157 → 1312

DUF3694; Kinesin protein

pfam16183
Location:358 → 524

Kinesin_assoc; Kinesin-associated
NM_001408925.1 → NP_001395854.1 kinesin-like protein KIF1A isoform f

Status: VALIDATED

Source sequence(s)

AC110247, AC119846

UniProtKB/TrEMBL

A0A087WQE8

Related

ENSMUSP00000140163.2, ENSMUST00000190723.7
NM_008440.5 → NP_032466.2 kinesin-like protein KIF1A isoform a

See identical proteins and their annotated locations for NP_032466.2

Status: VALIDATED

Source sequence(s)

AC110247, AC119846

Consensus CDS

CCDS48327.1

UniProtKB/Swiss-Prot

P33173, Q61770

UniProtKB/TrEMBL

G3UW47

Related

ENSMUSP00000128432.2, ENSMUST00000171796.8

Conserved Domains (7) summary

cd00060
Location:492 → 596

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01233
Location:1578 → 1680

PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain

cd01365
Location:4 → 361

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam04502
Location:598 → 676

DUF572; Family of unknown function (DUF572)

pfam12423
Location:805 → 851

KIF1B; Kinesin protein 1B

pfam12473
Location:1148 → 1303

DUF3694; Kinesin protein

pfam16183
Location:358 → 515

Kinesin_assoc; Kinesin-associated

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

92943180..93029760 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006529155.5 → XP_006529218.1 kinesin-like protein KIF1A isoform X1

UniProtKB/TrEMBL

Q3UH16

Conserved Domains (7) summary

cd00060
Location:501 → 605

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01233
Location:1681 → 1783

PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain

cd01365
Location:4 → 361

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam04502
Location:607 → 685

DUF572; Family of unknown function (DUF572)

pfam12423
Location:814 → 861

KIF1B; Kinesin protein 1B

pfam12473
Location:1250 → 1406

DUF3694; Kinesin protein

pfam16183
Location:358 → 524

Kinesin_assoc; Kinesin-associated
XM_036162306.1 → XP_036018199.1 kinesin-like protein KIF1A isoform X6

UniProtKB/TrEMBL

Q3UH16

Conserved Domains (6) summary

cd00060
Location:492 → 596

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01233
Location:1664 → 1766

PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain

cd01365
Location:4 → 361

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam12423
Location:805 → 852

KIF1B; Kinesin protein 1B

pfam12473
Location:1233 → 1389

DUF3694; Kinesin protein

pfam16183
Location:358 → 515

Kinesin_assoc; Kinesin-associated
XM_036162307.1 → XP_036018200.1 kinesin-like protein KIF1A isoform X7

UniProtKB/TrEMBL

Q6P5H4

Conserved Domains (6) summary

cd00060
Location:492 → 596

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01233
Location:1663 → 1765

PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain

cd01365
Location:4 → 361

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam12423
Location:805 → 852

KIF1B; Kinesin protein 1B

pfam12473
Location:1241 → 1388

DUF3694; Kinesin protein

pfam16183
Location:358 → 515

Kinesin_assoc; Kinesin-associated
XM_006529159.5 → XP_006529222.1 kinesin-like protein KIF1A isoform X5

UniProtKB/TrEMBL

Q3UH16

Conserved Domains (7) summary

cd00060
Location:492 → 596

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01233
Location:1672 → 1774

PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain

cd01365
Location:4 → 361

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam04502
Location:598 → 676

DUF572; Family of unknown function (DUF572)

pfam12423
Location:805 → 852

KIF1B; Kinesin protein 1B

pfam12473
Location:1241 → 1397

DUF3694; Kinesin protein

pfam16183
Location:358 → 515

Kinesin_assoc; Kinesin-associated
XM_006529160.5 → XP_006529223.1 kinesin-like protein KIF1A isoform X8

UniProtKB/TrEMBL

Q3UH16

Conserved Domains (7) summary

cd00060
Location:501 → 605

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01233
Location:1588 → 1690

PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain

cd01365
Location:4 → 361

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam04502
Location:607 → 685

DUF572; Family of unknown function (DUF572)

pfam12423
Location:814 → 860

KIF1B; Kinesin protein 1B

pfam12473
Location:1157 → 1313

DUF3694; Kinesin protein

pfam16183
Location:358 → 524

Kinesin_assoc; Kinesin-associated
XM_006529157.5 → XP_006529220.1 kinesin-like protein KIF1A isoform X3

UniProtKB/TrEMBL

Q3UH16

Conserved Domains (7) summary

cd00060
Location:501 → 605

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01233
Location:1673 → 1775

PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain

cd01365
Location:4 → 361

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam04502
Location:607 → 685

DUF572; Family of unknown function (DUF572)

pfam12423
Location:814 → 861

KIF1B; Kinesin protein 1B

pfam12473
Location:1242 → 1398

DUF3694; Kinesin protein

pfam16183
Location:358 → 524

Kinesin_assoc; Kinesin-associated
XM_006529156.5 → XP_006529219.1 kinesin-like protein KIF1A isoform X2

UniProtKB/Swiss-Prot

P33173, Q61770

Conserved Domains (7) summary

cd00060
Location:501 → 605

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01233
Location:1680 → 1782

PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain

cd01365
Location:4 → 361

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam04502
Location:607 → 685

DUF572; Family of unknown function (DUF572)

pfam12423
Location:814 → 861

KIF1B; Kinesin protein 1B

pfam12473
Location:1250 → 1405

DUF3694; Kinesin protein

pfam16183
Location:358 → 524

Kinesin_assoc; Kinesin-associated