Kif16b kinesin family member 16B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kif16bprovided by MGI
Official Full Name: kinesin family member 16Bprovided by MGI
Primary source: MGI:MGI:1098240
See related: Ensembl:ENSMUSG00000038844 AllianceGenome:MGI:1098240
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA1590; 8430434E15Rik
Summary: Enables small GTPase binding activity. Involved in several processes, including Golgi to endosome transport; endoderm development; and fibroblast growth factor receptor signaling pathway. Acts upstream of or within cellular response to interferon-gamma. Located in phagocytic vesicle. Orthologous to human KIF16B (kinesin family member 16B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in genital fat pad adult (RPKM 2.8), kidney adult (RPKM 2.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 G1; 2 70.67 cM

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (142459399..142743535, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (142618340..142901609, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the stalk domain of kinesin superfamily protein 16B determines the specific somatodendritic localization of Endosomes mediated by a novel intramolecular inhibitory mechanism.
Title: Characterizing KIF16B in neurons reveals a novel intramolecular "stalk inhibition" mechanism that regulates its capacity to potentiate the selective somatodendritic localization of early endosomes.
The kinesin-3 motor KIF16B/Rab14 complex acts in biosynthetic Golgi-to-endosome traffic of the fibroblast growth factor receptor (FGFR) during early embryonic development.
Title: KIF16B/Rab14 molecular motor complex is critical for early embryonic development by transporting FGF receptor.
The most salient structural feature of KIF16B-PX is that two neighboring residues, L1248 and F1249, on the membrane-binding surface form a protruding hydrophobic stalk with a large solvent-accessible surface area
Title: The structural basis of novel endosome anchoring activity of KIF16B kinesin.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:234543

RH126836 (e-PCR)
- UniSTS:207412

D2Mit21 (e-PCR), detects polymorphism
- UniSTS:129083

D2Mit259 (e-PCR), detects polymorphism
- UniSTS:129140

Results_ER_9_6_95_62.seq (e-PCR)
- UniSTS:125613

RH130395 (e-PCR)
- UniSTS:213679

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,4-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3-phosphate binding	ISO Inferred from Sequence Orthology more info
enables plus-end-directed microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables plus-end-directed microtubule motor activity	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi to endosome transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to type II interferon	IDA Inferred from Direct Assay more info	PubMed
involved_in early endosome to late endosome transport	ISO Inferred from Sequence Orthology more info
involved_in endoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in fibroblast growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in formation of primary germ layer	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor catabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of receptor recycling	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in endosome	ISO Inferred from Sequence Orthology more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in phagocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in spindle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: kinesin-like protein KIF16B

Names: N-3 kinesin; kinesin 16B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081133.3 → NP_001074602.1 kinesin-like protein KIF16B isoform 2

See identical proteins and their annotated locations for NP_001074602.1

Status: VALIDATED

Source sequence(s)

AL731712, AL731790, AL929136

Consensus CDS

CCDS38251.1

UniProtKB/Swiss-Prot

B1AVY7, O35056, Q3TUD2, Q6ZPM0, Q8BZZ9

UniProtKB/TrEMBL

A0A1D5RMD4

Related

ENSMUSP00000042551.8, ENSMUST00000043589.8

Conserved Domains (6) summary

cd06874
Location:1179 → 1306

PX_KIF16B_SNX23; The phosphoinositide binding Phox Homology domain of KIF16B kinesin or Sorting Nexin 23

smart00129
Location:3 → 365

KISc; Kinesin motor, catalytic domain. ATPase

cd01365
Location:2 → 365

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam00498
Location:478 → 543

FHA; FHA domain

pfam16183
Location:364 → 476

Kinesin_assoc; Kinesin-associated

cl23765
Location:602 → 724

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
NM_001355123.2 → NP_001342052.1 kinesin-like protein KIF16B isoform 1

Status: VALIDATED

Source sequence(s)

AL731712, AL731790, AL929136

Consensus CDS

CCDS89559.1

UniProtKB/TrEMBL

A0A1D5RMD4, E7FLY0

Related

ENSMUSP00000154926.2, ENSMUST00000230763.2

Conserved Domains (5) summary

cd06874
Location:1190 → 1317

PX_KIF16B_SNX23; The phosphoinositide binding Phox Homology domain of KIF16B kinesin or Sorting Nexin 23

cd01365
Location:2 → 365

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam00498
Location:478 → 543

FHA; FHA domain

pfam16183
Location:364 → 476

Kinesin_assoc; Kinesin-associated

cl25732
Location:613 → 867

SMC_N; RecF/RecN/SMC N terminal domain
NM_001421415.1 → NP_001408344.1 kinesin-like protein KIF16B isoform 3

Status: VALIDATED

Source sequence(s)

AL731712, AL929136
NM_001421416.1 → NP_001408345.1 kinesin-like protein KIF16B isoform 4

Status: VALIDATED

Source sequence(s)

AL731712, AL929136
NM_001421417.1 → NP_001408346.1 kinesin-like protein KIF16B isoform 5

Status: VALIDATED

Source sequence(s)

AL731712, AL731790, AL929136
NM_001421418.1 → NP_001408347.1 kinesin-like protein KIF16B isoform 6

Status: VALIDATED

Source sequence(s)

AL731712, AL731790, AL929136
NM_001421419.1 → NP_001408348.1 kinesin-like protein KIF16B isoform 7

Status: VALIDATED

Source sequence(s)

AL731712, AL731790, AL929136

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

142459399..142743535 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158820.1 → XP_036014713.1 kinesin-like protein KIF16B isoform X10

UniProtKB/TrEMBL

A0A1D5RMD4

Conserved Domains (6) summary

cd06874
Location:1162 → 1265

PX_KIF16B_SNX23; The phosphoinositide binding Phox Homology domain of KIF16B kinesin or Sorting Nexin 23

COG1196
Location:602 → 856

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:759 → 1073

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd01365
Location:2 → 365

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam00498
Location:478 → 543

FHA; FHA domain

pfam16183
Location:364 → 476

Kinesin_assoc; Kinesin-associated
XM_036158819.1 → XP_036014712.1 kinesin-like protein KIF16B isoform X9

Conserved Domains (6) summary

cd06874
Location:1162 → 1289

PX_KIF16B_SNX23; The phosphoinositide binding Phox Homology domain of KIF16B kinesin or Sorting Nexin 23

COG0419
Location:631 → 1163

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

COG1196
Location:636 → 890

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01365
Location:51 → 399

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam00498
Location:512 → 577

FHA; FHA domain

pfam16183
Location:398 → 510

Kinesin_assoc; Kinesin-associated
XM_036158817.1 → XP_036014710.1 kinesin-like protein KIF16B isoform X8

UniProtKB/TrEMBL

A0A1D5RMD4

Conserved Domains (5) summary

cd06874
Location:1207 → 1310

PX_KIF16B_SNX23; The phosphoinositide binding Phox Homology domain of KIF16B kinesin or Sorting Nexin 23

COG0419
Location:644 → 1081

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd01365
Location:51 → 399

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam00498
Location:512 → 577

FHA; FHA domain

pfam16183
Location:398 → 510

Kinesin_assoc; Kinesin-associated
XM_036158812.1 → XP_036014705.1 kinesin-like protein KIF16B isoform X5

Conserved Domains (4) summary

COG0419
Location:642 → 1145

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd01365
Location:51 → 399

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam00498
Location:512 → 577

FHA; FHA domain

pfam16183
Location:398 → 510

Kinesin_assoc; Kinesin-associated
XM_036158800.1 → XP_036014693.1 kinesin-like protein KIF16B isoform X1

Conserved Domains (4) summary

COG0419
Location:644 → 1081

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd01365
Location:51 → 399

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam00498
Location:512 → 577

FHA; FHA domain

pfam16183
Location:398 → 510

Kinesin_assoc; Kinesin-associated
XM_036158804.1 → XP_036014697.1 kinesin-like protein KIF16B isoform X2

Conserved Domains (4) summary

COG0419
Location:633 → 1070

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd01365
Location:51 → 399

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam00498
Location:512 → 577

FHA; FHA domain

pfam16183
Location:398 → 510

Kinesin_assoc; Kinesin-associated