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    Kera keratocan [ Mus musculus (house mouse) ]

    Gene ID: 16545, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Keraprovided by MGI
    Official Full Name
    keratocanprovided by MGI
    Primary source
    MGI:MGI:1202398
    See related
    Ensembl:ENSMUSG00000019932 AllianceGenome:MGI:1202398
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KTN; CNA2; SLRR2B
    Summary
    Acts upstream of or within cornea development in camera-type eye. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including central nervous system; cranial muscle; jaw; limb mesenchyme; and sensory organ. Used to study cornea plana. Human ortholog(s) of this gene implicated in arcus senilis; cornea plana; and corneal dystrophy. Orthologous to human KERA (keratocan). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward limb E14.5 (RPKM 43.4) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 C3; 10 50.34 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (97442873..97449555)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (97606962..97613688)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930473O22 gene Neighboring gene lumican Neighboring gene predicted gene, 40749 Neighboring gene epiphycan Neighboring gene predicted gene 10754

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Keratocan is expressed by osteoblasts and can modulate osteogenic differentiation. Igwe JC, et al. Connect Tissue Res, 2011 Oct. PMID 21405980, Free PMC Article
    2. An X-ray scattering investigation of corneal structure in keratocan-deficient mice. Meek KM, et al. Matrix Biol, 2003 Nov. PMID 14667839
    3. Keratocan-deficient mice display alterations in corneal structure. Liu CY, et al. J Biol Chem, 2003 Jun 13. PMID 12665512
    4. The cloning of mouse keratocan cDNA and genomic DNA and the characterization of its expression during eye development. Liu CY, et al. J Biol Chem, 1998 Aug 28. PMID 9712886
    5. Excess Transforming Growth Factor-α Changed the Cell Properties of Corneal Epithelium and Stroma. Zhang L, et al. Invest Ophthalmol Vis Sci, 2020 Jul 1. PMID 32668000, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Stromal matrix directs corneal fibroblasts to re-express keratocan after injury and transplantation.
      Title: Stromal matrix directs corneal fibroblasts to re-express keratocan after injury and transplantation.
    2. rare variant in KERA was identified in a large kindred with premature atherosclerosis
      Title: Mutation in KERA identified by linkage analysis and targeted resequencing in a pedigree with premature atherosclerosis.
    3. our results demonstrate the expression of keratocan by osteoblast lineage cells and its ability to modulate osteoblast function.
      Title: Keratocan is expressed by osteoblasts and can modulate osteogenic differentiation.
    4. lumican and keratocan core proteins bind the CXC chemokine KC during a corneal inflammatory response, indicating that corneal KSPGs mediate neutrophil recruitment to the cornea by regulating chemokine gradient formation.
      Title: Keratocan and lumican regulate neutrophil infiltration and corneal clarity in lipopolysaccharide-induced keratitis by direct interaction with CXCL1.
    5. Keratocan-deficient mice have corneal collagen fibrils with significantly larger diameters than those in wild-type mice, and increased centre-to-centre spacing of the fibrils.
      Title: An X-ray scattering investigation of corneal structure in keratocan-deficient mice.
    6. Keratocan plays a unique role in maintaining the appropriate corneal shape to ensure normal vision
      Title: Keratocan-deficient mice display alterations in corneal structure.
    7. lumican has a novel regulatory role in keratocan expression at the transcriptional level
      Title: Keratocan, a cornea-specific keratan sulfate proteoglycan, is regulated by lumican.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within cornea development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    keratocan
    Names
    keratan sulfate proteoglycan keratocan

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008438.3 → NP_032464.1  keratocan precursor

      See identical proteins and their annotated locations for NP_032464.1

      Status: VALIDATED

      Source sequence(s)
      AC159710
      Consensus CDS
      CCDS36044.1
      UniProtKB/Swiss-Prot
      O35367
      UniProtKB/TrEMBL
      A4FUJ3, Q8C3D9
      Related
      ENSMUSP00000100923.3, ENSMUST00000105286.4
      Conserved Domains (3) summary
      PRK15370
      Location:16 → 298
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      sd00033
      Location:74 → 97
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:268 → 331
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      97442873..97449555
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513273.5 → XP_006513336.1  keratocan isoform X1

      See identical proteins and their annotated locations for XP_006513336.1

      UniProtKB/Swiss-Prot
      O35367
      UniProtKB/TrEMBL
      A4FUJ3, Q8C3D9
      Conserved Domains (3) summary
      PRK15370
      Location:16 → 298
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      sd00033
      Location:74 → 97
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:268 → 331
      LRR_8; Leucine rich repeat
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35367.1 GenPept UniProtKB/Swiss-Prot:O35367

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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