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    Kcns2 K+ voltage-gated channel, subfamily S, 2 [ Mus musculus (house mouse) ]

    Gene ID: 16539, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Kcns2provided by MGI
    Official Full Name
    K+ voltage-gated channel, subfamily S, 2provided by MGI
    Primary source
    MGI:MGI:1197011
    See related
    Ensembl:ENSMUSG00000050963 AllianceGenome:MGI:1197011
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kv9.2; E130006J24Rik
    Summary
    Predicted to enable voltage-gated potassium channel activity. Involved in potassium ion transport and regulation of delayed rectifier potassium channel activity. Located in perinuclear region of cytoplasm and plasma membrane. Part of voltage-gated potassium channel complex. Is expressed in diencephalon lateral wall mantle layer; heart; and olfactory epithelium. Orthologous to human KCNS2 (potassium voltage-gated channel modifier subfamily S member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cortex adult (RPKM 2.7), frontal lobe adult (RPKM 2.6) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 B3.1; 15 14.34 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (34837501..34843553)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (34837355..34843407)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53873 Neighboring gene predicted gene, 53874 Neighboring gene predicted gene, 32970 Neighboring gene predicted gene, 53875 Neighboring gene STARR-seq mESC enhancer starr_38332 Neighboring gene STARR-seq mESC enhancer starr_38333 Neighboring gene STARR-seq mESC enhancer starr_38334 Neighboring gene STARR-seq mESC enhancer starr_38335 Neighboring gene STARR-seq mESC enhancer starr_38336 Neighboring gene serine/threonine kinase 3 Neighboring gene predicted gene, 52204 Neighboring gene STARR-seq mESC enhancer starr_38337 Neighboring gene STARR-seq mESC enhancer starr_38338 Neighboring gene predicted gene, 52178 Neighboring gene predicted gene, 33497

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. New modulatory alpha subunits for mammalian Shab K+ channels. Salinas M, et al. J Biol Chem, 1997 Sep 26. PMID 9305895
    2. Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development. Harrell MD, et al. Physiol Genomics, 2007 Feb 12. PMID 16985003
    3. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of delayed rectifier potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    potassium voltage-gated channel subfamily S member 2
    Names
    delayed-rectifier K(+) channel alpha subunit 2
    voltage-gated potassium channel subunit Kv9.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271704.1 → NP_001258633.1  potassium voltage-gated channel subfamily S member 2

      See identical proteins and their annotated locations for NP_001258633.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK039387, AK050926, BC059833, BE954026
      Consensus CDS
      CCDS27421.1
      UniProtKB/Swiss-Prot
      O35174, Q543P3
      UniProtKB/TrEMBL
      Q69ZQ8
      Related
      ENSMUSP00000153984.2, ENSMUST00000228725.2
      Conserved Domains (2) summary
      pfam00520
      Location:186 → 421
      Ion_trans; Ion transport protein
      pfam02214
      Location:19 → 118
      BTB_2; BTB/POZ domain

    2. NM_181317.4 → NP_851834.1  potassium voltage-gated channel subfamily S member 2

      See identical proteins and their annotated locations for NP_851834.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK050926, AK173110, BE954026
      Consensus CDS
      CCDS27421.1
      UniProtKB/Swiss-Prot
      O35174, Q543P3
      UniProtKB/TrEMBL
      Q69ZQ8
      Related
      ENSMUSP00000072645.4, ENSMUST00000072868.5
      Conserved Domains (2) summary
      pfam00520
      Location:186 → 421
      Ion_trans; Ion transport protein
      pfam02214
      Location:19 → 118
      BTB_2; BTB/POZ domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      34837501..34843553
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_008436.1: Suppressed sequence

      Description
      NM_008436.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35174.1 GenPept UniProtKB/Swiss-Prot:O35174

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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