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    Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 [ Mus musculus (house mouse) ]

    Gene ID: 16522, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Kcnj6provided by MGI
    Official Full Name
    potassium inwardly-rectifying channel, subfamily J, member 6provided by MGI
    Primary source
    MGI:MGI:104781
    See related
    Ensembl:ENSMUSG00000043301 AllianceGenome:MGI:104781
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    wv; BIR1; GIRK2; KATP2; KCNJ7; Kir3.2; weaver
    Summary
    Enables G-protein activated inward rectifier potassium channel activity. Acts upstream of or within thyroid hormone metabolic process. Located in parallel fiber to Purkinje cell synapse. Is integral component of presynaptic membrane. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and skeleton. Human ortholog(s) of this gene implicated in alcohol use disorder and heroin dependence. Orthologous to human KCNJ6 (potassium inwardly rectifying channel subfamily J member 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cortex adult (RPKM 1.9), testis adult (RPKM 1.8) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    16 C4; 16 55.44 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (94545839..94798719, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (94744980..94997696, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41504 Neighboring gene predicted gene, 41505 Neighboring gene predicted gene, 41507 Neighboring gene STARR-seq mESC enhancer starr_41586 Neighboring gene STARR-seq mESC enhancer starr_41589 Neighboring gene STARR-seq mESC enhancer starr_41593 Neighboring gene STARR-seq mESC enhancer starr_41595 Neighboring gene predicted gene, 31407 Neighboring gene STARR-seq mESC enhancer starr_41597 Neighboring gene STARR-seq mESC enhancer starr_41598 Neighboring gene 60S ribosomal protein L7a pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel ion conducting route besides the central pore in an inherited mutant of G-protein-gated inwardly rectifying K(+) channel. Chen IS, et al. J Physiol, 2022 Feb. PMID 34881429
    2. The Expression and Localisation of G-Protein-Coupled Inwardly Rectifying Potassium (GIRK) Channels Is Differentially Altered in the Hippocampus of Two Mouse Models of Alzheimer's Disease. Alfaro-Ruiz R, et al. Int J Mol Sci, 2021 Oct 14. PMID 34681766, Free PMC Article
    3. Beta-Cell Ion Channels and Their Role in Regulating Insulin Secretion. Thompson B, et al. Compr Physiol, 2021 Oct 12. PMID 34636409, Free PMC Article
    4. Insight into the Selectivity of Kir3.2 toward Phosphatidylinositides. Qiao P, et al. Biochemistry, 2020 Jun 9. PMID 32372643
    5. Selective binding of a toxin and phosphatidylinositides to a mammalian potassium channel. Liu Y, et al. Nat Commun, 2019 Mar 22. PMID 30902995, Free PMC Article

    See all (332) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GIRK2 potassium channels expressed by the AgRP neurons decrease adiposity and body weight in mice.
      Title: GIRK2 potassium channels expressed by the AgRP neurons decrease adiposity and body weight in mice.
    2. A novel ion conducting route besides the central pore in an inherited mutant of G-protein-gated inwardly rectifying K(+) channel.
      Title: A novel ion conducting route besides the central pore in an inherited mutant of G-protein-gated inwardly rectifying K(+) channel.
    3. The Expression and Localisation of G-Protein-Coupled Inwardly Rectifying Potassium (GIRK) Channels Is Differentially Altered in the Hippocampus of Two Mouse Models of Alzheimer's Disease.
      Title: The Expression and Localisation of G-Protein-Coupled Inwardly Rectifying Potassium (GIRK) Channels Is Differentially Altered in the Hippocampus of Two Mouse Models of Alzheimer's Disease.
    4. Insight into the Selectivity of Kir3.2 toward Phosphatidylinositides.
      Title: Insight into the Selectivity of Kir3.2 toward Phosphatidylinositides.
    5. These results reveal selective small molecule binding and uncover a mechanism by which rotation of the cytoplasmic domain can modulate GIRK*phosphatidylinositide interactions.
      Title: Selective binding of a toxin and phosphatidylinositides to a mammalian potassium channel.
    6. The results of this study indicated that Kcnj6 triploid mice show an increase in GIRK2 protein levels compared to WT mice in the cortex and thalamus.
      Title: Kcnj6(GIRK2) trisomy is not sufficient for conferring the susceptibility to infantile spasms seen in the Ts65Dn mouse model of down syndrome.
    7. GIRK2 isoform balance within a neuron can impact the processing of afferent inhibitory input and associated behavior.
      Title: GIRK2 splice variants and neuronal G protein-gated K(+) channels: implications for channel function and behavior.
    8. Locomotor activity of the mice was not changed compared to that of GIRK2(floxed) mice, when tested in the open field
      Title: Deletion of GIRK2 subunit containing GIRK channels of neurons expressing dopamine transporter decrease immobility time on forced swimming in mice.
    9. Results indicate that the properties and inhibitory activity of dorsal raphe neurons are highly regulated by G protein-coupled inwardly rectifying K+ (GIRK) 2 subunit-containing channels, introducing GIRK channels as potential candidates for studying the pathophysiology and treatment of affective disorders.
      Title: Inactivation of GIRK channels weakens the pre- and postsynaptic inhibitory activity in dorsal raphe neurons.
    10. Increased Kcnj6 gene dose is necessary for synaptic and cognitive dysfunction in the animal model of Down Syndrome.
      Title: Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome.
    Submit: New GeneRIF Correction See all GeneRIFs (47)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G-protein activated inward rectifier potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables G-protein alpha-subunit binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within monoatomic ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of insulin secretion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in potassium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of monoatomic ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of presynaptic membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within thyroid hormone metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		  
    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in parallel fiber to Purkinje cell synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    G protein-activated inward rectifier potassium channel 2
    Names
    G-protein-coupled inward rectifier K+ channel 2-1
    G-protein-coupled inward rectifier K+ channel 2-A
    G-protein-coupled inward rectifier K+ channel 2-B
    G-protein-coupled inward rectifier K+ channel 2-C
    GIRK-2
    inward rectifier K(+) channel Kir3.2
    potassium channel, inwardly rectifying subfamily J member 6
    potassium inwardly-rectifying channel J6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025584.2 → NP_001020755.1  G protein-activated inward rectifier potassium channel 2 isoform Girk2-1

      See identical proteins and their annotated locations for NP_001020755.1

      Status: VALIDATED

      Source sequence(s)
      AK081109, BB591362
      Consensus CDS
      CCDS37408.1
      UniProtKB/TrEMBL
      Q3UTV4, Q8C4T8
      Related
      ENSMUSP00000093558.5, ENSMUST00000095873.12
      Conserved Domains (2) summary
      pfam01007
      Location:59 → 198
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:205 → 374
      IRK_C; Inward rectifier potassium channel C-terminal domain

    2. NM_001025585.2 → NP_001020756.1  G protein-activated inward rectifier potassium channel 2 isoform Girk2B

      See identical proteins and their annotated locations for NP_001020756.1

      Status: VALIDATED

      Source sequence(s)
      BB277039, BB591362, D86040
      UniProtKB/TrEMBL
      Q8C8Y6
      Related
      ENSMUST00000232403.2
      Conserved Domains (1) summary
      cl21560
      Location:59 → 318
      Ion_trans_2; Ion channel

    3. NM_001025590.2 → NP_001020761.1  G protein-activated inward rectifier potassium channel 2 isoform Girk2C

      See identical proteins and their annotated locations for NP_001020761.1

      Status: VALIDATED

      Source sequence(s)
      AC165248
      Consensus CDS
      CCDS49921.1
      UniProtKB/TrEMBL
      A0A0R4J239, Q8C8Y6
      Related
      ENSMUSP00000130321.2, ENSMUST00000165538.3
      Conserved Domains (1) summary
      cl21560
      Location:41 → 302
      Ion_trans_2; Ion channel

    4. NM_010606.2 → NP_034736.2  G protein-activated inward rectifier potassium channel 2 isoform Girk2A-1

      See identical proteins and their annotated locations for NP_034736.2

      Status: VALIDATED

      Source sequence(s)
      AB029502, AC165271, AK044218, BB591362
      Consensus CDS
      CCDS37409.1
      UniProtKB/TrEMBL
      Q0VB45, Q3UTV4
      Related
      ENSMUSP00000097108.3, ENSMUST00000099508.4
      Conserved Domains (2) summary
      pfam01007
      Location:59 → 198
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:205 → 374
      IRK_C; Inward rectifier potassium channel C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      94545839..94798719 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246104.2 → XP_011244406.1  G protein-activated inward rectifier potassium channel 2 isoform X1

      See identical proteins and their annotated locations for XP_011244406.1

      UniProtKB/TrEMBL
      A0A338P6L0, Q3UTV4
      Related
      ENSMUSP00000156014.2, ENSMUST00000232562.2
      Conserved Domains (2) summary
      pfam01007
      Location:41 → 180
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:187 → 356
      IRK_C; Inward rectifier potassium channel C-terminal domain

    RNA

    1. XR_004939169.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48542.1 GenPept UniProtKB/Swiss-Prot:P48542

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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