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    Kcnj4 potassium inwardly-rectifying channel, subfamily J, member 4 [ Mus musculus (house mouse) ]

    Gene ID: 16520, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Kcnj4provided by MGI
    Official Full Name
    potassium inwardly-rectifying channel, subfamily J, member 4provided by MGI
    Primary source
    MGI:MGI:104743
    See related
    Ensembl:ENSMUSG00000044216 AllianceGenome:MGI:104743
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IRK3; Kcnf2; MB-IRK3
    Summary
    Predicted to enable PDZ domain binding activity and inward rectifier potassium channel activity. Predicted to be involved in potassium ion import across plasma membrane and regulation of ion transmembrane transport. Predicted to act upstream of or within potassium ion transport. Predicted to be located in basolateral plasma membrane; dendrite; and neuronal cell body. Predicted to be active in plasma membrane. Is expressed in several structures, including adrenal gland; alimentary system; epididymis; telencephalon; and thymus. Orthologous to human KCNJ4 (potassium inwardly rectifying channel subfamily J member 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in frontal lobe adult (RPKM 17.6) and cortex adult (RPKM 11.2) See more
    Orthologs
    human all
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    Genomic context

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    See Kcnj4 in Genome Data Viewer
    Location:
    15 E1; 15 37.74 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (79364427..79396712, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (79480226..79512511, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene casein kinase 1, epsilon Neighboring gene predicted gene 16059 Neighboring gene STARR-seq mESC enhancer starr_39185 Neighboring gene STARR-seq mESC enhancer starr_39186 Neighboring gene predicted gene, 41359 Neighboring gene STARR-seq mESC enhancer starr_39188 Neighboring gene KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 Neighboring gene STARR-seq mESC enhancer starr_39189 Neighboring gene DEAD box helicase 17 Neighboring gene DNA meiotic recombinase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Arachidonic acid activates Kir2.3 channels by enhancing channel-phosphatidyl-inositol 4,5-bisphosphate interactions. Wang C, et al. Mol Pharmacol, 2008 Apr. PMID 18202303
    2. Identification and molecular localization of a pH-sensing domain for the inward rectifier potassium channel HIR. Coulter KL, et al. Neuron, 1995 Nov. PMID 7576658
    3. Mechanical deformation of ventricular myocytes modulates both TRPC6 and Kir2.3 channels. Dyachenko V, et al. Cell Calcium, 2009 Jan. PMID 18635261
    4. Cholinergic modulation of Kir2 channels selectively elevates dendritic excitability in striatopallidal neurons. Shen W, et al. Nat Neurosci, 2007 Nov. PMID 17906621
    5. Heterogeneity of IK1 in the mouse heart. Panama BK, et al. Am J Physiol Heart Circ Physiol, 2007 Dec. PMID 17890431

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. modulated by mechanical deformation of ventricular myocytes
      Title: Mechanical deformation of ventricular myocytes modulates both TRPC6 and Kir2.3 channels.
    2. Enhanced interaction with PIP(2) is the molecular mechanism for Kir2.3 channel activation by arachidonic acid.
      Title: Arachidonic acid activates Kir2.3 channels by enhancing channel-phosphatidyl-inositol 4,5-bisphosphate interactions.
    3. Kir2.3 channels do not contribute to cardiac inward rectifier potassium currents.
      Title: Heterogeneity of IK1 in the mouse heart.
    4. K+ currents attributable to Kir2.2/2.3 and K+-selective leak (Kleak) channels are prominent in layer V-VI pyramidal neurons in slices of prelimbic and infralimbic cortex
      Title: Dendritic excitability of mouse frontal cortex pyramidal neurons is shaped by the interaction among HCN, Kir2, and Kleak channels.
    5. changes in these proteins and their modification may predispose striatal projection neurons to dysfunction and then degeneratation in Huntington disease
      Title: Neuronal vulnerability in mouse models of Huntington's disease: membrane channel protein changes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of monoatomic ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    inward rectifier potassium channel 4
    Names
    IRK-3
    Kir 2.3
    inward rectifier K(+) channel Kir2.3
    potassium channel, inwardly rectifying subfamily J member 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008427.5 → NP_032453.3  inward rectifier potassium channel 4

      See identical proteins and their annotated locations for NP_032453.3

      Status: VALIDATED

      Source sequence(s)
      AC165278
      Consensus CDS
      CCDS27641.1
      UniProtKB/TrEMBL
      Q8R434, Q8R435
      Related
      ENSMUSP00000094075.4, ENSMUST00000057801.8
      Conserved Domains (2) summary
      pfam01007
      Location:22 → 177
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:184 → 356
      IRK_C; Inward rectifier potassium channel C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      79364427..79396712 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520486.4 → XP_006520549.1  inward rectifier potassium channel 4 isoform X1

      See identical proteins and their annotated locations for XP_006520549.1

      UniProtKB/TrEMBL
      Q8R434, Q8R435
      Conserved Domains (2) summary
      pfam01007
      Location:22 → 177
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:184 → 356
      IRK_C; Inward rectifier potassium channel C-terminal domain

    2. XM_006520488.4 → XP_006520551.1  inward rectifier potassium channel 4 isoform X1

      See identical proteins and their annotated locations for XP_006520551.1

      UniProtKB/TrEMBL
      Q8R434, Q8R435
      Conserved Domains (2) summary
      pfam01007
      Location:22 → 177
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:184 → 356
      IRK_C; Inward rectifier potassium channel C-terminal domain

    3. XM_006520487.5 → XP_006520550.1  inward rectifier potassium channel 4 isoform X1

      See identical proteins and their annotated locations for XP_006520550.1

      UniProtKB/TrEMBL
      Q8R434, Q8R435
      Conserved Domains (2) summary
      pfam01007
      Location:22 → 177
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:184 → 356
      IRK_C; Inward rectifier potassium channel C-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52189.1 GenPept UniProtKB/Swiss-Prot:P52189

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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