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    Kcnd1 potassium voltage-gated channel, Shal-related family, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 16506, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Kcnd1provided by MGI
    Official Full Name
    potassium voltage-gated channel, Shal-related family, member 1provided by MGI
    Primary source
    MGI:MGI:96671
    See related
    Ensembl:ENSMUSG00000009731 AllianceGenome:MGI:96671
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Shal; Kv4.1; Shal1; Kca2-1; mShal1; 1110037K09Rik
    Summary
    This gene encodes a multipass transmembrane protein that comprises a subunit of voltage-gated rapidly inactivating A-type potassium channels. [provided by RefSeq, May 2015]
    Expression
    Broad expression in genital fat pad adult (RPKM 5.4), frontal lobe adult (RPKM 2.2) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    X A1.1; X 3.53 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (7686907..7704517)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (7823759..7838278)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene transcription factor E3 Neighboring gene predicted gene, 39487 Neighboring gene GRIP1 associated protein 1 Neighboring gene microRNA 1198 Neighboring gene STARR-seq mESC enhancer starr_46674 Neighboring gene OTU domain containing 5 Neighboring gene STARR-positive B cell enhancer ABC_E11045 Neighboring gene proviral integration site 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Impaired pattern separation in Tg2576 mice is associated with hyperexcitable dentate gyrus caused by Kv4.1 downregulation. Kim KR, et al. Mol Brain, 2021 Mar 30. PMID 33785038, Free PMC Article
    2. Kv4.1, a Key Ion Channel For Low Frequency Firing of Dentate Granule Cells, Is Crucial for Pattern Separation. Kim KR, et al. J Neurosci, 2020 Mar 11. PMID 32047055, Free PMC Article
    3. Overexpression of tau downregulated the mRNA levels of Kv channels and improved proliferation in N2A cells. Li X, et al. PLoS One, 2015. PMID 25590133, Free PMC Article
    4. Heteropoda toxin 2 interaction with Kv4.3 and Kv4.1 reveals differences in gating modification. DeSimone CV, et al. Mol Pharmacol, 2011 Aug. PMID 21540294
    5. Circadian regulation of a-type potassium currents in the suprachiasmatic nucleus. Itri JN, et al. J Neurophysiol, 2010 Feb. PMID 19939959, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Calbindin regulates Kv4.1 trafficking and excitability in dentate granule cells via CaMKII-dependent phosphorylation.
      Title: Calbindin regulates Kv4.1 trafficking and excitability in dentate granule cells via CaMKII-dependent phosphorylation.
    2. Impaired pattern separation in Tg2576 mice is associated with hyperexcitable dentate gyrus caused by Kv4.1 downregulation.
      Title: Impaired pattern separation in Tg2576 mice is associated with hyperexcitable dentate gyrus caused by Kv4.1 downregulation.
    3. Kv4.1, a Key Ion Channel For Low Frequency Firing of Dentate Granule Cells, Is Crucial for Pattern Separation.
      Title: Kv4.1, a Key Ion Channel For Low Frequency Firing of Dentate Granule Cells, Is Crucial for Pattern Separation.
    4. Expression of the Kv4.1-targeted shRNA significantly decreased interspike intervals and increased repetitive firing rates in suprachiasmatic nucleus (SCN) neurons during the day and at night. results presented here also revealed that the acute knockdown of Kv4.1 had differential effects on the daytime and nighttime input resistance and repetitive firing rates in SCN neurons.
      Title: Acute Knockdown of Kv4.1 Regulates Repetitive Firing Rates and Clock Gene Expression in the Suprachiasmatic Nucleus and Daily Rhythms in Locomotor Behavior.
    5. The complex voltage-dependent gating rearrangements of eukaryotic Kv channels are not limited to the membrane-spanning core but must include the intracellular T1-T1 interface.
      Title: Voltage-dependent gating rearrangements in the intracellular T1-T1 interface of a K+ channel.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables A-type (transient outward) potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    potassium voltage-gated channel subfamily D member 1
    Names
    voltage-gated potassium channel subunit Kv4.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008423.2 → NP_032449.1  potassium voltage-gated channel subfamily D member 1

      See identical proteins and their annotated locations for NP_032449.1

      Status: REVIEWED

      Source sequence(s)
      AK033805, BC139325
      Consensus CDS
      CCDS29974.1
      UniProtKB/Swiss-Prot
      Q03719, Q8CC68
      UniProtKB/TrEMBL
      A2AEX0
      Related
      ENSMUSP00000009875.5, ENSMUST00000009875.5
      Conserved Domains (3) summary
      cl38908
      Location:6 → 143
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam00520
      Location:185 → 417
      Ion_trans; Ion transport protein
      pfam11879
      Location:447 → 550
      DUF3399; Domain of unknown function (DUF3399)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      7686907..7704517
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161827.1 → XP_036017720.1  potassium voltage-gated channel subfamily D member 1 isoform X1

      UniProtKB/Swiss-Prot
      Q03719, Q8CC68
      UniProtKB/TrEMBL
      A2AEX0
      Conserved Domains (3) summary
      cl38908
      Location:6 → 143
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam00520
      Location:185 → 417
      Ion_trans; Ion transport protein
      pfam11879
      Location:447 → 550
      DUF3399; Domain of unknown function (DUF3399)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03719.1 GenPept UniProtKB/Swiss-Prot:Q03719

    Gene LinkOut

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