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    Jrk jerky [ Mus musculus (house mouse) ]

    Gene ID: 16469, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Jrkprovided by MGI
    Official Full Name
    jerkyprovided by MGI
    Primary source
    MGI:MGI:106214
    See related
    Ensembl:ENSMUSG00000046380 AllianceGenome:MGI:106214
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables mRNA binding activity. Predicted to be involved in positive regulation of canonical Wnt signaling pathway. Located in cytoplasm and nucleus. Part of ribonucleoprotein complex. Is expressed in brain; early conceptus; eye; and genitourinary system. Orthologous to human JRK (Jrk helix-turn-helix protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 4.1), ovary adult (RPKM 2.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 D3; 15 34.26 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (74574261..74581171, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (74702412..74709322, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene maestro heat-like repeat family member 4 Neighboring gene STARR-seq mESC enhancer starr_38988 Neighboring gene STARR-seq mESC enhancer starr_38991 Neighboring gene predicted gene, 32994 Neighboring gene activity regulated cytoskeletal-associated protein Neighboring gene STARR-seq mESC enhancer starr_38994 Neighboring gene RIKEN cDNA 4933427E11 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:74553786-74554003 Neighboring gene prostate stem cell antigen Neighboring gene thioesterase superfamily member 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Complex regulation and nuclear localization of JRK protein. Waldron R, et al. Biochem Soc Trans, 2004 Dec. PMID 15506925
    2. The RNA binding domain of Jerky consists of tandemly arranged helix-turn-helix/homeodomain-like motifs and binds specific sets of mRNAs. Liu W, et al. Mol Cell Biol, 2003 Jun. PMID 12773553, Free PMC Article
    3. Mapping and positional cloning of common idiopathic generalized epilepsies: juvenile myoclonus epilepsy and childhood absence epilepsy. Delgado-Escueta AV, et al. Adv Neurol, 1999. PMID 10514826
    4. Sensitivity to jerky gene dosage underlies epileptic seizures in mice. Donovan GP, et al. J Neurosci, 1997 Jun 15. PMID 9169517, Free PMC Article
    5. Jerky, a protein deficient in a mouse epilepsy model, is associated with translationally inactive mRNA in neurons. Liu W, et al. J Neurosci, 2002 Jan 1. PMID 11756500, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. JRK protein associates with a specific chromosomal centromeric locus in the cell cycle G(2) phase.
      Title: Complex regulation and nuclear localization of JRK protein.
    2. Jerky has a role in epilepsy and consists of tandemly arranged helix-turn-helix/homeodomain-like motifs and binds specific sets of mRNAs
      Title: The RNA binding domain of Jerky consists of tandemly arranged helix-turn-helix/homeodomain-like motifs and binds specific sets of mRNAs.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT located_in ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    jerky protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008415.6 → NP_032441.4  jerky protein

      See identical proteins and their annotated locations for NP_032441.4

      Status: VALIDATED

      Source sequence(s)
      AC118022, AK168885
      Consensus CDS
      CCDS27524.1
      UniProtKB/Swiss-Prot
      Q60976
      UniProtKB/TrEMBL
      Q543Z9, Q8C995
      Related
      ENSMUSP00000051842.3, ENSMUST00000050234.4
      Conserved Domains (3) summary
      smart00674
      Location:83 → 147
      CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
      pfam03184
      Location:213 → 382
      DDE_1; DDE superfamily endonuclease
      pfam04218
      Location:14 → 66
      CENP-B_N; CENP-B N-terminal DNA-binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      74574261..74581171 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q60976.2 GenPept UniProtKB/Swiss-Prot:Q60976

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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