Itpr1 inositol 1,4,5-trisphosphate receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Itpr1provided by MGI
Official Full Name: inositol 1,4,5-trisphosphate receptor 1provided by MGI
Primary source: MGI:MGI:96623
See related: Ensembl:ENSMUSG00000030102 AllianceGenome:MGI:96623
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: opt; Ip3r; P400; Pcp1; wblo; IP3R1; Pcp-1; D6Pas2; IP3R 1; InsP3R; Itpr-1; Gm10429; insP3R1
Summary: Enables inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels; phosphatidylinositol binding activity; and protein domain specific binding activity. Involved in several processes, including epithelial fluid transport; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and release of sequestered calcium ion into cytosol. Acts upstream of or within several processes, including calcium ion transport; endoplasmic reticulum calcium ion homeostasis; and voluntary musculoskeletal movement. Located in endoplasmic reticulum; nucleus; and postsynaptic density. Part of calcineurin complex. Is active in Schaffer collateral - CA1 synapse. Is expressed in several structures, including brain; brown fat; genitourinary system; heart; and hemolymphoid system. Human ortholog(s) of this gene implicated in Gillespie syndrome; spinocerebellar ataxia type 15; and spinocerebellar ataxia type 29. Orthologous to human ITPR1 (inositol 1,4,5-trisphosphate receptor type 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cerebellum adult (RPKM 104.2), cortex adult (RPKM 29.7) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 E1- E2; 6 49.74 cM

Exon count:: 65

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (108190044..108528077)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (108213083..108551116)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IP3R-1 aggravates endotoxin-induced acute lung injury in mice by regulating MAM formation and mitochondrial function.
Title: IP3R-1 aggravates endotoxin-induced acute lung injury in mice by regulating MAM formation and mitochondrial function.
IP3R1 underlies diastolic ANO1 activation and pressure-dependent chronotropy in lymphatic collecting vessels.
Title: IP3R1 underlies diastolic ANO1 activation and pressure-dependent chronotropy in lymphatic collecting vessels.
A Gain-of-function Mutation in the Gating Domain of ITPR1 Impairs Motor Movement and Increases Thermal and Mechanical Sensitivity.
Title: A Gain-of-function Mutation in the Gating Domain of ITPR1 Impairs Motor Movement and Increases Thermal and Mechanical Sensitivity.
A gain-of-function mutation in the ITPR1 gating domain causes male infertility in mice.
Title: A gain-of-function mutation in the ITPR1 gating domain causes male infertility in mice.
Binding of the erlin1/2 complex to the third intralumenal loop of IP3R1 triggers its ubiquitin-proteasomal degradation.
Title: Binding of the erlin1/2 complex to the third intralumenal loop of IP(3)R1 triggers its ubiquitin-proteasomal degradation.
IP3 receptor orchestrates maladaptive vascular responses in heart failure.
Title: IP3 receptor orchestrates maladaptive vascular responses in heart failure.
Endophilin A2-mediated alleviation of endoplasmic reticulum stress-induced cardiac injury involves the suppression of ERO1alpha/IP3R signaling pathway.
Title: Endophilin A2-mediated alleviation of endoplasmic reticulum stress-induced cardiac injury involves the suppression of ERO1α/IP(3)R signaling pathway.
IP3R-driven increases in mitochondrial Ca(2+) promote neuronal death in NPC disease.
Title: IP(3)R-driven increases in mitochondrial Ca(2+) promote neuronal death in NPC disease.
Itpr1 regulates the formation of anterior eye segment tissues derived from neural crest cells.
Title: Itpr1 regulates the formation of anterior eye segment tissues derived from neural crest cells.
Inositol 1,4,5-trisphosphate receptor type 3 plays a protective role in hepatocytes during hepatic ischemia-reperfusion injury.
Title: Inositol 1,4,5-trisphosphate receptor type 3 plays a protective role in hepatocytes during hepatic ischemia-reperfusion injury.

Submit: New GeneRIF Correction See all GeneRIFs (123)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (3) 1 citation
Targeted (9) 1 citation
Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Itpr1 (e-PCR), detects polymorphism
- UniSTS:143635

33.MMHAP69FLC6.seq (e-PCR)
- UniSTS:124048

23.MMHAP7FLH2.seq (e-PCR)
- UniSTS:123615

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium channel activity	IEA Inferred from Electronic Annotation more info
enables calcium channel inhibitor activity	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables inositol 1,4,5 trisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels	EXP Inferred from Experiment more info	PubMed
enables inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels	IDA Inferred from Direct Assay more info	PubMed
enables inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels	IMP Inferred from Mutant Phenotype more info	PubMed
enables inositol 1,4,5-trisphosphate-gated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables inositol 1,4,5-trisphosphate-gated calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables inositol 1,4,5-trisphosphate-gated calcium channel activity	IGI Inferred from Genetic Interaction more info	PubMed
enables inositol 1,4,5-trisphosphate-gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables inositol 1,4,5-trisphosphate-gated calcium channel activity	TAS Traceable Author Statement more info	PubMed
enables intracellularly gated calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to cAMP	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endoplasmic reticulum calcium ion homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in epithelial fluid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ion channel modulating, G protein-coupled receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ion channel modulating, G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ligand-gated ion channel signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ligand-gated ion channel signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in liver regeneration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hepatocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in release of sequestered calcium ion into cytosol	IBA Inferred from Biological aspect of Ancestor more info
involved_in release of sequestered calcium ion into cytosol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within voluntary musculoskeletal movement	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in Schaffer collateral - CA1 synapse	EXP Inferred from Experiment more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
part_of calcineurin complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	TAS Traceable Author Statement more info	PubMed
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
is_active_in membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in platelet dense granule membrane	ISO Inferred from Sequence Orthology more info
located_in platelet dense tubular network	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynapse	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IPI Inferred from Physical Interaction more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
is_active_in sarcoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in secretory granule membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in smooth endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IPI Inferred from Physical Interaction more info	PubMed
located_in synaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: inositol 1,4,5-trisphosphate receptor type 1

Names: IP3 receptor; InsP>3<R type I; Purkinje cell protein 1; inositol 1,4,5-trisphosphate-binding protein P400; opisthotonus; protein PCD-6; type 1 InsP3 receptor; type 1 inositol 1,4,5-trisphosphate receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010585.5 → NP_034715.3 inositol 1,4,5-trisphosphate receptor type 1

See identical proteins and their annotated locations for NP_034715.3

Status: VALIDATED

Source sequence(s)

AC156506, AK044776, AK047719, AK049015, AK137477, BU705754, CB521690, CF168791, CF539692, CF744794, CJ236273, CK636937, CN459019, CN692248, DN176734, DV652411, M21530

Consensus CDS

CCDS51869.1

UniProtKB/Swiss-Prot

P11881, P20943, Q99LG5

Related

ENSMUSP00000032192.7, ENSMUST00000032192.9

Conserved Domains (6) summary

smart00472
Location:231 → 287

MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases

pfam00520
Location:2341 → 2600

Ion_trans; Ion transport protein

pfam01365
Location:476 → 665

RYDR_ITPR; RIH domain

pfam02815
Location:232 → 433

MIR; MIR domain

pfam08454
Location:1964 → 2069

RIH_assoc; RyR and IP3R Homology associated

pfam08709
Location:4 → 225

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

108190044..108528077

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006505623.1 → XP_006505686.1 inositol 1,4,5-trisphosphate receptor type 1 isoform X1

Conserved Domains (5) summary

pfam00520
Location:2322 → 2609

Ion_trans; Ion transport protein

pfam01365
Location:474 → 670

RYDR_ITPR; RIH domain

pfam02815
Location:232 → 433

MIR; MIR domain

pfam08454
Location:1973 → 2078

RIH_assoc; RyR and IP3R Homology associated

pfam08709
Location:4 → 225

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
XM_017321407.1 → XP_017176896.1 inositol 1,4,5-trisphosphate receptor type 1 isoform X2

Conserved Domains (5) summary

pfam00520
Location:2321 → 2608

Ion_trans; Ion transport protein

pfam01365
Location:474 → 670

RYDR_ITPR; RIH domain

pfam02815
Location:232 → 433

MIR; MIR domain

pfam08454
Location:1972 → 2077

RIH_assoc; RyR and IP3R Homology associated

pfam08709
Location:4 → 225

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
XM_006505627.1 → XP_006505690.1 inositol 1,4,5-trisphosphate receptor type 1 isoform X6

Conserved Domains (5) summary

pfam00520
Location:2305 → 2592

Ion_trans; Ion transport protein

pfam01365
Location:474 → 670

RYDR_ITPR; RIH domain

pfam02815
Location:232 → 433

MIR; MIR domain

pfam08454
Location:1956 → 2061

RIH_assoc; RyR and IP3R Homology associated

pfam08709
Location:4 → 225

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
XM_006505624.1 → XP_006505687.1 inositol 1,4,5-trisphosphate receptor type 1 isoform X3

Conserved Domains (5) summary

pfam00520
Location:2311 → 2598

Ion_trans; Ion transport protein

pfam01365
Location:474 → 670

RYDR_ITPR; RIH domain

pfam02815
Location:232 → 433

MIR; MIR domain

pfam08454
Location:1962 → 2067

RIH_assoc; RyR and IP3R Homology associated

pfam08709
Location:4 → 225

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
XM_006505625.1 → XP_006505688.1 inositol 1,4,5-trisphosphate receptor type 1 isoform X4

Conserved Domains (5) summary

pfam00520
Location:2310 → 2597

Ion_trans; Ion transport protein

pfam01365
Location:474 → 670

RYDR_ITPR; RIH domain

pfam02815
Location:232 → 433

MIR; MIR domain

pfam08454
Location:1961 → 2066

RIH_assoc; RyR and IP3R Homology associated

pfam08709
Location:4 → 225

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
XM_006505632.1 → XP_006505695.1 inositol 1,4,5-trisphosphate receptor type 1 isoform X11

Conserved Domains (5) summary

pfam00520
Location:2294 → 2581

Ion_trans; Ion transport protein

pfam01365
Location:474 → 670

RYDR_ITPR; RIH domain

pfam02815
Location:232 → 433

MIR; MIR domain

pfam08454
Location:1945 → 2050

RIH_assoc; RyR and IP3R Homology associated

pfam08709
Location:4 → 225

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
XM_006505628.1 → XP_006505691.1 inositol 1,4,5-trisphosphate receptor type 1 isoform X7

Conserved Domains (5) summary

pfam00520
Location:2299 → 2586

Ion_trans; Ion transport protein

pfam01365
Location:474 → 670

RYDR_ITPR; RIH domain

pfam02815
Location:232 → 433

MIR; MIR domain

pfam08454
Location:1950 → 2055

RIH_assoc; RyR and IP3R Homology associated

pfam08709
Location:4 → 225

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
XM_006505629.1 → XP_006505692.1 inositol 1,4,5-trisphosphate receptor type 1 isoform X8

Conserved Domains (5) summary

pfam00520
Location:2298 → 2585

Ion_trans; Ion transport protein

pfam01365
Location:474 → 670

RYDR_ITPR; RIH domain

pfam02815
Location:232 → 433

MIR; MIR domain

pfam08454
Location:1949 → 2054

RIH_assoc; RyR and IP3R Homology associated

pfam08709
Location:4 → 225

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
XM_006505633.1 → XP_006505696.1 inositol 1,4,5-trisphosphate receptor type 1 isoform X12

Conserved Domains (5) summary

pfam00520
Location:2282 → 2569

Ion_trans; Ion transport protein

pfam01365
Location:474 → 670

RYDR_ITPR; RIH domain

pfam02815
Location:232 → 433

MIR; MIR domain

pfam08454
Location:1933 → 2038

RIH_assoc; RyR and IP3R Homology associated

pfam08709
Location:4 → 225

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
XM_017321408.1 → XP_017176897.1 inositol 1,4,5-trisphosphate receptor type 1 isoform X15

UniProtKB/Swiss-Prot

P11881

Related

ENSMUSP00000144880.2, ENSMUST00000203615.3

Conserved Domains (5) summary

pfam00520
Location:2312 → 2599

Ion_trans; Ion transport protein

pfam01365
Location:474 → 670

RYDR_ITPR; RIH domain

pfam02815
Location:232 → 433

MIR; MIR domain

pfam08454
Location:1963 → 2068

RIH_assoc; RyR and IP3R Homology associated

pfam08709
Location:4 → 225

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
XM_006505636.1 → XP_006505699.1 inositol 1,4,5-trisphosphate receptor type 1 isoform X18

UniProtKB/Swiss-Prot

P11881

Conserved Domains (5) summary

pfam00520
Location:2273 → 2560

Ion_trans; Ion transport protein

pfam01365
Location:474 → 670

RYDR_ITPR; RIH domain

pfam02815
Location:232 → 433

MIR; MIR domain

pfam08454
Location:1924 → 2029

RIH_assoc; RyR and IP3R Homology associated

pfam08709
Location:4 → 225

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
XM_006505626.1 → XP_006505689.1 inositol 1,4,5-trisphosphate receptor type 1 isoform X5

Conserved Domains (5) summary

pfam00520
Location:2307 → 2594

Ion_trans; Ion transport protein

pfam01365
Location:459 → 655

RYDR_ITPR; RIH domain

pfam02815
Location:232 → 418

MIR; MIR domain

pfam08454
Location:1958 → 2063

RIH_assoc; RyR and IP3R Homology associated

pfam08709
Location:4 → 225

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
XM_017321409.1 → XP_017176898.1 inositol 1,4,5-trisphosphate receptor type 1 isoform X16

Conserved Domains (5) summary

pfam00520
Location:2306 → 2593

Ion_trans; Ion transport protein

pfam01365
Location:459 → 655

RYDR_ITPR; RIH domain

pfam02815
Location:232 → 418

MIR; MIR domain

pfam08454
Location:1957 → 2062

RIH_assoc; RyR and IP3R Homology associated

pfam08709
Location:4 → 225

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
XM_006505630.1 → XP_006505693.1 inositol 1,4,5-trisphosphate receptor type 1 isoform X9

UniProtKB/Swiss-Prot

P11881

Conserved Domains (5) summary

pfam00520
Location:2298 → 2585

Ion_trans; Ion transport protein

pfam01365
Location:459 → 655

RYDR_ITPR; RIH domain

pfam02815
Location:232 → 418

MIR; MIR domain

pfam08454
Location:1949 → 2054

RIH_assoc; RyR and IP3R Homology associated

pfam08709
Location:4 → 225

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
XM_017321410.1 → XP_017176899.1 inositol 1,4,5-trisphosphate receptor type 1 isoform X17

UniProtKB/Swiss-Prot

P11881

Conserved Domains (5) summary

pfam00520
Location:2297 → 2584

Ion_trans; Ion transport protein

pfam01365
Location:459 → 655

RYDR_ITPR; RIH domain

pfam02815
Location:232 → 418

MIR; MIR domain

pfam08454
Location:1948 → 2053

RIH_assoc; RyR and IP3R Homology associated

pfam08709
Location:4 → 225

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
XM_006505637.1 → XP_006505700.1 inositol 1,4,5-trisphosphate receptor type 1 isoform X19

UniProtKB/Swiss-Prot

P11881

Conserved Domains (5) summary

pfam00520
Location:2258 → 2545

Ion_trans; Ion transport protein

pfam01365
Location:459 → 655

RYDR_ITPR; RIH domain

pfam02815
Location:232 → 418

MIR; MIR domain

pfam08454
Location:1909 → 2014

RIH_assoc; RyR and IP3R Homology associated

pfam08709
Location:4 → 225

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
XM_006505631.3 → XP_006505694.1 inositol 1,4,5-trisphosphate receptor type 1 isoform X10

Conserved Domains (5) summary

pfam00520
Location:2322 → 2609

Ion_trans; Ion transport protein

pfam01365
Location:474 → 670

RYDR_ITPR; RIH domain

pfam02815
Location:232 → 433

MIR; MIR domain

pfam08454
Location:1973 → 2078

RIH_assoc; RyR and IP3R Homology associated

pfam08709
Location:4 → 225

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
XM_036165883.1 → XP_036021776.1 inositol 1,4,5-trisphosphate receptor type 1 isoform X14
XM_030255199.1 → XP_030111059.1 inositol 1,4,5-trisphosphate receptor type 1 isoform X13

Conserved Domains (5) summary

pfam00520
Location:2260 → 2547

Ion_trans; Ion transport protein

pfam01365
Location:412 → 608

RYDR_ITPR; RIH domain

pfam02815
Location:170 → 371

MIR; MIR domain

pfam08454
Location:1911 → 2016

RIH_assoc; RyR and IP3R Homology associated

cl19745
Location:1 → 163

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor