Itgb1bp1 integrin beta 1 binding protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Itgb1bp1provided by MGI
Official Full Name: integrin beta 1 binding protein 1provided by MGI
Primary source: MGI:MGI:1306802
See related: Ensembl:ENSMUSG00000062352 AllianceGenome:MGI:1306802
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Icap1
Summary: Enables protein kinase binding activity. Involved in several processes, including integrin activation; positive regulation of stress fiber assembly; and regulation of cell-substrate adhesion. Located in several cellular components, including cytoskeleton; lamellipodium; and ruffle. Is expressed in left lung and right lung. Orthologous to human ITGB1BP1 (integrin subunit beta 1 binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 30.9), subcutaneous fat pad adult (RPKM 11.0) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 A1.3; 12 8.3 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (21317247..21336285, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (21267246..21286292, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ICAP-1 loss impairs CD8(+) thymocyte development and leads to reduced marginal zone B cells in mice.
Title: ICAP-1 loss impairs CD8(+) thymocyte development and leads to reduced marginal zone B cells in mice.
ICAP-1 monoubiquitylation helps in switching from ROCK2-mediated to MRCKalpha-mediated cell contractility.
Title: ICAP-1 monoubiquitylation coordinates matrix density and rigidity sensing for cell migration through ROCK2-MRCKα balance.
The CCM1 loss resulted in ICAP-1 destabilization, which increased beta1 integrin activation and led to increased RhoA-dependent contractility.
Title: CCM1-ICAP-1 complex controls β1 integrin-dependent endothelial contractility and fibronectin remodeling.
Data show that phosphorylation of ICAP-1alpha by CaMKII controls beta1 integrin activation and cell adhesion.
Title: Calcium and calmodulin-dependent serine/threonine protein kinase type II (CaMKII)-mediated intramolecular opening of integrin cytoplasmic domain-associated protein-1 (ICAP-1α) negatively regulates β1 integrins.
The ICAP-1 works in concert with kindlin-2 to control the dynamics of beta1 integrin-containing fibrillar adhesions and, thereby, regulates fibronectin deposition and osteoblast mineralization.
Title: Osteoblast mineralization requires beta1 integrin/ICAP-1-dependent fibronectin deposition.
Live cell imaging, which was performed in both Icap-1-deficient mouse embryonic fibroblasts and cells expressing active beta(1) integrin, shows that the integrin high affinity state favored by talin is antagonistically controlled by ICAP-1.
Title: Cell adaptive response to extracellular matrix density is controlled by ICAP-1-dependent beta1-integrin affinity.
ICAP-1 regulates beta1 integrin-dependent cell migration by affecting the pattern of focal adhesion formation.
Title: Integrin Cytoplasmic domain-Associated Protein-1 (ICAP-1) promotes migration of myoblasts and affects focal adhesions.
Identify ICAP1 as a novel regulator to prevent excessive sprouting angiogenesis.
Title: Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis.
Integrin cytoplasmic domain-associated protein-1 (ICAP-1) binds ROCK to beta1 integrin at the cell membrane (ICAP-1)
Title: Integrin cytoplasmic domain-associated protein-1 (ICAP-1) interacts with the ROCK-I kinase at the plasma membrane.
ICAP-1 promotes differentiation of osteoprogenitors by supporting their condensation through modulating the integrin high affinity state.
Title: Defective osteoblast function in ICAP-1-deficient mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Targeted (1) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236815

AI449260 (e-PCR)
- UniSTS:180371

AU019480 (e-PCR)
- UniSTS:160189

AJ001373 (e-PCR)
- UniSTS:160190

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GDP-dissociation inhibitor activity	ISO Inferred from Sequence Orthology more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Notch signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in activation of protein kinase B activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within biomineral tissue development	IEA Inferred from Electronic Annotation more info
involved_in blood vessel diameter maintenance	ISO Inferred from Sequence Orthology more info
involved_in blood vessel endothelial cell proliferation involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to fibroblast growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to vascular endothelial growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in integrin activation	IDA Inferred from Direct Assay more info	PubMed
involved_in integrin activation	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in myoblast migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell adhesion involved in substrate-bound cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell migration involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fibroblast migration	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of focal adhesion assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of focal adhesion assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein binding	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein targeting to membrane	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of substrate adhesion-dependent cell spreading	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of substrate adhesion-dependent cell spreading	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of focal adhesion assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein targeting to membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of stress fiber assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in receptor clustering	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell adhesion mediated by integrin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of integrin-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of integrin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tube formation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cell periphery	IBA Inferred from Biological aspect of Ancestor more info
located_in cell periphery	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in lamellipodium	IBA Inferred from Biological aspect of Ancestor more info
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in ruffle	IBA Inferred from Biological aspect of Ancestor more info
located_in ruffle	IDA Inferred from Direct Assay more info	PubMed
located_in ruffle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: integrin beta-1-binding protein 1

Names: bodenin; integrin cytoplasmic domain-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355609.1 → NP_001342538.1 integrin beta-1-binding protein 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AK007635, AK075577, BE947737, BY085309, CX238278

Consensus CDS

CCDS25833.1

UniProtKB/Swiss-Prot

O35671, Q542A8

UniProtKB/TrEMBL

Q3UGH2

Related

ENSMUSP00000134627.2, ENSMUST00000173729.8

Conserved Domains (1) summary

cl17171
Location:1 → 199

PH-like; Pleckstrin homology-like domain
NM_008403.5 → NP_032429.1 integrin beta-1-binding protein 1

See identical proteins and their annotated locations for NP_032429.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AC156032, AK075577, BE947737, BY085309

Consensus CDS

CCDS25833.1

UniProtKB/Swiss-Prot

O35671, Q542A8

UniProtKB/TrEMBL

Q3UGH2

Related

ENSMUSP00000075609.5, ENSMUST00000076260.12

Conserved Domains (1) summary

cl17171
Location:1 → 199

PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

21317247..21336285 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006514989.4 → XP_006515052.1 integrin beta-1-binding protein 1 isoform X1

See identical proteins and their annotated locations for XP_006515052.1

UniProtKB/TrEMBL

Q3UGH2

Conserved Domains (1) summary

cl17171
Location:1 → 177

PH-like; Pleckstrin homology-like domain
XM_006514990.5 → XP_006515053.1 integrin beta-1-binding protein 1 isoform X1

See identical proteins and their annotated locations for XP_006515053.1

UniProtKB/TrEMBL

Q3UGH2

Conserved Domains (1) summary

cl17171
Location:1 → 177

PH-like; Pleckstrin homology-like domain
XM_011243816.4 → XP_011242118.1 integrin beta-1-binding protein 1 isoform X2

UniProtKB/TrEMBL

Q3UGH2

Related

ENSMUSP00000134508.2, ENSMUST00000172834.2

Conserved Domains (1) summary

cl17171
Location:1 → 177

PH-like; Pleckstrin homology-like domain