Itgax integrin alpha X [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Itgaxprovided by MGI
Official Full Name: integrin alpha Xprovided by MGI
Primary source: MGI:MGI:96609
See related: Ensembl:ENSMUSG00000030789 AllianceGenome:MGI:96609
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cr4; N418; Cd11c
Summary: Predicted to enable receptor tyrosine kinase binding activity. Involved in positive regulation of gene expression and positive regulation of myelination. Acts upstream of or within defense response to virus. Located in external side of plasma membrane. Is expressed in heart and hemolymphoid system. Orthologous to human ITGAX (integrin subunit alpha X). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 12.4), lung adult (RPKM 9.2) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F3; 7 69.98 cM

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (127728697..127749829)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (128129526..128150657)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Integrin CD11c regulates B cell homeostasis.
Title: Integrin CD11c regulates B cell homeostasis.
Associations of cortical SPP1 and ITGAX with cognition and common neuropathologies in older adults.
Title: Associations of cortical SPP1 and ITGAX with cognition and common neuropathologies in older adults.
CD11c is not required by microglia to convey neuroprotection after prion infection.
Title: CD11c is not required by microglia to convey neuroprotection after prion infection.
CD103 Regulates Dermal Regulatory T Cell Motility and Interactions with CD11c-Expressing Leukocytes to Control Skin Inflammation.
Title: CD103 Regulates Dermal Regulatory T Cell Motility and Interactions with CD11c-Expressing Leukocytes to Control Skin Inflammation.
CD11c regulates neutrophil maturation.
Title: CD11c regulates neutrophil maturation.
PAX5/ITGAX Contributed to the Progression of Atherosclerosis by Regulation of B Differentiation via TNF-alpha Signaling Pathway.
Title: PAX5/ITGAX Contributed to the Progression of Atherosclerosis by Regulation of B Differentiation via TNF-α Signaling Pathway.
CD11c regulates late-stage T cell development in the thymus.
Title: CD11c regulates late-stage T cell development in the thymus.
Modulation of surface CD11c expression tracks plasticity in murine intestinal tissue eosinophils.
Title: Modulation of surface CD11c expression tracks plasticity in murine intestinal tissue eosinophils.
Definition of a mouse microglial subset that regulates neuronal development and proinflammatory responses in the brain.
Title: Definition of a mouse microglial subset that regulates neuronal development and proinflammatory responses in the brain.
Differential expression of CD11c defines two types of tissue-resident macrophages with different origins in steady-state salivary glands.
Title: Differential expression of CD11c defines two types of tissue-resident macrophages with different origins in steady-state salivary glands.

Submit: New GeneRIF Correction See all GeneRIFs (98)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Chemically induced (ENU) (1)
Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI449405 (e-PCR)
- UniSTS:159697

PMC27130P4 (e-PCR)
- UniSTS:272378

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables receptor tyrosine kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
NOT acts_upstream_of_or_within activated T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial tube morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myelination	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: integrin alpha-X

Names: CD11 antigen-like family member C; CD11C (p150) alpha polypeptide; complement receptor 4; integrin aX; leukocyte adhesion glycoprotein p150,95 alpha chain; leukocyte adhesion receptor p150,95

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001363984.1 → NP_001350913.1 integrin alpha-X isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC124566

UniProtKB/TrEMBL

Q6PG66

Conserved Domains (1) summary

cl00057
Location:151 → 291

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
NM_001363985.1 → NP_001350914.1 integrin alpha-X isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AC124566

Consensus CDS

CCDS90336.1

UniProtKB/TrEMBL

A0A0U1RNJ3, Q8C270

Related

ENSMUSP00000145587.2, ENSMUST00000205460.2

Conserved Domains (1) summary

cl00057
Location:151 → 238

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
NM_021334.3 → NP_067309.1 integrin alpha-X isoform 1 precursor

See identical proteins and their annotated locations for NP_067309.1

Status: VALIDATED

Source sequence(s)

AC124566

Consensus CDS

CCDS40150.1

UniProtKB/Swiss-Prot

Q9QXH4

UniProtKB/TrEMBL

Q3TD13, Q3U1P9

Related

ENSMUSP00000033053.7, ENSMUST00000033053.8

Conserved Domains (4) summary

smart00191
Location:518 → 573

Int_alpha; Integrin alpha (beta-propellor repeats)

cd01469
Location:151 → 326

vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...

pfam00357
Location:1138 → 1152

Integrin_alpha; Integrin alpha cytoplasmic region

pfam08441
Location:616 → 987

Integrin_alpha2; Integrin alpha