Itga4 integrin alpha 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Itga4provided by MGI
Official Full Name: integrin alpha 4provided by MGI
Primary source: MGI:MGI:96603
See related: Ensembl:ENSMUSG00000027009 AllianceGenome:MGI:96603
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CD49D; Itga4B
Summary: Enables fibronectin binding activity. Acts upstream of or within several processes, including chorio-allantoic fusion; face development; and heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Located in cell-cell junction and external side of plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; embryo mesenchyme; genitourinary system; and nervous system. Human ortholog(s) of this gene implicated in autism spectrum disorder and pancreatic cancer. Orthologous to human ITGA4 (integrin subunit alpha 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in liver E14 (RPKM 10.1), liver E14.5 (RPKM 9.6) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 C3; 2 47.38 cM

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (79084767..79163458)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (79255426..79333114)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LRP12 is an endogenous transmembrane inactivator of alpha4 integrins.
Title: LRP12 is an endogenous transmembrane inactivator of α4 integrins.
Distinct bidirectional regulation of LFA1 and alpha4beta7 by Rap1 and integrin adaptors in T cells under shear flow.
Title: Distinct bidirectional regulation of LFA1 and α4β7 by Rap1 and integrin adaptors in T cells under shear flow.
Rexinoids Modulate Effector T Cell Expression of Mucosal Homing Markers CCR9 and alpha4beta7 Integrin and Direct Their Migration In Vitro.
Title: Rexinoids Modulate Effector T Cell Expression of Mucosal Homing Markers CCR9 and α4β7 Integrin and Direct Their Migration In Vitro.
Dual targeting of lymphocyte homing and retention through alpha4beta7 and alphaEbeta7 inhibition in inflammatory bowel disease.
Title: Dual targeting of lymphocyte homing and retention through α4β7 and αEβ7 inhibition in inflammatory bowel disease.
Ablation of VLA4 in multiple myeloma cells redirects tumor spread and prolongs survival.
Title: Ablation of VLA4 in multiple myeloma cells redirects tumor spread and prolongs survival.
VCAM1-alpha4beta1 integrin interaction mediates interstitial tissue reconstruction in 3-D re-aggregate culture of dissociated prepubertal mouse testicular cells.
Title: VCAM1-α4β1 integrin interaction mediates interstitial tissue reconstruction in 3-D re-aggregate culture of dissociated prepubertal mouse testicular cells.
Adaptive Immunity and Pathogenesis of Diabetes: Insights Provided by the alpha4-Integrin Deficient NOD Mouse.
Title: Adaptive Immunity and Pathogenesis of Diabetes: Insights Provided by the α4-Integrin Deficient NOD Mouse.
Integrin alpha4 mediates ATDC5 cell adhesion to negatively charged synthetic polymer hydrogel leading to chondrogenic differentiation.
Title: Integrin α4 mediates ATDC5 cell adhesion to negatively charged synthetic polymer hydrogel leading to chondrogenic differentiation.
The results demonstrate that circulating plasmacytoid dendritic cells are actively recruited into the CNS during acute experimental autoimmune encephalomyelitis through a mechanism largely dependent on CD49d/CD29-integrins.
Title: CD49d/CD29-integrin controls the accumulation of plasmacytoid dendritic cells into the CNS during neuroinflammation.
inhibition of FAK activity may reduce VCAM-1 expression within lymph nodes and thus reduce metastasis of alpha4 integrin-expressing melanoma to lymph nodes.
Title: FAK inhibition reduces metastasis of α4 integrin-expressing melanoma to lymph nodes by targeting lymphatic VCAM-1 expression.

Submit: New GeneRIF Correction See all GeneRIFs (121)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Itga4 (e-PCR), detects polymorphism
- UniSTS:143616

Itga4 (e-PCR), detects polymorphism
- UniSTS:143617

BB284583 (e-PCR)
- UniSTS:207365

Itga4 (e-PCR), detects polymorphism
- UniSTS:507002

D1S3694 (e-PCR)
- UniSTS:474272

BB283915 (e-PCR)
- UniSTS:207328

PMC309677P1 (e-PCR)
- UniSTS:272613

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to C-X3-C chemokine binding	ISO Inferred from Sequence Orthology more info
enables antigen binding	ISO Inferred from Sequence Orthology more info
enables cell adhesion molecule binding	ISO Inferred from Sequence Orthology more info
enables fibronectin binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables fibronectin binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein antigen binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonogenesis involved in innervation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blood vessel remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	TAS Traceable Author Statement more info	PubMed
involved_in cell-cell adhesion in response to extracellular stimulus	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-matrix adhesion	TAS Traceable Author Statement more info	PubMed
involved_in cell-matrix adhesion involved in ameboidal cell migration	ISO Inferred from Sequence Orthology more info
involved_in cellular response to amyloid-beta	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chorio-allantoic fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in clathrin-dependent extracellular exosome endocytosis	ISO Inferred from Sequence Orthology more info
involved_in diapedesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within face development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in import into cell	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within leukocyte cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in leukocyte cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in leukocyte tethering or rolling	ISO Inferred from Sequence Orthology more info
involved_in mesenchyme development	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of protein homodimerization activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
involved_in neuron projection extension	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pericyte cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of T cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of leukocyte cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of leukocyte migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of leukocyte tethering or rolling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vascular associated smooth muscle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in visceral serous pericardium development	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	TAS Traceable Author Statement more info	PubMed
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in growth cone	ISO Inferred from Sequence Orthology more info
part_of integrin alpha4-beta7 complex	ISO Inferred from Sequence Orthology more info
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: integrin alpha-4

Names: CD49 antigen-like family member D; LPAM subunit alpha; VLA-4 receptor, alpha 4 subunit; VLA-4 subunit alpha; integrin alpha-IV; integrin alpha4B; lymphocyte Peyer patch adhesion molecules subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010576.4 → NP_034706.3 integrin alpha-4 precursor

See identical proteins and their annotated locations for NP_034706.3

Status: VALIDATED

Source sequence(s)

AL844590

Consensus CDS

CCDS16168.1

UniProtKB/TrEMBL

Q6NV53, Q792F9

Related

ENSMUSP00000099718.4, ENSMUST00000099972.5

Conserved Domains (2) summary

smart00191
Location:366 → 418

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:463 → 902

Integrin_alpha2; Integrin alpha

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

79084767..79163458

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158647.1 → XP_036014540.1 integrin alpha-4 isoform X1

UniProtKB/TrEMBL

Q8BQ25

Conserved Domains (2) summary

smart00191
Location:366 → 418

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:463 → 565

Integrin_alpha2; Integrin alpha