Irs4 insulin receptor substrate 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Irs4provided by MGI
Official Full Name: insulin receptor substrate 4provided by MGI
Primary source: MGI:MGI:1338009
See related: Ensembl:ENSMUSG00000054667 AllianceGenome:MGI:1338009
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IRS-4
Summary: Predicted to enable insulin receptor binding activity and phosphatidylinositol 3-kinase binding activity. Predicted to be involved in insulin receptor signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be located in membrane. Predicted to be active in cytosol and plasma membrane. Is expressed in several structures, including alimentary system; brain; branchial arch; eye; and genitourinary system. Human ortholog(s) of this gene implicated in congenital nongoitrous hypothyroidism 9. Orthologous to human IRS4 (insulin receptor substrate 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E18 (RPKM 1.0), testis adult (RPKM 0.8) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: X F2; X 62.43 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (140493994..140508213, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (141710998..141725217, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Paraventricular, subparaventricular and periventricular hypothalamic IRS4-expressing neurons are required for normal energy balance.
Title: Paraventricular, subparaventricular and periventricular hypothalamic IRS4-expressing neurons are required for normal energy balance.
our results give the first functional evidence for IRS4 as a critical regulator of BMP/Smad and Akt signalling in the context of muscle differentiation.
Title: IRS4, a novel modulator of BMP/Smad and Akt signalling during early muscle differentiation.
conclude that Y103 is required for the internalization of hCTR1 in response to Cu, that this occurs by a mechanism other than phosphorylation and that mutation of Y103 modulates the interaction with IRS-4
Title: Molecular modulation of the copper and cisplatin transport function of CTR1 and its interaction with IRS-4.
Down-regulation of the insulin receptor substrate 4 (Irs4) gene, may be an important event in the transition from age-related changes to Alzheimer's disease specific-changes.
Title: Clustering of transcriptional profiles identifies changes to insulin signaling as an early event in a mouse model of Alzheimer's disease.
Data demonstrate that IRS4 interacts with the LR. This recruitment is leptin dependent and requires phosphorylation of the Y1077 motif of the LR.
Title: Insulin receptor substrate 4 couples the leptin receptor to multiple signaling pathways.
Protein kinase C-zeta phosphorylates insulin receptor substrate-1, -3, and -4 but not -2.
Title: Protein kinase C-zeta phosphorylates insulin receptor substrate-1, -3, and -4 but not -2: isoform specific determinants of specificity in insulin signaling.
These data indicate that both insulin receptor substrate (IRS)-1 and -3, but not IRS-2 or IRS-4, play key roles in the differentiation of brown adipocytes.
Title: Differential roles of insulin receptor substrates in brown adipocyte differentiation.
These data suggest that IRS-dependent signaling pathways work by recruiting different signaling molecules to determine specificity of IL-2R gamma superfamily cytokines.
Title: Specificity of interleukin-2 receptor gamma chain superfamily cytokines is mediated by insulin receptor substrate-dependent pathway.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1) 1 citation
Targeted (3) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Irs4 (e-PCR), detects polymorphism
- UniSTS:526086

PMC86565P3 (e-PCR)
- UniSTS:273536

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables insulin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol 3-kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in insulin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: insulin receptor substrate 4

Names: phosphoprotein of 160 kDa; pp160

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010572.2 → NP_034702.2 insulin receptor substrate 4

See identical proteins and their annotated locations for NP_034702.2

Status: VALIDATED

Source sequence(s)

AK045172, BC060235

Consensus CDS

CCDS30445.1

UniProtKB/Swiss-Prot

A2BHF6, Q8BRB9, Q9Z0Y7

UniProtKB/TrEMBL

B9EK93

Related

ENSMUSP00000067085.8, ENSMUST00000067841.8

Conserved Domains (2) summary

cd01204
Location:232 → 335

PTB_IRS; Insulin receptor substrate phosphotyrosine-binding domain (PTBi)

cd01257
Location:78 → 203

PH_IRS; Insulin receptor substrate (IRS) pleckstrin homology (PH) domain